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5,339 Result(s)
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Article
Open AccessGenetic diversity and prevalence of emerging Rickettsiales in Yunnan Province: a large-scale study
Rickettsia and related diseases have been identified as significant global public health threats. This study involved comprehensive field and systematic investigations of various rickettsial organisms in Yunna...
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A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and pathogenicity. Given the emergence of increasingly drug-resistant str...
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Article
Dysregulated Wnt/β-catenin signaling confers resistance to cuproptosis in cancer cells
Cuproptosis is characterized by the aggregation of lipoylated enzymes of the tricarboxylic acid cycle and subsequent loss of iron-sulfur cluster proteins as a unique copper-dependent form of regulated cell dea...
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Open AccessPopulation structure and selection signal analysis of indigenous sheep from the southern edge of the Taklamakan Desert
Analyzing the genetic diversity and selection characteristics of sheep (Ovis aries) holds significant value in understanding their environmental adaptability, enhancing breeding efficiency, and achieving effec...
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Upcycling waste sewage sludge into superior single-atom Fenton-like catalyst for sustainable water purification
The worldwide generation of waste sludge emanating from municipal wastewater treatment plants amounts to 80–90 million tons of dry matter annually and continues to escalate, posing a substantial economic and e...
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Article
Quantum phase transition and entanglement entropy in the Dicke model with a squeezed light
Superradiant phase transition and entanglement entropy in the Dicke model with a squeezed light are investigated. We find a special rotation coordinate system map** the original Hamiltonian into an effective...
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Article
Energy partition in laser-induced cavitation bubbles near the rigid wall with a gas-containing hole
To investigate the energy partition in laser-induced cavitation bubbles near the rigid wall with a gas-containing hole, we utilized a nanosecond resolution photography system based on a Q-switched Nd: YAG lase...
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Open AccessArtificial sweeteners and risk of incident cardiovascular disease and mortality: evidence from UK Biobank
Artificial sweeteners are widely popular worldwide as substitutes for sugar or caloric sweeteners, but there are still several important unknowns and controversies regarding their associations with cardiovascu...
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Open AccessAggravating effect of abnormal low-density protein cholesterol level on coronary atherosclerotic plaque in type 2 diabetes mellitus patients assessed by coronary computed tomography angiography
The abnormal low-density protein cholesterol (LDL-C) level in the development of atherosclerosis is often comorbid in individuals with type 2 diabetes mellitus(T2DM). This study aimed to investigate the aggrav...
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Article
High-performance 1D CsPbBr3/CdS photodetectors
The emergence of all-inorganic perovskite CsPbBr3 has ignited significant interest in optoelectronic devices, However, CsPbBr3 thin film-based photodetectors face performance limitations due to grain boundaries a...
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Article
Effect of graphene addition on activation and kinetic properties of La–Mg–Ni-based hydrogen storage alloys
The La1.7Pr0.3Mg16Ni hydrogen storage alloy was prepared by medium-frequency induction melting, and then the composite hydrogen storage alloy powder of La1.7Pr0.3Mg16Ni + x wt.% (x = 0, 2, 4, and 6) graphene was ...
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Article
Open AccessMyricetin mitigates motor disturbance and decreases neuronal ferroptosis in a rat model of Parkinson’s disease
Ferroptosis is an iron-dependent cell death form characterized by reactive oxygen species (ROS) overgeneration and lipid peroxidation. Myricetin, a flavonoid that exists in numerous plants, exhibits potent ant...
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Article
Epidermal visualized health monitoring system based on stretchable and washable TPU hybrid conductive microtextiles
Electronic textiles, an emerging class of electronic technology, offer exciting opportunities for seamless integration with the human body. Numerous applications have been developed based on electronic textile...
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Article
The marine-derived compound TAG alleviates Parkinson’s disease by restoring RUBCN-mediated lipid metabolism homeostasis
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and its prevalence is increasing. Currently, no effective therapies for PD exist. Marine-derived natural compounds are considered i...
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Iron oxide/CNT-based artificial nacre for electromagnetic interference shielding
Biological structural materials, despite consisting of limited kinds of compounds, display multifunctionalities due to their complex hierarchical architectures. While some biomimetic strategies have been appli...
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Article
Bitter taste TAS2R14 activation by intracellular tastants and cholesterol
Bitter taste receptors, particularly TAS2R14, play central roles in discerning a wide array of bitter substances, ranging from dietary components to pharmaceutical agents1,2. TAS2R14 is also widely expressed in e...
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Article
The impact of gender on survival outcomes in patients with small intestinal stromal tumors: a comprehensive analysis using the SEER database
Small intestinal stromal tumors (SISTs) are a rare type of mesenchymal tumor. Gender is known to influence the incidence and prognosis of various tumors, but its role on the survival of SISTs at the population...
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Open AccessNotoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling
Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased intestinal permeability. Current treatments of IBD primarily ad...
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Open AccessNonlinear association between atherogenic index of plasma and type 2 diabetes mellitus in overweight and obesity patients: evidence from Chinese medical examination data
The atherogenic index of plasma (AIP) is closely associated with the onset of diabetes, with obesity being a significant risk factor for type 2 diabetes mellitus (T2DM). However, the association between the AI...
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Open AccessMRI radiomics enhances radiologists’ ability for characterizing intestinal fibrosis in patients with Crohn’s disease
We aimed to develop MRI-based radiomic models (RMs) to improve the diagnostic accuracy of radiologists in characterizing intestinal fibrosis in patients with Crohn’s disease (CD).