Abstract
Cancer is the most complex disease and is attributed to the accumulation of genetic and epigenetic alterations in cells from initiation to progression. Since epigenetic changes are reversible, significant advances have been made in understanding how diet influences epigenetic mechanisms. Over the past decade, studies have been carried out to identify dietary bioactive components regulating multiple molecular cellular targets that modulate cancer. This chapter summarizes the existing data in cancer chemoprevention with dietary phytochemicals that can interfere with various epigenetic targets.
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Abbreviations
- AhR:
-
Aromatic hydrocarbon receptor
- Akt:
-
Protein kinase B
- DNA:
-
Deoxyribonucleic acid
- DNMTs:
-
DNA methyltransferases
- EC:
-
(−)-Epicatechin (EC)
- ECG:
-
(−)-Epicatechin-3-gallate (ECG)
- EGC:
-
(−)-Epigallocatechin (EGC)
- EGCG:
-
Epigallocatechin-3-gallate
- ER-α:
-
Estrogen receptor-alpha
- GSTP1:
-
Glutathione S-transferase Pi 1
- HATs:
-
Histone acetyl transferases
- HDAC:
-
Histone deacetylases
- hMLH1:
-
Human mutL homolog 1
- hTERT :
-
Human telomerase reverse transcriptase
- MBD2:
-
Methyl-CpG-binding domain protein 2
- MGMT:
-
O6-methylguanine-methyltransferase
- miRNAs:
-
MicroRNAs
- mRNA:
-
Messenger RNA
- NQO1:
-
NAD(P)H dehydrogenase [quinone]1
- Nrf2:
-
Nuclear factor erythroid 2-related factor 2
- PTEN:
-
Phosphatase and Tensin Homolog
- RAR-β :
-
Retinoic acid receptor-beta
- RNA:
-
Ribonucleic acid
- SAH:
-
S-adenosyl-l-homocysteine
- SAM:
-
S-adenosyl-l-methionine
- SNPs:
-
Single nucleotide polymorphisms
- SOCS1:
-
Suppressor of cytokine signaling 1
- SOCS3:
-
Suppressor of cytokine signaling 3
- TNBC:
-
Triple-negative breast cancer
- WHO:
-
World Health Organization
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Kaur, P., Sobti, R.C. (2024). Modulation of Epigenetic Regulators for Cancer Prevention by Dietary Phytochemicals: Tools for Personalized Nutrition. In: Sobti, R.C., Sugimura, H., Sobti, A. (eds) Molecular Biomarkers for Cancer Diagnosis and Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-99-3746-2_34
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