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Article
Open AccessReciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry
Induced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial mitotic proteins for degradation. ...
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Chapter and Conference Paper
Research on Elastic Wave Reverse Time Migration Method for Single Component Data
The seismic waves propagating in actual earth media include longitudinal and transverse waves, which are coupled together and have vector characteristics of multi-wave and multi-component. At present, land sei...
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Article
Translation and validation of a Chinese version of the pancreatitis quality of life instrument (PANQOLI) in patients with chronic pancreatitis
Chronic pancreatitis (CP) is a chronic fibroinflammatory pancreatic disease that severely impacts patients’ quality of life (QoL). The Pancreatitis Quality of Life Instrument (PANQOLI) is an 18-item measure sp...
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Article
Single-cell RNA sequencing deciphers the mechanism of sepsis-induced liver injury and the therapeutic effects of artesunate
Liver, as an immune and detoxification organ, represents an important line of defense against bacteria and infection and a vulnerable organ that is easily injured during sepsis. Artesunate (ART) is an anti-mal...
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Article
Open AccessStatus quo of the public’s knowledge of probiotics based on video-sharing platforms
Probiotics have been deemed multipotent and unprecedentedly applied in the health field recently. However, there are challenges in promoting credible and reliable resources while avoiding misinformation regard...
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Article
Open AccessIdentification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA
Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in develo** countries. In the history of anti-malaria campaign, chloroquine (CQ) has played an indi...
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Article
Open AccessCelastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol (Cel) is a natural anti-inflamm...
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Article
Sparing lung tissue with virtual block method in VMAT planning for locally advanced non-small cell lung cancer
This study aimed to exploit a new virtual block method to spare normal lung tissue in VMAT planning for patients with locally advanced non-small cell lung cancer (LA-NSCLC). The previous method was used to man...
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Article
A refined analysis for the transversely isotropic plate under normal loads with the 3D Green’s function
Many composite plates behave transversely isotropic. An accurate and efficient 3D analysis for the transversely isotropic plate will contribute much to the accurate design and quality promotion of this kind of...
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Article
Numerical simulation study on monoblock casting process of ultra-slender structural components and experimental validation
Substrate, a typical ultra-slender aluminum alloy structural components with a large aspect ratio and complex internal structure, was traditionally manufactured by re-assembly and sub-welding. In order to real...
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Chapter
Typical Cases of Chronic Pancreatitis
Six cases with various clinical manifestations and treatments are presented in this chapter.
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Article
2D steady-state general solution and fundamental solution for fluid-saturated, orthotropic, poroelastic materials
The 2D steady-state solutions regarding the expressions of stress and strain for fluid-saturated, orthotropic, poroelastic plane are derived in this paper. For this object, the general solutions of the corresp...
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Article
Improving the ring-opening polymerization of ε-caprolactone and l-lactide using stannous octanoate
A series of ligands were tested to meliorate the catalytic activity of ε-caprolactone (CL) and l-lactide (LA) polymerization by Sn(Oct)2 and BnOH. There are seven ligands (methyl 2-(dibenzylamino)acetate (MDBAA),...
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Article
TGF-β induces apoptosis through Smad-mediated expression of DAP-kinase
Transforming growth factor-β (TGF-β) and TGF-β-related factors induce apoptosis in a variety of tissues; however, the mechanism underlying this induction is largely unknown. Here, we demonstrate that TGF-β ind...
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Article
Synthesis of Methyl tert-Butyl Ether from tert-Butyl Alcohol and Methanol Using Beta Zeolite Catalysts
MTBE synthesis from tert-butyl alcohol (t-BA) and methanol has been studied using beta zeolites. Increasing the reaction temperature results in an increase of t-BA conversion with concomittant decrease of MTBE se...
