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Gut microbiota-host lipid crosstalk in Alzheimer’s disease: implications for disease progression and therapeutics
Trillions of intestinal bacteria in the human body undergo dynamic transformations in response to physiological and pathological changes. Alterations...
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Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B
Cathepsin B is a cysteine protease that is implicated in multiple aspects of Alzheimer’s disease pathogenesis. The endogenous inhibitor of this...
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Understanding Glycogen Synthase Kinase-3: A Novel Avenue for Alzheimer’s Disease
Alzheimer’s Disease (AD) is the most prevalent form of age-related dementia. Even though a century has passed since the discovery of AD, the exact...
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Impaired 24-h activity patterns are associated with an increased risk of Alzheimer’s disease, Parkinson’s disease, and cognitive decline
BackgroundSleep-wake regulating circuits are affected during prodromal stages in the pathological progression of both Alzheimer’s disease (AD) and...
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Alzheimer’s Disease-Related Epigenetic Changes: Novel Therapeutic Targets
Aging is a significant risk factor for Alzheimer’s disease (AD), although the precise mechanism and molecular basis of AD are not yet fully...
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Investigation of the Circular Transcriptome in Alzheimer’s Disease Brain
Circular RNAs (circRNAs) are a subclass of non-coding RNAs which have demonstrated potential as biomarkers for Alzheimer’s disease (AD). In this...
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Human Embryonic Stem Cells as a Therapy for Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive decline in neurocognitive performance with symptoms such as...
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Alteration of medial temporal lobe metabolism related to Alzheimer’s disease and dementia with lewy bodies
BackgroundAssociation of medial temporal lobe (MTL) metabolism with Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) has not been...
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Antioxidants: an approach for restricting oxidative stress induced neurodegeneration in Alzheimer’s disease
Alzheimer’s disease (AD) is the leading cause of dementia, affecting millions of people worldwide . Oxidative stress contributes towards induction of...
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Ferroptosis in the Pathogenesis of Alzheimer’s Disease: The New Evidence for Validation of FAB Model
AbstractAlzheimer’s disease is an age-associated progressive disorder, characterized by neurodegeneration and following cognitive decline. Several...
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Blood-Based Biomarkers for Early Alzheimer’s Disease Diagnosis in Real-World Settings
As our knowledge about the biology of Alzheimer’s disease (AD) expands and we recognize the significance of early intervention for effective...
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Limitations of the human iPSC-derived neuron model for early-onset Alzheimer’s disease
Non-familial Alzheimer’s disease (AD) occurring before 65 years of age is commonly referred to as early-onset Alzheimer’s disease (EOAD) and...
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From Lab Bench to Hope: Emerging Gene Therapies in Clinical Trials for Alzheimer’s Disease
Alzheimer’s disease is a progressive neurodegenerative disorder that affects memory and cognitive abilities, affecting millions of people around the...
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Non-invasive Biomarkers for Early Detection of Alzheimer’s Disease: a New-Age Perspective
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that primarily affects the elderly population. It gradually leads to memory...
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Integrating a multimodal lifestyle intervention with medical food in prodromal Alzheimer’s disease: the MIND-ADmini randomized controlled trial
BackgroundThe Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits from a...
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Calcium Channels as a Potential Therapeutic Target for Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common type of dementia that characterizes the accumulation of amyloid-β plaques and neurofibrillary tangles in...
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Dietary Components as Promoters of Medicinal Activity in Alzheimer’s Disease
Alzheimer’s disease (AD) is among the most serious neurodegenerative diseases with poor diagnosis and treatment. AD is one of the most common types...
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Analysis of Resting-State Functional Magnetic Resonance Imaging in Alzheimer’s Disease
Alzheimer’s disease (AD) has been characterized by widespread network disconnection among brain regions, widely overlap** with the hallmarks of the...
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Liquid–liquid phase separation in Alzheimer’s disease
The pathological aggregation and misfolding of tau and amyloid-β play a key role in Alzheimer’s disease (AD). However, the underlying pathological...
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The Therapeutic Potential of Focused Ultrasound in Patients with Alzheimer’s Disease
Alzheimer’s disease (AD) is a common progressive neurodegenerative disease characterized by abnormal deposition of β-amyloid (Aβ) and...