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Human Embryonic Stem Cells as a Therapy for Alzheimer’s Disease

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Handbook of Animal Models and its Uses in Cancer Research

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Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive decline in neurocognitive performance with symptoms such as neuroinflammation, decreased hippocampus volume, learning and memory issues, as well as problems with visuospatial functions. The mechanisms involved in the pathogenesis of AD include aggregation of the amyloid precursor protein, activation of cholinesterases, formation of senile plaques, hyperphosphorylation of tau protein, and activation of microglia. Several therapeutic strategies have been adopted toward the management of AD, especially stem cell technology. This chapter describes human embryonic stem cells as a viable therapy for the management of AD.

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Authors and Affiliations

  1. Department of Biochemistry, Federal University of Technology, Akure, Akure, Nigeria

    Stephen Adeniyi Adefegha

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  1. Stephen Adeniyi Adefegha
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Correspondence to Stephen Adeniyi Adefegha .

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  1. Cancer Biology and Biotechnology Lab Faculty of Allied Health Sciences Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai, India

    Surajit Pathak

  2. Cancer Biology and Biotechnology Lab Faculty of Allied Health Sciences Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai, India

    Antara Banerjee

  3. AGENTEM (Adana Genetic Diseases Diagnosis and Treatment Center) & Medical Genetics Department of Medical Faculty, Cukurova University, Adana, Turkey

    Atil Bisgin

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Adefegha, S.A. (2023). Human Embryonic Stem Cells as a Therapy for Alzheimer’s Disease. In: Pathak, S., Banerjee, A., Bisgin, A. (eds) Handbook of Animal Models and its Uses in Cancer Research. Springer, Singapore. https://doi.org/10.1007/978-981-19-3824-5_40

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