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Article
Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting
Here we show that fusion of two complementarity-determining regions (CDRs), VHCDR1 and VLCDR3, through a cognate framework region (VHFR2) yields mimetics that retain the antigen recognition of their parent molecu...
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Article
Association of polymorphisms in the human IL-10 and IL-18 genes with rheumatoid arthritis
The decrease of anti-inflammatory cytokine and increase of pro-inflammatory cytokine was observed in rheumatoid arthritis (RA). Interleukin-10 (IL-10), a potent anti-inflammatory cytokine, has been demonstrate...
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Article
Association of pre-microRNAs genetic variants with susceptibility in systemic lupus erythematosus
MicroRNAs (miRNAs) may play important roles in SLE, but genetic polymorphisms of miRNAs and their relationships with various autoantibodies present in SLE patients remain unclear. Here, we report that 213 SLE ...
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Article
Association study of single nucleotide polymorphisms in pre-miRNA and rheumatoid arthritis in a Han Chinese population
The aim of this study was to perform an association study between two single nucleotide polymorphisms (SNPs) rs2910164 G>C and rs3746444 T>C in pre-miRNA (hsa-mir-146a and hsa-mir-499) and rheumatoid arthritis...
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Article
Disturbed Th17/Treg balance in patients with rheumatoid arthritis
Proinflammatory Th17 cells and CD4+CD25+ regulatory T (Treg) cells are two newly identified T lymphocyte subsets, which have opposite effects on autoimmunity and inflammation. To assess the Th17/Treg pattern and ...
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Article
Surface/interface effects on dispersion relations of 2D phononic crystals with parallel nanoholes or nanofibers
Owing to the increasing ratio of surface to bulk volume, surface effects emerge in the mechanical performance of devices and materials when the characteristic size reduces to nanoscale. In this paper, the disp...
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Chapter and Conference Paper
Research on Automatic Layout Planning and Performance Analysis System of Production Line Based on Simulation
The automatic layout planning and performance analysis of production system is important and key technology to manufacturing enterprise to response market demand. The factors of system configuration, productio...
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Article
Open AccessGeneration of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system
Recent advances in the study of the CRISPR/Cas9 system have provided a precise and versatile approach for genome editing in various species. However, the applicability and efficiency of this method in large an...
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Article
Open AccessEpidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China
Hepatitis B virus (HBV) infection is a critical global health issue and moderately epidemic in Western China, but HBV molecular epidemiology characteristics are still limited. We conducted this study to invest...
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Article
Open AccessCorrection: Corrigendum: Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China
Hepatitis B virus (HBV) infection is a critical global health issue and moderately epidemic in Western China, but HBV molecular epidemiology characteristics are still limited. We conducted this study to invest...
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Article
Open AccessPathway Analyses Identify Novel Variants in the WNT Signaling Pathway Associated with Tuberculosis in Chinese Population
Tuberculosis remains a global public health problem, and its immunopathogenesis is still poorly understood. In this study, 25 single nucleotide polymorphisms (SNPs) in the WNT pathway were evaluated in relatio...
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Article
Open AccessMultiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep
The CRISPR/Cas9 system provides a flexible approach for genome engineering of genetic loci. Here, we successfully achieved precise gene targeting in sheep by co-injecting one-cell-stage embryos with Cas9 mRNA ...
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Article
Open AccessGenetic Polymorphisms of rs3077 and rs9277535 in HLA-DP associated with Systemic lupus erythematosus in a Chinese population
Although the SLE risk gene loci of HLA-DR and HLA-DQ within the major histocompatibility complex (MHC) region has been gradually revealed by recent Genome-Wide Association studies (GWAS), the association of HLA-D...
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Article
Tβ4-overexpression based on the piggyBac transposon system in cashmere goats alters hair fiber characteristics
Increasing cashmere yield is one of the vital aims of cashmere goats breeding. Compared to traditional breeding methods, transgenic technology is more efficient and the piggyBac (PB) transposon system has been...
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Article
Open AccessMitochondrial C11orf83 is a potent Antiviral Protein Independent of interferon production
Mitochondria have a central position in innate immune response via the adaptor protein MAVS in mitochondrial outer membrane to limit viral replication by inducing interferon production. Here, we reported that ...
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Article
Genetic polymorphism of rs9277535 in HLA-DP associated with rheumatoid arthritis and anti-CCP production in a Chinese population
HLA-II molecules are critical in triggering human immune response, especially in activating CD4+ T cells. HLA-DP, belonging to HLA-II molecules, draws increasing attention for its role in presentation of viral...
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Article
Atomistic simulation study of favored compositions of Ni-Nb-Al metallic glasses
This study investigates the formation process of Ni-Nb-Al metallic glasses. To this end, a long-range n-body potential was constructed for the Ni-Nb-Al ternary metal system, and applied to atomistic simulations. ...
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Article
Open AccessThe establishment of neuron-specific enolase reference interval for the healthy population in southwest China
To investigate and establish a reference interval (RI) of neuron-specific enolase (NSE) in southwest China’s healthy population by using the laboratory information system database. A total of 86957 periodic he...
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Article
Open AccessOptimized Cas9:sgRNA delivery efficiently generates biallelic MSTN knockout sheep without affecting meat quality
CRISPR/Cas9-based genome-editing systems have been used to efficiently engineer livestock species with precise genetic alterations intended for biomedical and agricultural applications. Previously, we have suc...
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Article
Association of the MARCO polymorphism rs6761637 with hepatocellular carcinoma susceptibility and clinical characteristics
Hepatocellular carcinoma (HCC) remains a significant health problem with a substantial genetic predisposition. The liver harbors the largest proportion of macrophages among all the solid organs. There is consi...
