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Fetal safety of levetiracetam use during pregnancy
The aim of this study is to evaluate the effect of levetiracetam treatment during pregnancy on fetus.. The pregnant women with epilepsy (PWWE) who...
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Treatment Strategies for Alzheimer’s Disease-Associated Epilepsy: Past, Present, and Future Approaches
Numerous studies have established a probable bidirectional relationship between Alzheimer’s disease (AD) and epilepsy due to shared...
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Feasibility of Using Oral Fluid for Therapeutic Drug Monitoring of Antiepileptic Drugs
Therapeutic drug monitoring (TDM) of antiepileptic drugs (AED) using blood is well established but limited by its invasiveness, accessibility, cost,...
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Effects of Chronic Topiramate, Lacosamide, and Levetiracetam Pre-treatment on a Status Epilepticus Model in Rat Pups
We examined possible neuroprotective and prophylactic effects of chronic pre-treatment with levetiracetam (Lev), topiramate (Tpm), and lacosamide...
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Experimental Models for the Study of Drug-Resistant Epilepsy
Drug-resistant epilepsy is a major health problem that has not diminished despite the existence of new antiepileptic drugs. The use of appropriate...
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Different experiences of two PRRT2-associated self-limited familial infantile epilepsy
To analyze the clinical characteristics and PRRT2 gene mutation of self-limited familial infantile epilepsy and evaluate the treatment responses of...
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Inkjet and Binder Jet Printing in Pharmaceuticals
After three decades of foundational work, global interest remains ascendant for additive manufacturing (AM) of pharmaceuticals. At the forefront of...
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Physiology-Based Treatment of Myoclonus
Myoclonus can cause significant disability for patients. Myoclonus has a strikingly diverse array of underlying etiologies, clinical presentations,...
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Targeting synapse function and loss for treatment of neurodegenerative diseases
Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate with cognitive decline. However, the mechanisms and...
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Chronic Doxepin Toxicity Masquerading as Epilepsy in a 10-Year-Old Boy
IntroductionChronic tricyclic antidepressant toxicity is rarely described in children. Symptoms include confusion, ataxia, and seizures. Toxicity may...
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Effects of Levetiracetam on EEG Activity and Regularity of the Menstrual Cycle in Women Suffering from Epilepsy
Epilepsy itself and its treatment with anticonvulsants noticeably affect the reproductive function in women suffering from this disease....
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Epilepsy and Oxidative Stress
Epilepsy is one of the most common neurological condition reported worldwide. Oxidative stress and neuroinflammation have been strongly associated...
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The Brain Gene Registry: a data snapshot
Monogenic disorders account for a large proportion of population-attributable risk for neurodevelopmental disabilities. However, the data necessary...
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Efficacy and tolerability of lacosamide as adjunctive therapy in patients with focal-onset seizures: an observational, prospective study
PurposeTo evaluate the efficacy and tolerability of adjunctive lacosamide (LCM) in patients with focal-onset seizures, with or without combined...
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History and Present Scenario of Additive Manufacturing in Pharmaceuticals
Additive manufacturing also called 3D printing has provided a personalization front to the pharmaceutical industry where dosage development can be...
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SHQ1-associated neurodevelopmental disorder: Report of the first homozygous variant in unrelated patients and review of the literature
Compound heterozygous mutations in SHQ1 have been associated with a rare and severe neurological disorder characterized by global developmental delay...
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Seronegative acute encephalitis following COVID-19 vaccines: a case series of an overlooked diagnosis with literature review
PurposeAutoimmune encephalitis is a neurological emergency of new-onset altered mental status, caused by an exaggerated immune-mediated response that...
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Genes Involved in Pharmacoresistant Epilepsy
This chapter is devoted to drug-resistant epilepsy and its genetic mechanisms. There are currently six hypotheses proposed for pharmacoresistant...
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Seizures in COVID-19: the relationship between biomarkers and prognosis
ObjectiveTo assess the prevalence of seizure, associated risk factors, and prognosis in patients with SARS-CoV-2 infection and identify predictive...