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Dual role of ANGPTL4 in inflammation
Background:Angiopoietin-like 4 (ANGPTL4) belongs to the angiopoietin-like protein family and mediates the inhibition of lipoprotein lipase activity....
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The ANGPTL4-HIF-1α loop: a critical regulator of renal interstitial fibrosis
BackgroundRenal interstitial fibrosis (RIF) is a progressive, irreversible terminal kidney disease with a poor prognosis and high mortality....
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ANGPTL4 regulates ovarian cancer progression by activating the ERK1/2 pathway
BackgroundOvarian cancer (OC) has the highest mortality rate among all gynecological malignancies. A hypoxic microenvironment is a common feature of...
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ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation
Atherosclerosis, the leading cause of death, is a vascular disease of chronic inflammation. We recently showed that angiopoietin-like 4 (ANGPTL4)...
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ANGPTL4 accelerates ovarian serous cystadenocarcinoma carcinogenesis and angiogenesis in the tumor microenvironment by activating the JAK2/STAT3 pathway and interacting with ESM1
BackgroundOvarian cancer (OC) is a malignant neoplasm that displays increased vascularization. Angiopoietin-like 4 (ANGPTL4) is a secreted...
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Transcriptomic and functional analysis of ANGPTL4 overexpression in pancreatic cancer nominates targets that reverse chemoresistance
BackgroundPancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers based on five-year survival rates. Genes contributing to...
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Cross-talk between ANGPTL4 gene SNP Rs1044250 and weight management is a risk factor of metabolic syndrome
BackgroundThe prevalence of metabolic syndrome (Mets) is closely related to an increased incidence of cardiovascular events. Angiopoietin-like...
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ANGPTL4 overexpression inhibits tumor cell adhesion and migration and predicts favorable prognosis of triple-negative breast cancer
BackgroundTriple-negative breast cancer (TNBC) patients have relatively poor clinical outcomes. A marker predicting the prognosis of patients with...
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Exosomal protein angiopoietin-like 4 mediated radioresistance of lung cancer by inhibiting ferroptosis under hypoxic microenvironment
BackgroundHypoxia-mediated radioresistance is a major reason for the adverse radiotherapy outcome of non-small cell lung cancer (NSCLC) in clinical,...
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Angiopoietin-Like Protein 4 Is Involved in Manganese Superoxide Dismutase-Mediated Suppression of Breast Cancer Cell Growth
This study aims to understand the molecular basis of manganese superoxide dismutase (MnSOD) impacts on breast cancer cell growth. Modulation of the...
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Metabolic classifications of renal cell carcinoma reveal intrinsic connections with clinical and immune characteristics
BackgroundKidney cancer undergoes a dramatic metabolic shift and has demonstrated responsiveness to immunotherapeutic intervention. However,...
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The potential crosstalk between tumor and plasma cells and its association with clinical outcome and immunotherapy response in bladder cancer
BackgroundAlthough immunotherapy is effective in improving the clinical outcomes of patients with bladder cancer (BC), it is only effective in a...
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Deregulation of angiopoietin-like 4 slows ovarian cancer progression through vascular endothelial growth factor receptor 2 phosphorylation
BackgroundAs a tissue-specific proangiogenic or antiangiogenic agent, angiopoietin-like 4 (ANGPTL4) has recently gained attention in many diseases,...
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Determination of in vitro hepatotoxic potencies of a series of perfluoroalkyl substances (PFASs) based on gene expression changes in HepaRG liver cells
Per- and polyfluoroalkyl substances (PFASs) are omnipresent and have been shown to induce a wide range of adverse health effects, including...
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PRSS21/testisin inhibits ovarian tumor metastasis and antagonizes proangiogenic angiopoietins ANG2 and ANGPTL4
AbstractOvarian cancer is the leading cause of death among all the gynecological cancers in the USA. Ovarian cancer employs a unique mode of...
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Human adaptation to high altitude: a review of convergence between genomic and proteomic signatures
Both genomics- and proteomics-based investigations have identified several essential genes, proteins, and pathways that may facilitate human adaptive...
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Biological Markers of Insulin Sensitivity Links with Dietary Antioxidant
Obesity plays an essential role in develo** chronic conditions such as metabolic syndrome (MetS), nonalcoholic fatty liver disease (NAFLD), and...
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Menstrual blood-derived stromal cells: insights into their secretome in acute hypoxia conditions
BackgroundDespite constant advances in regenerative medicine, the closure of chronic wounds is still challenging. Therapeutic approaches using...
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Transcriptional Profiles Reveal Deregulation of Lipid Metabolism and Inflammatory Pathways in Neurons Exposed to Palmitic Acid
The effects of the consumption of high-fat diets (HFD) have been studied to unravel the molecular pathways they are altering in order to understand...
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Identification and validation of a novel glycolysis-related gene signature for predicting the prognosis in ovarian cancer
BackgroundOvarian cancer (OC) is the most lethal gynaecological tumor. Changes in glycolysis have been proven to play an important role in OC...
