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Article
Open AccessAn oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy
Tumor-specific T cells are crucial in anti-tumor immunity and act as targets for cancer immunotherapies. However, these cells are numerically scarce and functionally exhausted in the tumor microenvironment (TM...
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Article
Open AccessExploring the relationship between Treg-mediated risk in COPD and lung cancer through Mendelian randomization analysis and scRNA-seq data integration
Evidence from observational studies suggests an association between chronic obstructive pulmonary disease (COPD) and lung cancer. The potential interactions between the immune system and the lungs may play a c...
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Article
Open AccessAuthor Correction: Tumor-specific memory CD8+ T cells are strictly resident in draining lymph nodes during tumorigenesis
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Article
Open AccessClostridioides difficile infection in infants: a case report and literature review
Clostridioides difficile (C. difficile) is the major pathogen causing antibiotic-associated diarrhea. There are a variety of symptoms associated with C. difficile infection (CDI) in adults, including self-limitin...
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Article
Dual-Mode Metamaterial Absorber for Independent Sweat and Temperature Sensing
Metamaterial absorbers are increasingly studied and applied in sensing, telemedicine, and health monitoring applications. At present, many reported metamaterial-based sensors often exhibit the characteristics ...
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Article
Open AccessTumor-specific memory CD8+ T cells are strictly resident in draining lymph nodes during tumorigenesis
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Article
A hybrid Wavelet-CNN-LSTM deep learning model for short-term urban water demand forecasting
Short-term water demand forecasting provides guidance on real-time water allocation in the water supply network, which help water utilities reduce energy cost and avoid potential accidents. Although a variety ...
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Article
The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis
Antigen-specific memory CD4+ T cells can persist and confer rapid and efficient protection from microbial reinfection. However, the mechanisms underlying the long-term maintenance of the memory CD4+ T cell pool r...
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Article
Removal of Fluorine from Zinc Electrolyte by Cerium Silicate
The impurity fluorine in zinc electrolytic system can severely affect the production of zinc. In this study, six silicate adsorbents were synthesized and applied to the removal of fluorine from the synthesized...
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Article
Extraction of Molybdenum from Spent HDS Catalyst by Pressure Alkaline Leaching
Molybdenum bearing spent hydrodesulphurization (HDS) catalyst is an important secondary resource. In the present research, the extraction of molybdenum from the roasted spent HDS catalyst was investigated by p...
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Article
Study on the mechanisms of the cross-resistance to TET, PIP, and GEN in Staphylococcus aureus mediated by the Rhizoma Coptidis extracts
The purpose of this study was focused on the mechanisms of the cross-resistance to tetracycline (TET), piperacillin Sodium (PIP), and gentamicin (GEN) in Staphylococcus aureus (SA) mediated by Rhizoma Coptidis ex...
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Article
Open AccessThe lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling
The efficient induction and long-term persistence of pathogen-specific memory CD8 T cells are pivotal to rapidly curb the reinfection. Recent studies indicated that long-noncoding RNAs expression is highly cel...
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Article
Open AccessThe dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity
The adaptive immunity that protects patients from coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is not well characterized. In particular, the asym...
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Article
Open AccessDisease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19
COVID-19 patients exhibit differential disease severity after SARS-CoV-2 infection. It is currently unknown as to the correlation between the magnitude of neutralizing antibody (NAb) responses and the disease ...
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Article
Open AccessHuman monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor
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Article
Open AccessThe histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection
Epigenetic modifications to histones dictate the differentiation of naïve CD4+ T cells into different subsets of effector T helper (TH) cells. The histone methyltransferase enhancer of zeste homolog 2 (EZH2) has ...
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Article
Open AccessCombination of the natural compound Periplocin and TRAIL induce esophageal squamous cell carcinoma apoptosis in vitro and in vivo: Implication in anticancer therapy
Esophageal cancer is one of the most common malignant tumors in the world. With currently available therapies, only 20% ~ 30% patients can survive this disease for more than 5 years. TRAIL, a natural ligand fo...
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Article
Open AccessExosomal lncRNA ZFAS1 regulates esophageal squamous cell carcinoma cell proliferation, invasion, migration and apoptosis via microRNA-124/STAT3 axis
In recent years, long non-coding RNAs (lncRNAs) are of great importance in development of different types of tumors, while the function of lncRNA ZFAS1 is rarely discussed in esophageal squamous cell carcinoma...
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Chapter and Conference Paper
Persuasive Design and Application of Intelligent Healthcare Product
Intelligent healthcare is an emerging interdisciplinary field combining medical field, network technology and interaction and service design (Joseph, Ahn, Kim et al. 2005; Ma, Wang, Zhou et al. 2018). It is al...
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Protocol
Analyzing Mouse B Cell Responses Specific to LCMV Infection
B cell responses play a central role in humoral immunity, which protects an individual from invading pathogens by antigen-specific antibodies. Understanding the basic principles of the B cell responses during ...
