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Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations
Background:Male breast cancer (MBC) is still poorly understood with a large proportion arising in families with a history of breast cancer. Genomic...
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Germline TP53 mutational spectrum in French Canadians with breast cancer
BackgroundSpecific germline mutations in the hereditary breast-ovarian cancer susceptibility (HBC/HBOC) genes, BRCA1, BRCA2 and PALB2, have been...
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TP53 Arg 72Pro and MDM2 SNP309 Polymorphisms and Colorectal Cancer Risk: A West Algerian Population Study
The tumor suppressor gene TP53 and its regulator MDM2 are both key players involved in multiple pathways including apoptosis, cellular...
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Prognostic value of ERCC1, ERCC2, XRCC1, and TP53 single nucleotide polymorphisms in patients with early-stage non-small cell lung cancer
Identification of biomarkers used for the prognostic evaluation of non-small cell lung cancer (NSCLC) patients is important. The aim of this study...
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The association between polymorphism of P53 Codon72 Arg/Pro and hepatocellular carcinoma susceptibility: evidence from a meta-analysis of 15 studies with 3,704 cases
Emerging evidence has shown that p53 gene participates in human carcinogenesis as tumor suppressors. Polymorphism of p53 gene codon72 arginine...
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Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling
BackgroundMonolayer cultures of immortalised cell lines are a popular screening tool for novel anti-cancer therapeutics, but these methods can be a...
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Association between the TP53 codon 72 polymorphism and risk of oral squamous cell carcinoma in Asians: a meta-analysis
BackgroundSeveral epidemiological studies have previously investigated the association between the TP53 codon 72 polymorphism and oral squamous cell...
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Association of P53 (−16ins-Pro) Haplotype with the Decreased Risk of Differentiated Thyroid Carcinoma in Iranian-Azeri Patients
Association of P53 polymorphisms with the increased risk of various cancers has been investigated in numerous studies. However, the results were...
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In vitro biosafety profile evaluation of multipotent mesenchymal stem cells derived from the bone marrow of sarcoma patients
BackgroundIn osteosarcoma (OS) and most Ewing sarcoma (EWS) patients, the primary tumor originates in the bone. Although tumor resection surgery is...
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Genetic polymorphisms and gene-dosage effect in ovarian cancer risk and response to paclitaxel/cisplatin chemotherapy
BackgroundOvarian malignancies are often diagnosed in advanced stage and at the same time resistance to treatment, both intrinsic and developed...
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Genetic variability in drug transport, metabolism or DNA repair affecting toxicity of chemotherapy in ovarian cancer
BackgroundThis study aimed to determine whether single nucleotide polymorphisms (SNPs) in genes involved in DNA repair or metabolism of taxanes or...
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Lung cancer risk and genetic variants in East Asians: a meta-analysis
Inconsistent results are often found regarding the risk of genetic variants in lung cancer association studies. To alleviate these conflicts, we...
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Apoptosis for prediction of radiotherapy late toxicity: lymphocyte subset sensitivity and potential effect of TP53 Arg72Pro polymorphism
We tested apoptosis levels in in vitro irradiated T-lymphocytes from breast cancer (BC) patients with radiotherapy-induced late effects. Previous...
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A pilot study evaluating genetic alterations that drive tobacco- and betel quid-associated oral cancer in Northeast India
The susceptibility of an individual to oral cancer is mediated by genetic factors and carcinogen-exposure behaviors such as betel quid chewing,...
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Lung Cancer: Diagnosis and Treatment Approach
Lung cancer is one of the most common causes of cancer death in the world. There are many risk factors for lung cancer including tobacco smoking,...
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Association between TP53 Arg72Pro polymorphism and thyroid carcinoma risk
TP53 Arg72Pro polymorphism has been proposed to have some effects on host’s susceptibility to cancer. Several studies were published to assess the...
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Association of TP53 codon 72 and intron 3 16-bp Ins/Del polymorphisms with cervical cancer risk
Cervical cancer incidence has grown worldwide, with it being a more significant problem in develo** countries. Invasive squamous cell cervical...