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Models of Seizures and Epilepsy: Important Tools in the Discovery and Evaluation of Novel Epilepsy Therapies
Models of seizures and epilepsy continue to play an important role in the early discovery of new therapies for the symptomatic treatment of epilepsy....
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Critical NIH Resources to Advance Therapies for Pain: Preclinical Screening Program and Phase II Human Clinical Trial Network
Opioid-related death and overdose have now reached epidemic proportions. In response to this public health crisis, the National Institutes of Health...
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Protocol for 6 Hz Corneal Stimulation in Rodents for Refractory Seizures
The 6-hertz (6 Hz) model is an effective tool to screen drugs for psychomotor seizures and/or treatment-resistant focal seizures. It is known to...
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The National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP)
For over 40 years, the National Institute of Neurological Disorders and Stroke/National Institutes of Health-funded Anticonvulsant Screening Program...
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Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP)
Cannabidiol (CBD) is a cannabinoid component of marijuana that has no significant activity at cannabinoid receptors or psychoactive effects. There is...
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Procedures for Electrical and Chemical Kindling Models in Rats and Mice
Since the first description of the kindling phenomenon, kindling paradigms have become frequently used chronic models in epilepsy research. The...
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Anticonvulsant Effectiveness and Neurotoxicity Profile of 4-butyl-5-[(4-chloro-2-methylphenoxy)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) in Mice
Protective (antiseizure) effects of 4-butyl-5-[(4-chloro-2-methylphenoxy)-methyl]-2,4-dihydro-3 H -1,2,4-triazole-3-thione (TPL-16) and acute...
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Antiepileptic Drugs in Pediatrics
Epilepsy affects approximately 1% of the population. First-line treatment for epilepsy is the administration of anti-seizure medication, also...
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Validation of a Preclinical Drug Screening Platform for Pharmacoresistant Epilepsy
The successful identification of promising investigational therapies for the treatment of epilepsy can be credited to the use of numerous animal...
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Synthesis, anticonvulsant activity, and molecular modeling studies of novel 1-phenyl/1-(4-chlorophenyl)-2-(1H-triazol-1-yl)ethanol ester derivatives
A series of new ester derivatives were synthesized by the reaction of various acids with 1-phenyl/1-(4-chlorophenyl)-2-(1 H -triazol-1-yl)ethanol and...
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Animal Models of Seizures and Epilepsy: Past, Present, and Future Role for the Discovery of Antiseizure Drugs
The identification of potential therapeutic agents for the treatment of epilepsy requires the use of seizure models. Except for some early...
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Strengthening the Case for Epilepsy Drug Development: Bridging Experiences from the Alzheimer’s Disease Field—An Opinion
Given the sheer number of drugs (over 20!) available for treatment of seizures, epilepsy can be considered one of the most successful areas in...
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The Search for New Screening Models of Pharmacoresistant Epilepsy: Is Induction of Acute Seizures in Epileptic Rodents a Suitable Approach?
Epilepsy, a prevalent neurological disease characterized by spontaneous recurrent seizures (SRS), is often refractory to treatment with anti-seizure...
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Evaluation of the Anticonvulsant Effect of Brilliant Blue G, a Selective P2X7 Receptor Antagonist, in the iv PTZ-, Maximal Electroshock-, and 6 Hz-Induced Seizure Tests in Mice
Epilepsy is one of the most common neurological disorders which is diagnosed in around 65 million people worldwide. Clinically available...
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Preclinical Comparison of Mechanistically Different Antiseizure, Antinociceptive, and/or Antidepressant Drugs in a Battery of Rodent Models of Nociceptive and Neuropathic Pain
The series of experiments herein evaluated prototype drugs representing different mechanisms of antiseizure, antinociceptive or antidepressant action...
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Design and Comparative Evaluation of the Anticonvulsant Profile, Carbonic-Anhydrate Inhibition and Teratogenicity of Novel Carbamate Derivatives of Branched Aliphatic Carboxylic Acids with 4-Aminobenzensulfonamide
Epilepsy is one of the most common neurological diseases, with between 34 and 76 per 100,000 people develo** epilepsy annually. Epilepsy therapy...
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In vitro and in silico evaluation of chromene based aroyl hydrazones as anticonvulsant agents
Series of aroyl hydrazones of 2 H -chromene and coumarin carbaldehydes were synthesized and evaluated for their anticonvulsant activity and...
