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Improving cardiotoxicity prediction in cancer treatment: integration of conventional circulating biomarkers and novel exploratory tools
Early detection strategies and improvements in cancer treatment have dramatically reduced the cancer mortality rate in the United States (US)....
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Vessel co-option in glioblastoma: emerging insights and opportunities
Vessel co-option is the movement of cancer cells towards and along the pre-existing vasculature and is an alternative to angiogenesis to gain access...
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A Mutual Nexus Between Epilepsy and α-Synuclein: A Puzzle Pathway
Alpha-synuclein (α-Syn) is a specific neuronal protein that regulates neurotransmitter release and trafficking of synaptic vesicles....
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Complexity of skeletal muscle degeneration: multi-systems pathophysiology and organ crosstalk in dystrophinopathy
Duchenne muscular dystrophy is a highly progressive muscle wasting disorder due to primary abnormalities in one of the largest genes in the human...
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Identification of core genes and pathways between geriatric multimorbidity and renal insufficiency: potential therapeutic agents discovered using bioinformatics analysis
BackgroundGeriatric people are prone to suffer from multiple chronic diseases, which can directly or indirectly affect renal function. Through...
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Transcription factors: key regulatory targets of vascular smooth muscle cell in atherosclerosis
Atherosclerosis (AS), leading to gradual occlusion of the arterial lumen, refers to the accumulation of lipids and inflammatory debris in the...
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APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease
BackgroundAggregation of amyloid β into plaques in the brain is one of the earliest pathological events in Alzheimer’s disease (AD). The exact...
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Remodeling of Adipose Tissues by Fatty Acids: Mechanistic Update on Browning and Thermogenesis by n-3 Polyunsaturated Fatty Acids
Enhancing thermogenesis by increasing the amount and activity of brown and brite adipocytes is a potential therapeutic target for obesity and its...
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Network analysis of atherosclerotic genes elucidates druggable targets
BackgroundAtherosclerosis is one of the major causes of cardiovascular disease. It is characterized by the accumulation of atherosclerotic plaque in...
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Epigenetic modulation of ferroptosis in cancer: Identifying epigenetic targets for novel anticancer therapy
Ferroptosis is a newly recognized form of oxidative-regulated cell death resulting from iron-mediated lipid peroxidation accumulation....
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Metabolic regulation of microglial phagocytosis: Implications for Alzheimer's disease therapeutics
Microglia, the resident immune cells of the brain, are increasingly implicated in the regulation of brain health and disease. Microglia perform...
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Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes
BackgroundThyroid hormone responsive protein (THRSP) is a lipogenic nuclear protein that is highly expressed in murine adipose tissue, but its role...
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microRNAs signatures as potential biomarkers of structural cardiotoxicity in human-induced pluripotent stem-cell derived cardiomyocytes
Identification of early biomarkers of heart injury and drug-induced cardiotoxicity is important to eliminate harmful drug candidates early in...
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Function of lipid binding proteins of parasitic helminths: still a long road
Infections with parasitic helminths cause severe debilitating and sometimes lethal diseases in humans and domestic animals on a global scale. Unable...
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Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function
Clinically, cardiac dysfunction is a key component of sepsis-induced multi-organ failure. Mitochondria are essential for cardiomyocyte homeostasis,...
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METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice
Physical activity has many beneficial effects on metabolic disorders, such as obesity, insulin resistance, and diabetes. Meteorin-like protein...
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Mechanism of continuous high temperature affecting growth performance, meat quality, and muscle biochemical properties of finishing pigs
BackgroundThe mechanism of high ambient temperature affecting meat quality is not clear till now. This study investigated the effect of high ambient...
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Lipid metabolism reprogramming in renal cell carcinoma
Metabolic reprogramming is recognized as a hallmark of cancer. Lipids are the essential biomolecules required for membrane biosynthesis, energy...
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PPAR Modulation Through Posttranslational Modification Control
The peroxisome proliferator-activated receptors (PPAR) are transcription factors modulated by ligands and members of the nuclear receptor...
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The amino acid metabolism is essential for evading physical plasma-induced tumour cell death
BackgroundRecent studies have emphasised the important role of amino acids in cancer metabolism. Cold physical plasma is an evolving technology...
