Abstract
Alzheimer’s disease (AD) is among the most serious neurodegenerative diseases with poor diagnosis and treatment. AD is one of the most common types of dementia mostly in geriatric population and has been defined as “a public health crisis,” according to Alzheimer’s disease association. Currently, only a few drugs have been approved for clinical use including donepezil, rivastigmine, galantamine, and memantine. Unfortunately, medication regimens to date attenuate symptomatology and despite the improvement in drug discovery and drug development field, there is no existing cure. Computer-aided drug design (CADD) methods are especially important for determining AD-modifying therapeutic targets. The applications of CADD in pharmaceutical community allow clinical pharmacists, medicinal chemists, and other researches to predict the binding affinity between ligands and targets and to understand in-depth these interactions. Molecular docking and other alternative computer-aided drug design methods show that several dietary phytochemicals found mainly in fruits, vegetables, plants, and spices could meet the criteria of novel AD disease-modifying agents. Molecular dynamic simulations and in silico docking studies showed a superior potential of several dietary phytochemicals (caffeine, curcumin, crocus sativus, quercetin, resveratrol, oleuropein, ellagic acid, epigallocatechin-3 gallate, luteolin, astaxanthin, and morin) to act as drug-likeness inhibitors and as promoters of available medication for AD.
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Kalli, E.G. (2023). Dietary Components as Promoters of Medicinal Activity in Alzheimer’s Disease. In: Vlamos, P., Kotsireas, I.S., Tarnanas, I. (eds) Handbook of Computational Neurodegeneration. Springer, Cham. https://doi.org/10.1007/978-3-319-75922-7_39
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DOI: https://doi.org/10.1007/978-3-319-75922-7_39
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