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Article
A Novel Coupled Model for Monthly Rainfall Prediction Based on ESMD-EWT-SVD-LSTM
Precise predicting of rainfall is paramount for effective water resource management, ecological conservation, and the prevention of droughts and floods. Influenced by numerous variables, the process of rainfal...
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Article
Artificial intelligence for neuro MRI acquisition: a review
To review recent advances of artificial intelligence (AI) in enhancing the efficiency and throughput of the MRI acquisition workflow in neuroimaging, including planning, sequence design, and correction of acqu...
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Article
Cadonilimab with chemotherapy in HER2-negative gastric or gastroesophageal junction adenocarcinoma: the phase 1b/2 COMPASSION-04 trial
Treatment with anti-programmed cell death protein 1 (PD-1) therapy and chemotherapy prolongs the survival of patients with unresectable advanced or metastatic gastric or gastroesophageal junction (GEJ) adenoca...
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Article
Open AccessAn oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy
Tumor-specific T cells are crucial in anti-tumor immunity and act as targets for cancer immunotherapies. However, these cells are numerically scarce and functionally exhausted in the tumor microenvironment (TM...
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Article
Open AccessPerioperative versus adjuvant S-1 plus oxaliplatin chemotherapy for stage II/III resectable gastric cancer (RESONANCE): a randomized, open-label, phase 3 trial
Evidence from Europe shows that perioperative chemotherapy may be beneficial for the treatment of locally advanced gastric cancer, but reliable and robust data is lacking. To rectify this, the phase 3 RESONANC...
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Article
Open AccessSafety and short-term outcomes of a modified valvuloplastic esophagogastrostomy versus gastric tube anastomosis after laparoscopy-assisted proximal gastrectomy: a retrospective cohort study
There is no optimal reconstruction method after proximal gastrectomy. The valvuloplastic esophagogastrostomy can reduce postoperative reflux esophagitis, but it is technically complex with a long operation tim...
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Article
Structural insight into selectivity of amylin and calcitonin receptor agonists
Amylin receptors (AMYRs), heterodimers of the calcitonin receptor (CTR) and one of three receptor activity-modifying proteins, are promising obesity targets. A hallmark of AMYR activation by Amy is the formati...
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Article
Open AccessShort-term outcomes and long-term quality of life of reconstruction methods after proximal gastrectomy: a systematic review and meta-analysis
The optimal reconstruction method after proximal gastrectomy remains unclear. This systematic review and meta-analysis aimed to compare the short-term outcomes and long-term quality of life of various reconstr...
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Article
Open AccessHuogu injection protects against SONFH by promoting osteogenic differentiation of BMSCs and preventing osteoblast apoptosis
To investigate the effect and mechanism of Huogu injection (HG) on steroid-induced osteonecrosis of the femoral head (SONFH), we established a SONFH model in rabbits using horse serum and dexamethasone (DEX) a...
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Article
Open AccessAlgorithm for optimized mRNA design improves stability and immunogenicity
Messenger RNA (mRNA) vaccines are being used to combat the spread of COVID-19 (refs. 1–3), but they still exhibit critical limitations caused by mRNA instability and degradation, which are major obstacles for the...
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Article
Open AccessPredicting delayed methotrexate elimination in pediatric acute lymphoblastic leukemia patients: an innovative web-based machine learning tool developed through a multicenter, retrospective analysis
High-dose methotrexate (HD-MTX) is a potent chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia (ALL). HD-MTX is known for cause delayed elimination and drug-related adverse events. The...
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Article
Open AccessEfficacy of chemotherapy versus surgery as initial treatment for gastric cancer with positive peritoneal cytology
The prognosis of gastric cancer (GC) patients with positive peritoneal cytology (CY1) without other distant metastasis is poor, and there are no standard treatment strategies. Our study aimed to compare the su...
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Article
Microstructure Evolution of Polycrystalline Zinc during Tensile Testing at Room Temperature
In this paper, a pure zinc sample was prepared by extrusion at room temperature and its microstructure evolution during tensile testing was studied by electron back-scattering diffraction (EBSD). The average g...
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Article
Drying characteristics and neural network models of contact ultrasound strengthened cold air drying on yam
In order to explore the strengthening effect of contact ultrasound on cold air drying(CAD) of yam, contact ultrasound strengthened cold air drying (CUCAD) experiments were carried out. The effects of ultrasoni...
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Article
Soft magnetic properties and loss performance of Co2O3-doped power MnZn ferrite at 100–300 kHz
In this study, a Co2O3 addition from 0.28 to 0.44 wt% is added to the MnZn ferrites. The effects of Co2O3 on the soft magnetic properties and loss performance of the MnZn ferrites were investigated over a wide te...
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Article
Open AccessField-measured canopy height may not be as accurate and heritable as believed: evidence from advanced 3D sensing
Canopy height (CH) is an important trait for crop breeding and production. The rapid development of 3D sensing technologies shed new light on high-throughput height measurement. However, a systematic compariso...
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Article
An exploration of gastric cancer with heterogeneous mismatch repair status
Survival benefits or symptom alleviation from immune checkpoint blockade therapy can be seen in microsatellite instability-high (MSI-H) cases. However, genetic heterogeneity within a specific subgroup of MSI-H...
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Article
Myelin Debris Impairs Tight Junctions and Promotes the Migration of Microvascular Endothelial Cells in the Injured Spinal Cord
Clearance of myelin debris caused by acute demyelination is an essential process for functional restoration following spinal cord injury (SCI). Microvascular endothelial cells, acting as “amateur” phagocytes, ...
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Article
Open AccessKAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells
Epigenetic mechanisms involved in gene expression play an essential role in various cellular processes, including lipid metabolism. Lysine acetyltransferase 8 (KAT8), a histone acetyltransferase, has been repo...
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Chapter and Conference Paper
Macaroni: Crawling and Enriching Metadata from Public Model Zoos
Machine learning (ML) researchers and practitioners are building repositories of pre-trained models, called model zoos. These model zoos contain metadata that detail various properties of the ML models and datase...
