43 Result(s)

Article

Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity

Natural killer (NK) cells play a crucial role in immune response against viral infections and tumors. However, further investigation is needed to better understand the key molecules responsible for determining...

Peiran Feng, Liang Luo, Quanli Yang, Wanqing Meng, Zerong Guan… in Cell Death & Disease (2024)

Article

Author Correction: Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression

Qiang Zhang, **aoya Yang, **jie Wu, Shubiao Ye, Junli Gong… in Cell Discovery (2023)

Article

Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression

Metabolic reprogramming is a hallmark of cancer. However, it is not well known how metabolism affects cancer progression. We identified that metabolic enzyme acyl-CoA oxidase 1 (ACOX1) suppresses colorectal ca...

Qiang Zhang, **aoya Yang, **jie Wu, Shubiao Ye, Junli Gong… in Cell Discovery (2023)

Article

Airway microecology in rifampicin-resistant and rifampicin-sensitive pulmonary tuberculosis patients

Pulmonary tuberculosis is a chronic infectious disease of the respiratory system. It is still one of the leading causes of death from a single infectious disease, but it has been stuck in the study of a single...

**ngshan Cai, Yang Luo, Yuanliang Zhang, Yuan Lin, Bitong Wu… in BMC Microbiology (2022)

Article

SMYD2 aggravates gastrointestinal stromal tumor via upregulation of EZH2 and downregulation of TET1

SMYD2, as an oncogene, has been involved in multiple types of cancer, but the potential role of SMYD2 in gastrointestinal stromal tumors (GIST) remains enigmatic and requires further investigation. Hence, this...

Yong Ji, **aofeng Xu, Cong Long, Jianjiang Wang, Li Ding… in Cell Death Discovery (2022)

Article

Gene losses may contribute to subterranean adaptations in naked mole-rat and blind mole-rat

Naked mole-rats (Heterocephalus glaber, NMRs) and blind mole-rats (Spalax galili, BMRs) are representative subterranean rodents that have evolved many extraordinary traits, including hypoxia tolerance, longevity,...

Zhizhong Zheng, Rong Hua, Guoqiang Xu, Hui Yang, Peng Shi in BMC Biology (2022)

Article

Integrated analysis of high-throughput sequencing data reveals the key role of LINC00467 in the invasion and metastasis of testicular germ cell tumors

Long noncoding RNAs (lncRNAs) are involved in various physiological and pathological processes. However, the role of lncRNAs in testicular germ cell tumor (TGCT) has been rarely reported. Our purpose is to com...

Hao Bo, Fang Zhu, Zhizhong Liu, Qi Deng, Guangmin Liu, Ruixue Li… in Cell Death Discovery (2021)

Article

TRIM25 regulates oxaliplatin resistance in colorectal cancer by promoting EZH2 stability

Resistance to chemotherapy remains the major cause of treatment failure in patients with colorectal cancer (CRC). Here, we identified TRIM25 as an epigenetic regulator of oxaliplatin (OXA) resistance in CRC. T...

Sha Zhou, Jianhong Peng, Liuniu **ao, Caixia Zhou, Yu**g Fang… in Cell Death & Disease (2021)

Article

Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis

Ankylosing spondylitis (AS) is a chronic inflammatory disease possessing a morbid serum microenvironment with enhanced oxidative stress. Long-term exposure to an oxidative environment usually results in cellul...

Guiwen Ye, Zhongyu **e, Huiqiong Zeng, Peng Wang, **teng Li… in Cell Death & Disease (2020)

Article

High-resolution map** of quantitative trait loci controlling main floral stalk length in Chinese cabbage (Brassica rapa L. ssp. pekinensis)

For spring-type Chinese cabbage production, premature bolting refers to the excessive elongation of dwarf stems before harvesting. Although quantitative trait loci (QTL) map** for bolting-related traits have...

Shuantao Liu, Ronghua Wang, Zhigang Zhang, Qiaoyun Li, Lihua Wang… in BMC Genomics (2019)

Article

Acidosis enhances the self-renewal and mitochondrial respiration of stem cell-like glioma cells through CYP24A1-mediated reduction of vitamin D

Acidosis is a significant feature of the tumor microenvironment in glioma, and it is closely related to multiple biological functions of cancer stem cells. Here, we found that the self-renewal ability, the mit...

Peishan Hu, Shanshan Li, Ningyu Tian, Fan Wu, Yan Hu, Dengke Li… in Cell Death & Disease (2019)

Article

DR-region of Na⁺/K⁺ ATPase is a target to treat excitotoxicity and stroke

Na⁺/K⁺ ATPase (NKA) is important in maintaining cellular functions. We found that loss of NKA activities in NKAα1^+/− mice is associated with increased susceptibility to ischemic injuries following transient middl...

Meimei Shi, Lei Cao, Xu Cao, Mengyuan Zhu, … in Cell Death & Disease (2018)

Article

RNF183 promotes proliferation and metastasis of colorectal cancer cells via activation of NF-κB-IL-8 axis

Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, which is a heterogeneous disease and main risk factors are associated with inflammation, family history, genetic mutations, epigene...

Rong Geng, **n Tan, Jiangxue Wu, Zhizhong Pan, Min Yi, Wei Shi… in Cell Death & Disease (2017)

Article

PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407

Colorectal cancer (CRC) is the third most common cause of cancer deaths, and has a high rate of liver and lung metastasis. Unfortunately, distant metastasis is the main barrier for advanced CRC therapy and lea...

**n Tan, Shuai Chen, Jiangxue Wu, Jiaxin Lin, Changchuan Pan… in Cell Death & Disease (2017)