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Targeting Acid-Sensing Ion Channels in Disease
Acidosis is a central feature of many pathological conditions, and while the activity of many ion channels is suppressed under acidic conditions,...
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Quantitative imaging of apoptosis following oncolytic virotherapy by magnetic resonance fingerprinting aided by deep learning
Non-invasive imaging methods for detecting intratumoural viral spread and host responses to oncolytic virotherapy are either slow, lack specificity...
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Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria
The steady flow of lactic acid (LA) from tumor cells to the extracellular space via the monocarboxylate transporter symport system suppresses...
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Nanoparticle-Assisted Nuclear Relaxation-Based Detection of Oligonucleotides
Nuclear relaxation-based techniques rely on the capability of paramagnetic center to affect the transverse relaxation time (T2) of the water protons....
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Role of the voltage-gated proton channel Hv1 in insulin secretion, glucose homeostasis, and obesity
Diabetes is characterized by an absolutely inadequate insulin secretion (type 1 diabetes mellitus) or a relative deficit in insulin secretion due to...
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Potential of Magnetic Resonance (MR) Methods in Clinical Cancer Research
Magnetic resonance imaging (MRI) is often used as a versatile imaging modality for diagnosis of various diseases in clinical medicine. The technique...
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Fluorescent Carbon Dots: Aggregation-Induced Emission Enhancement, Application as Probe for CN− and Cr2O7−2, Sensing Strips and Bio-imaging Agent
Fluorescent carbon dots (Trp-CDs) were prepared using tryptophan as precursor and were characterized on the basis of elemental analysis, powder-XRD,...
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Analysis of Carbohydrates by Nuclear Magnetic Resonance Spectroscopy
NMR spectroscopy has shown to be extremely useful for the characterization of glycan structures. Carbohydrates have two natural NMR-active nuclei: 1H...
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Comparing biological effectiveness guided plan optimization strategies for cranial proton therapy: potential and challenges
BackgroundTo introduce and compare multiple biological effectiveness guided (BG) proton plan optimization strategies minimizing variable relative...
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A randomized controlled phase III study comparing hadrontherapy with carbon ions versus conventional radiotherapy – including photon and proton therapy – for the treatment of radioresistant tumors: the ETOILE trial
BackgroundSome cancers such as sarcomas (bone and soft tissue sarcomas) and adenoid cystic carcinomas are considered as radioresistant to low linear...
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Health-related quality of life and patient-reported symptoms after postoperative proton beam radiotherapy of cervical and endometrial cancer: 2-year results of the prospective phase II APROVE-trial
IntroductionThe APROVE-trial investigated the tolerability of postoperative proton beam therapy in women with cervical or endometrial cancer. The...
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Cyanine-based Fluorescent Probe for Cyanide Ion Detection
Cyanine-based probe-possessing indolium iodide and indole unit were synthesized in two-step with easy available raw material: a potential probe for...
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The V-ATPases in cancer and cell death
Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters that can be divided into F-, V-, and A-ATPases according to their...
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Neurogenic substance P—influences on action potential production in afferent neurons of the kidney?
We recently showed that a substance P (SP)–dependent sympatho-inhibitory mechanism via afferent renal nerves is impaired in mesangioproliferative...
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An NMR Relaxometer for Measuring Age-Related Muscle Loss
The paper describes a table-type NMR-relaxometer for measuring spin-spin relaxation times of protons in living tissues. The proton spin relaxation...
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Plasmodium falciparum: Transporter and Drug Target
Malaria will continue to be a concern for public health well into the future, as it is responsible for more than 50 million fatalities annually...
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Theoretical evaluation of a novel method for producing fluorine-18 for Positron-emission-tomography (PET) applications utilizing the 3He(d,p)4He reaction
A novel method of producing fluorine-18 for Positron emission tomography (PET) scan applications is evaluated theoretically. The method is based upon...
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GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior
Increased neural activities reduced pH at the synaptic cleft and interstitial spaces. Recent studies have shown that protons function as a...
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1D and 2D NMR for KRAS:Ligand Binding
Fragment-based screening by ligand-observed 1D NMR and binding interface map** by protein-observed 2D NMR are popular methods used in drug...
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MRI Data Analysis in Malformations of Cortical Development
Brain magnetic resonance imaging (MRI) is a noninvasive imaging modality that utilizes powerful magnets and radio waves to generate detailed images...