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The Administration of Cadmium for 2, 3 and 4 Months Causes a Loss of Recognition Memory, Promotes Neuronal Hypotrophy and Apoptosis in the Hippocampus of Rats
Cadmium (Cd) is a toxic metal and classified as a carcinogen whose exposure could affect the function of the central nervous system. There are...
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Glial Cell Line-Derived Neurotrophic Factor and Focal Ischemic Stroke
Focal ischemic stroke (FIS) is a leading cause of human debilitation and death. Following the onset of a FIS, the brain experiences a series of...
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Metforminium Decavanadate (MetfDeca) Treatment Ameliorates Hippocampal Neurodegeneration and Recognition Memory in a Metabolic Syndrome Model
The consumption of foods rich in carbohydrates, saturated fat, and sodium, accompanied by a sedentary routine, are factors that contribute to the...
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The Tumor Microenvironment in Hepatocellular Carcinoma
The tumor microenvironment refers to the noncancerous tissue surrounding cancer cells. The tumor microenvironment consists of stromal cells and...
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Expression of a Secretable, Cell-Penetrating CDKL5 Protein Enhances the Efficacy of Gene Therapy for CDKL5 Deficiency Disorder
Although delivery of a wild-type copy of the mutated gene to cells represents the most effective approach for a monogenic disease, proof-of-concept...
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Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathology
BackgroundDeposition of amyloid β, which is produced by amyloidogenic cleavage of APP by β- and γ-secretase, is one of the primary hallmarks of AD...
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The Neurotrophic, Neuroprotective, Mitogenic, Antioxidant, and Antiapoptotic Properties of Vasopressin
The vasopressinergic system is involved in the regulation of numerous physiological functions. This review focuses on the less well studied roles of...
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Analysis of mRNA Dynamics Using RNA Sequencing Data
The RNA abundance of each gene is determined by its rates of transcription and RNA decay. Biochemical experiments that measure these rates, including...
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Myosin XVI
Myosin XVI (Myo16), a vertebrate-specific motor protein, is a recently discovered member of the myosin superfamily. The detailed functionality...
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The Role of Oxidative Stress in Trisomy 21 Phenotype
Extensive research has been conducted to gain a deeper understanding of the deregulated metabolic pathways in the development of trisomy 21 (T21) or...
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Multifunctional Liposomes Modulate Purinergic Receptor-Induced Calcium Wave in Cerebral Microvascular Endothelial Cells and Astrocytes: New Insights for Alzheimer’s disease
In light of previous results, we assessed whether liposomes functionalized with ApoE-derived peptide (mApoE) and phosphatidic acid (PA)...
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Host/microbiota interactions in health and diseases—Time for mucosal microbiology!
During the last 20 years, a new field of research delineating the importance of the microbiota in health and diseases has emerged. Inappropriate...
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Astroglia Abnormalities in Post-stroke Mood Disorders
Stroke is the leading cause of human death and disability. After a stroke, many patients may have some physical disability, including difficulties in...
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Protective Effects of Spermidine and Melatonin on Deltamethrin-Induced Cardiotoxicity and Neurotoxicity in Zebrafish
Increased application of the pyrethroid insecticide deltamethrin has adverse effects on the cardiac system and neurobehavior on the non-target...
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Mitochondrial Disorders
Mitochondria, double-membrane organelles, are the major site of energy production and vital components of all eukaryotic cells because of the...
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Diagnostic Approach to Cerebellar Hypoplasia
Cerebellar hypoplasia (CH) refers to a cerebellum of reduced volume with preserved shape. CH is associated with a broad heterogeneity in...
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The Effects of Non-selective Dopamine Receptor Activation by Apomorphine in the Mouse Hippocampus
Apomorphine is a dopamine receptor agonist that activates D 1 –D 5 dopamine receptors and that is used to treat Parkinson’s disease (PD). However, the...
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Gut Microbiota Composition and Epigenetic Molecular Changes Connected to the Pathogenesis of Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder, and its pathogenesis is not fully known. Although there are several hypotheses, such as...
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Causes of Congenital Malformations
Congenital malformations are structural abnormalities due to faulty development, present at birth, and amongst the major causes of prenatal,...
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A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation
BackgroundInteractions between neurons, astrocytes, and microglia critically influence neuroinflammatory responses to insult in the central nervous...
