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Article
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers in the world. The therapeutic outlook for HCC patients has significantly improved with the advent and development of systematic and t...
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Article
NνDEx-100 conceptual design report
Observing nuclear neutrinoless double beta (0 \(\nu \beta \beta\) ν ...
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Article
Single-cell RNA sequencing deciphers the mechanism of sepsis-induced liver injury and the therapeutic effects of artesunate
Liver, as an immune and detoxification organ, represents an important line of defense against bacteria and infection and a vulnerable organ that is easily injured during sepsis. Artesunate (ART) is an anti-mal...
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Article
Secondary Metabolites of the Endophytic Fungi Talaromyces flavus Cultivated in Pumpkin Medium and Their Bioactivity
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Article
Open AccessTPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs
The pregnane X receptor (PXR) is an important regulator of hepatocellular carcinoma cellular resistance to antitumor drugs. Activation of PXR was modulated by the co-regulators. The target protein for the Xeno...
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Article
Maintaining temporal validity of real-time data in component-based systems
How to schedule the sensor transactions to maintain the temporal validity of real-time data is an important research issue for cyber-physical systems. Current studies on sensor transaction scheduling assume th...
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Article
Open AccessIdentification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA
Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in develo** countries. In the history of anti-malaria campaign, chloroquine (CQ) has played an indi...
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Article
Open AccessCelastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol (Cel) is a natural anti-inflamm...
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Article
Effects of Ho nanopowders intergranular addition on microstructure and properties of sintered Nd–Fe–B
Nd–Fe–B magnetic materials were prepared using the binary alloy method with addition of Ho nanopowder to grain boundaries to improve the magnetic, mechanical properties, and corrosion-resistant performance. Th...
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Article
A rapid and accurate method for identifying sexuality of Indarbela obliquifasciata Mell (Lepidoptera, Metarbelidae) adults and pupae
The bark-eating caterpillar, Indarbela obliquifasciata Mell has become a major pest of garden plants in Guangzhou, China. However, little is known about the sex identification of either adults or pupae. In this p...
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Article
Antibody responses to SARS-CoV-2 in patients with COVID-19
We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG...
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Article
Open AccessPRMT1 promotes neuroblastoma cell survival through ATF5
Aberrant expression of protein arginine methyltransferases (PRMTs) has been implicated in a number of cancers, making PRMTs potential therapeutic targets. But it remains not well understood how PRMTs impact sp...
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Article
Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla
In the present study, nine compounds (1–9) were isolated from Colletotrichum gloeosporioides (an endophytic fungus from Uncaria rhynchophylla) which was cultured in wheat bran medium. Their structures were elucid...
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Article
HDAC-selective Inhibitor Cay10603 Has Single Anti-tumour Effect in Burkitt’s Lymphoma Cells by Impeding the Cell Cycle
Histone deacetylases (HDACs) inhibitors are novel in cancer therapy nowadays. HDAC6-selective inhibitors exert advantageous effects due to higher selectivity and less toxicity. We explored the anti-tumor effec...
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Article
Linear dipole behavior of single quantum dots encased in metal oxide semiconductor nanoparticles films
Understanding of charge/energy exchange processes and interfacial interactions that occur between quantum dots (QDs) and the metal oxides is of critical importance to these QD-based optoelectronic devices. Thi...
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Reference Work Entry In depth
Regulator of G Protein Signaling 5 (RGS5)
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Article
De novo induction of intratumoral lymphoid structures and vessel normalization enhances immunotherapy in resistant tumors
Ganss and colleagues show that targeting the inflammatory cytokine LIGHT to tumor vessels via a vascular targeting peptide induces tertiary lymphoid structures and enables the influx of endogenous T cells and ...
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Article
Improved microwave absorption properties of core–shell type Ni@SiC nanocomposites
SiC coated Ni nanocomposites were fabricated by a facile arc-discharge method. XRD, HRTEM and XPS technologies indicate that as-prepared Ni@SiC nanocomposites consist of the Ni nanoparticles core and shells co...
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Article
An unusual Lophodermium species on needles of Pinus taiwanensis from China
An interesting fungus, which appeared to resemble a contaminated or infected Lophodermium species, is described and illustrated in this paper. The circinate apex of paraphyses, which intertwined with each other, ...
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Article
Open AccessVascular-targeted TNFα and IFNγ inhibits orthotopic colorectal tumor growth
Tumor necrosis factor alpha (TNFα) and interferon gamma (IFNγ) were originally identified to show potent anti-tumor activity and immunomodulatory capability. Unfortunately, several clinical studies of relevant...