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Epigenetic Regulation of Stress-Induced Visceral Pain
Persistent abdominal pain is the most important reason for patients with irritable bowel syndrome (IBS) to seek medical care. However, current...
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Evaluation of pediatric epigenetic clocks across multiple tissues
BackgroundEpigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational...
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The Genetic and Epigenetic Landscape of Cancer Stem Cells
Cancer stem cells (CSCs) possess the ability to self-renew, give rise to differentiated progeny, slowly replicate, and demonstrate resistance to...
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DNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort
BackgroundEpigenetic age acceleration (EAA) and epigenetic gestational age acceleration (EGAA) are biomarkers of physiological development and may be...
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Epigenetic regulation and therapeutic targets in the tumor microenvironment
The tumor microenvironment (TME) is crucial to neoplastic processes, fostering proliferation, angiogenesis and metastasis. Epigenetic regulations,...
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Modulation of Epigenetic Regulators for Cancer Prevention by Dietary Phytochemicals: Tools for Personalized Nutrition
Cancer is the most complex disease and is attributed to the accumulation of genetic and epigenetic alterations in cells from initiation to...
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From parental responsibility towards mutual understanding: reimagining the employment of epigenetic knowledge
This paper is interested in normative translations of findings in intergenerational epigenetics. Particularly, what role can and should epigenetic...
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Future in the past: paternal reprogramming of offspring phenotype and the epigenetic mechanisms
That certain preconceptual paternal exposures reprogram the developmental phenotypic plasticity in future generation(s) has conceptualized the...
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Clinical advances in epigenetic therapies for lymphoma
BackgroundAdvances in understanding of cancer biology, genomics, epigenomics, and immunology have resulted in development of several therapeutic...
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Epigenetic- and Epitranscriptomic-Targeted Reprogramming: Novel Targets for the Development of Broad-Spectrum Antivirals
Epigenetic and epitranscriptomic modifications have emerged as promising targets for the development of broad-spectrum antiviral therapies. These...
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Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study
BackgroundAortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely related to...
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Comprehensive analysis of epigenetic and epitranscriptomic genes’ expression in human NAFLD
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition with a complex etiology. Its incidence is increasing globally in parallel...
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Epigenetic Orchestration of Neurodegenerative Disorders: A Possible Target for Curcumin as a Therapeutic
Epigenetic modulations play a major role in gene expression and thus are responsible for various physiological changes including age-associated...
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New Data on the Pathophysiology of Ischemic Stroke: Epigenetic Mechanisms in Focus
Epigenetics is a branch of molecular biology studying modifications able to change the expression of genes without altering their DNA sequences....
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Causal association of epigenetic aging and osteoporosis: a bidirectional Mendelian randomization study
BackgroundThe relationship between aging and osteoporosis is well established. However, the relationship between the body's physiological age, i.e....
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DNA Methylation and Epigenetic Aging Biomarkers in Huntington’s Disease
DNA methylation is an epigenetic modification that plays critical roles in several important processes, including regulation of transcription,...
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Linking environmental risk factors with epigenetic mechanisms in Parkinson’s disease
Sporadic Parkinson’s disease (PD) is a progressive neurodegenerative disease, with a complex risk structure thought to be influenced by interactions...
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Epigenetic Regulators of NRF2
NRF2 is a key focus in cancer research because of its preventive/promotional roles depending on context. While NRF2 is largely activated by...
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Epigenetic Regulators of NRF2
NRF2 is a key focus in cancer research because of its preventive/promotional roles depending on context. While NRF2 is largely activated by...
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YAP represses intestinal inflammation through epigenetic silencing of JMJD3
BackgroundEpigenetics plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Some studies have reported that YAP is...
