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Astroglia Abnormalities in Post-stroke Mood Disorders

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Astrocytes in Psychiatric Disorders

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 26))

Abstract

Stroke is the leading cause of human death and disability. After a stroke, many patients may have some physical disability, including difficulties in moving, speaking, and seeing, but patients may also exhibit changes in mood manifested by depression, anxiety, and cognitive changes which we call post-stroke mood disorders (PSMDs). Astrocytes are the most diverse and numerous glial cell type in the central nervous system (CNS). They provide structural, nutritional, and metabolic support to neurons and regulate synaptic activity under normal conditions. Astrocytes are also critically involved in focal ischemic stroke (FIS). They undergo many changes after FIS. These changes may affect acute neuronal death and brain damage as well as brain recovery and PSMD in the chronic phase after FIS. Studies using postmortem brain specimens and animal models of FIS suggest that astrocytes/reactive astrocytes are involved in PSMD. This chapter provides an overview of recent advances in the molecular base of astrocyte in PSMD. As astrocytes exhibit high plasticity after FIS, we suggest that targeting local astrocytes may be a promising strategy for PSMD therapy.

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Acknowledgments

This work was supported by the National Institutes of Health [National Institute of Neurological Disorders and Stroke (NINDS) grants R01NS069726 and R01NS094539 to SD] and the America Heart Association [Midwest Affiliate Grant-in-Aid (16GRNT31280014) and NCRG-IRG 16IRG27780023 to SD].

Author Contributions

Tracey Singer, original draft preparation and editing; Sarah Ding, original draft preparation; Shinghua Ding, original draft preparation, editing, and supervision.

Conflict of Interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Dalton Cardiovascular Research Center, Columbia, MO, USA

    Tracey Singer, Sarah Ding & Shinghua Ding

  2. Department of Biomedical, Biological and Chemical Engineering, University of Missouri, Columbia, MO, USA

    Shinghua Ding

Authors
  1. Tracey Singer
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  2. Sarah Ding
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  3. Shinghua Ding
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Corresponding author

Correspondence to Shinghua Ding .

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Editors and Affiliations

  1. Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China

    Baoman Li

  2. Department of Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, USA

    Vladimir Parpura

  3. Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

    Alexei Verkhratsky

  4. Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Rome, Italy

    Caterina Scuderi

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Singer, T., Ding, S., Ding, S. (2021). Astroglia Abnormalities in Post-stroke Mood Disorders. In: Li, B., Parpura, V., Verkhratsky, A., Scuderi, C. (eds) Astrocytes in Psychiatric Disorders. Advances in Neurobiology, vol 26. Springer, Cham. https://doi.org/10.1007/978-3-030-77375-5_6

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