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Ion Channels as Targets in Drug Discovery

  • Book
  • © 2024

Overview

Editors:
  1. Gary Stephens

    1. School of Pharmacy, University of Reading, Reading, UK

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    You can also search for this editor in PubMed   Google Scholar

  2. Edward Stevens

    1. Metrion Biosciences Ltd., Cambridge, UK

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    You can also search for this editor in PubMed   Google Scholar

  • Examines current success stories in ion channel targets, bringing the concept of targeting ion channels
  • Discusses current major drug discovery programs in industry--for example, sodium channels in pain
  • Explores cutting-edge translational aspects of current ion channel research

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About this book

This book is built around ion channel research and, more specifically, ion channels as important therapeutic drug targets. Under the editorial leadership of Gary Stephens in academic research and Edward Stevens from industry, the aim is to bring these strands together to provide a cutting-edge translational reference on ion channel drug discovery.  Exploiting our knowledge of ion channel structure and function has clear current and future potential to intervene and correct the pathophysiology associated with debilitating conditions, including cardiovascular disease, diabetes, cystic fibrosis, pain, epilepsy, and neurodegenerative disorders. Individual chapters have a disease focus, also providing a “case study story” that will also appeal to a clinical audience, while background information on a given ion channel is presented to provide a solid reference for undergraduate and postgraduate teaching.

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-ix
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  2. Ion Channels as Targets in Drug Discovery: Outlook and Perspectives

    • Edward B. Stevens, Gary J. Stephens
    Pages 1-34

  3. Conservation of Ligand Binding Between Voltage-Gated Sodium and T-Type Calcium Channels

    • Rocio K. Finol-Urdaneta, Jeffrey R. McArthur, David J. Adams
    Pages 35-55

  4. The Presynaptic α2δ Protein Family and Their Therapeutic Potential

    • Cornelia Ablinger, Clarissa Eibl, Maria Roznovcova, Graeme S. Cottrell, Gary J. Stephens, Gerald J. Obermair
    Pages 57-89

  5. Voltage-Gated Sodium Channels as Drug Targets in Epilepsy-Related Sodium Channelopathies

    • Eric R. Wengert, Raquel M. Miralles, Manoj K. Patel
    Pages 91-114

  6. Therapeutic Targeting of Potassium Channels

    • Nikita Gamper, Dongyang Huang, **long Qi, Lilong Dong, Hailin Zhang
    Pages 115-198

  7. The Contribution of Genetic Sequencing Information to the Identification and Functional Characterization of Two-Pore Domain Potassium (K2P) Channels as Viable Therapeutic Targets

    • Alistair Mathie, Samuel R. Bourne, Rachel Forfar, Walter E. Perfect, Emma L. Veale
    Pages 199-220

  8. The Voltage-Gated Potassium Channel Kv2.1 as a Multicellular Drug Target

    • Moza M. Al-Owais, Nagihan Ozsoy, Mark L. Dallas
    Pages 221-237

  9. Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Targeted Therapeutics for Cystic Fibrosis

    • Diana-Florentina Veselu, Han-I Yeh, Mayuree Rodrat, Jacob D. Bradbury, Yanira Manzanares Fornies, Hongyu Li et al.
    Pages 239-284

  10. Validation of TMEM16A Modulation as a Therapeutic Approach for the Treatment of Cystic Fibrosis: The Discovery of Novel TMEM16A Potentiators

    • Henry Danahay, Martin Gosling
    Pages 285-302

  11. Targeting Acid-Sensing Ion Channels in Disease

    • Victor Senescall, Elena Budusan, Adriana Knezic, Maleeha Waqar, Neville Butcher, Nemat Khan et al.
    Pages 303-355

  12. Transient Receptor Potential Canonical (TRPC) as a Therapeutic Drug Target

    • Hussein N. Rubaiy
    Pages 357-388

  13. Nicotinic Receptors of the Neuronal and Non-neuronal Cholinergic Systems as Therapeutic Targets: Opportunities and Limitations

    • Sue Wonnacott
    Pages 389-437

  14. Purinergic P2X Receptors as Therapeutic Targets

    • Leanne Stokes, Stefan Bidula, Ronald Sluyter
    Pages 439-460

  15. Immune Cell Ion Channels as Therapeutic Targets

    • Anna Selezneva, Alasdair J. Gibb, Dean Willis
    Pages 461-495

  16. Ion Channel Tools and Therapeutics from Venoms and Toxins

    • Carol M. Trim, Abba E. Leffler, Ziyana Samanani, Steven A. Trim
    Pages 497-534

  17. Back Matter

    Pages 535-537
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Editors and Affiliations

  • School of Pharmacy, University of Reading, Reading, UK

    Gary Stephens

  • Metrion Biosciences Ltd., Cambridge, UK

    Edward Stevens

About the editors

Gary Stephens is Professor of Pharmacology at the School of Pharmacy, University of Reading, United Kingdom.  He is an in vitro electrophysiologist with an interest in voltage-gated calcium channels and G protein-coupled receptors.  He is a Senior Editor with the British Journal of Pharmacology and is on the Editorial Board of Pharmaceuticals.


Edward Stevens is Chief Scientific Officer at Metrion Biosciences and has over 20 years’ experience of ion channel drug discovery within the biotech/pharma field.

Bibliographic Information

  • Book Title: Ion Channels as Targets in Drug Discovery

  • Editors: Gary Stephens, Edward Stevens

  • DOI: https://doi.org/10.1007/978-3-031-52197-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2024

  • Hardcover ISBN: 978-3-031-52196-6Published: 25 April 2024

  • Softcover ISBN: 978-3-031-52199-7Due: 26 May 2024

  • eBook ISBN: 978-3-031-52197-3Published: 24 April 2024

  • Edition Number: 1

  • Number of Pages: IX, 537

  • Number of Illustrations: 26 b/w illustrations, 62 illustrations in colour

  • Topics: Neurosciences, Neurochemistry, Pharmacology/Toxicology

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