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  1. No Access

    Article

    Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers in the world. The therapeutic outlook for HCC patients has significantly improved with the advent and development of systematic and t...

    Fan Yang, Lin Jia, Hong-chao Zhou, **g-nan Huang in Acta Pharmacologica Sinica (2024)

  2. No Access

    Article

    NνDEx-100 conceptual design report

    Observing nuclear neutrinoless double beta (0 \(\nu \beta \beta\) ν ...

    **-Guang Cao, Yan-Long Chang, Kai Chen, Emilio Ciuffoli in Nuclear Science and Techniques (2023)

  3. No Access

    Article

    Single-cell RNA sequencing deciphers the mechanism of sepsis-induced liver injury and the therapeutic effects of artesunate

    Liver, as an immune and detoxification organ, represents an important line of defense against bacteria and infection and a vulnerable organ that is easily injured during sepsis. Artesunate (ART) is an anti-mal...

    Xue-ling He, Jia-yun Chen, Yu-lin Feng, ** Song in Acta Pharmacologica Sinica (2023)

  4. No Access

    Article

    Secondary Metabolites of the Endophytic Fungi Talaromyces flavus Cultivated in Pumpkin Medium and Their Bioactivity

    Zhong-Duo Yang, Jia-jun Ma, Zhi-Jie Li, Jun-bo ** in Chemistry of Natural Compounds (2023)

  5. Article

    Open Access

    TPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs

    The pregnane X receptor (PXR) is an important regulator of hepatocellular carcinoma cellular resistance to antitumor drugs. Activation of PXR was modulated by the co-regulators. The target protein for the Xeno...

    Hongbo Wang, Fang Chu, **ao-feng Zhang, Peng Zhang, Li-xin Li in Cell Death & Disease (2023)

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    Article

    Maintaining temporal validity of real-time data in component-based systems

    How to schedule the sensor transactions to maintain the temporal validity of real-time data is an important research issue for cyber-physical systems. Current studies on sensor transaction scheduling assume th...

    Tian Bai, Zhi-Jie Li, Bo Fan, Jun Liao in Computing (2022)

  7. Article

    Open Access

    Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA

    Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in develo** countries. In the history of anti-malaria campaign, chloroquine (CQ) has played an indi...

    Peng Gao, Yan-Qing Liu, Wei **ao, Fei **a, Jia-Yun Chen in Military Medical Research (2022)

  8. Article

    Open Access

    Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect

    Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol (Cel) is a natural anti-inflamm...

    Piao Luo, Qian Zhang, Tian-Yu Zhong, Jia-Yun Chen in Military Medical Research (2022)

  9. No Access

    Article

    Effects of Ho nanopowders intergranular addition on microstructure and properties of sintered Nd–Fe–B

    Nd–Fe–B magnetic materials were prepared using the binary alloy method with addition of Ho nanopowder to grain boundaries to improve the magnetic, mechanical properties, and corrosion-resistant performance. Th...

    Hong-Zhi Wang, Zhi-Jie Li, Zheng Liu, Yan Yan in Journal of Nanoparticle Research (2021)

  10. No Access

    Article

    A rapid and accurate method for identifying sexuality of Indarbela obliquifasciata Mell (Lepidoptera, Metarbelidae) adults and pupae

    The bark-eating caterpillar, Indarbela obliquifasciata Mell has become a major pest of garden plants in Guangzhou, China. However, little is known about the sex identification of either adults or pupae. In this p...

    Li-Zhi Huo, Long-Hua Sun, **g-Ai Zhang in International Journal of Tropical Insect S… (2021)

  11. Article

    Antibody responses to SARS-CoV-2 in patients with COVID-19

    We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG...

    Quan-**n Long, Bai-Zhong Liu, Hai-Jun Deng, Gui-Cheng Wu, Kun Deng in Nature Medicine (2020)

  12. Article

    Open Access

    PRMT1 promotes neuroblastoma cell survival through ATF5

    Aberrant expression of protein arginine methyltransferases (PRMTs) has been implicated in a number of cancers, making PRMTs potential therapeutic targets. But it remains not well understood how PRMTs impact sp...

    Zhong-Yan Hua, Jeanne N. Hansen, Miao He, Shang-Kun Dai, Yoonjung Choi in Oncogenesis (2020)

  13. No Access

    Article

    Secondary Metabolites and PI3K Inhibitory Activity of Colletotrichum gloeosporioides, a Fungal Endophyte of Uncaria rhynchophylla

    In the present study, nine compounds (1–9) were isolated from Colletotrichum gloeosporioides (an endophytic fungus from Uncaria rhynchophylla) which was cultured in wheat bran medium. Their structures were elucid...

    Zhong-Duo Yang, Zhi-Jie Li, Jun-Wen Zhao, Jian-Hui Sun, Li-Jun Yang in Current Microbiology (2019)

  14. No Access

    Article

    HDAC-selective Inhibitor Cay10603 Has Single Anti-tumour Effect in Burkitt’s Lymphoma Cells by Impeding the Cell Cycle

    Histone deacetylases (HDACs) inhibitors are novel in cancer therapy nowadays. HDAC6-selective inhibitors exert advantageous effects due to higher selectivity and less toxicity. We explored the anti-tumor effec...

    **u-juan Ma, Gang Xu, Zhi-jie Li, Fang Chen, Di Wu in Current Medical Science (2019)

  15. No Access

    Article

    Linear dipole behavior of single quantum dots encased in metal oxide semiconductor nanoparticles films

    Understanding of charge/energy exchange processes and interfacial interactions that occur between quantum dots (QDs) and the metal oxides is of critical importance to these QD-based optoelectronic devices. Thi...

    Guo-Feng Zhang, Yong-Gang Peng, Hai-Qing **e, Bin Li, Zhi-Jie Li in Frontiers of Physics (2018)

  16. No Access

    Reference Work Entry In depth

    Regulator of G Protein Signaling 5 (RGS5)

    Zhi-Jie Li, Ruth Ganss in Encyclopedia of Signaling Molecules (2018)

  17. No Access

    Article

    De novo induction of intratumoral lymphoid structures and vessel normalization enhances immunotherapy in resistant tumors

    Ganss and colleagues show that targeting the inflammatory cytokine LIGHT to tumor vessels via a vascular targeting peptide induces tertiary lymphoid structures and enables the influx of endogenous T cells and ...

    Anna Johansson-Percival, Bo He, Zhi-Jie Li, Alva Kjellén in Nature Immunology (2017)

  18. No Access

    Article

    Improved microwave absorption properties of core–shell type Ni@SiC nanocomposites

    SiC coated Ni nanocomposites were fabricated by a facile arc-discharge method. XRD, HRTEM and XPS technologies indicate that as-prepared Ni@SiC nanocomposites consist of the Ni nanoparticles core and shells co...

    Zhi-Jie Li, Gui-Mei Shi in Journal of Materials Science: Materials in Electronics (2017)

  19. No Access

    Article

    An unusual Lophodermium species on needles of Pinus taiwanensis from China

    An interesting fungus, which appeared to resemble a contaminated or infected Lophodermium species, is described and illustrated in this paper. The circinate apex of paraphyses, which intertwined with each other, ...

    Zhi-Jie Li, J. E. Taylor, Cheng-Lin Hou in Mycological Progress (2016)

  20. Article

    Open Access

    Vascular-targeted TNFα and IFNγ inhibits orthotopic colorectal tumor growth

    Tumor necrosis factor alpha (TNFα) and interferon gamma (IFNγ) were originally identified to show potent anti-tumor activity and immunomodulatory capability. Unfortunately, several clinical studies of relevant...

    **g Shen, Zhi Jie Li, Long Fei Li, Lan Lu in Journal of Translational Medicine (2016)

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