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Article
Open AccesseIF6 Promotes Gastric Cancer Proliferation and Invasion by Regulating Cell Cycle
To investigate the role and function of eIF6 in gastric cancer (GC).
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Article
Open AccessAggravating effect of abnormal low-density protein cholesterol level on coronary atherosclerotic plaque in type 2 diabetes mellitus patients assessed by coronary computed tomography angiography
The abnormal low-density protein cholesterol (LDL-C) level in the development of atherosclerosis is often comorbid in individuals with type 2 diabetes mellitus(T2DM). This study aimed to investigate the aggrav...
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Article
Open AccessAssessment of subclinical LV myocardial dysfunction in T2DM patients with diabetic peripheral neuropathy: a cardiovascular magnetic resonance study
Diabetic peripheral neuropathy (DPN) is the most prevalent complication of diabetes, and has been demonstrated to be independently associated with cardiovascular events and mortality. This aim of this study wa...
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Article
Open AccessAdditive effect of admission hyperglycemia on left ventricular stiffness in patients following acute myocardial infarction verified by CMR tissue tracking
Stress hyperglycemia occurs frequently in patients following acute myocardial infarction (AMI) and may aggravate myocardial stiffness, but relevant evidence is still lacking. Accordingly, this study aimed to e...
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Article
Open AccessOliTag-seq enhances in cellulo detection of CRISPR-Cas9 off-targets
The potential for off-target mutations is a critical concern for the therapeutic application of CRISPR-Cas9 gene editing. Current detection methodologies, such as GUIDE-seq, exhibit limitations in oligonucleot...
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Article
Open AccessEnantioselective synthesis of chiral amides by carbene insertion into amide N–H bond
Chiral amides are important structure in many natural products and pharmaceuticals, yet their efficient synthesis from simple amide feedstock remains challenge due to its weak Lewis basicity. Herein, we descri...
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Article
Effect of distance between heat sources on droplet transfer behavior and weld formation of AH36 during laser and CWW GMAW arc hybrid welding
In order to analyze the influence of the distance between heat sources (DLA) on the welding process, the effects of DLA on the droplet transfer behavior, weld formation characteristics and weld formation mechanis...
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Article
Multiphase evolution of a Li-pegmatite field from the Tashisayi area, Altyn Tagh, NW China: insights from a petrological, geochemical, and geochronological study
The Tashisayi Li deposit was newly discovered in the eastern part of the Tashisayi batholith, located in the Altyn Tagh region of Northwest China. A Li-rich composite pegmatite-aplite dyke (γ02) displays super...
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Article
Open AccessThe optimal threshold of PD-L1 combined positive score to predict the benefit of PD-1 antibody plus chemotherapy for patients with HER2-negative gastric adenocarcinoma: a meta-analysis
Immune checkpoint inhibitors (ICIs) combined with chemotherapy have become the first-line treatment of metastatic gastric and gastroesophageal adenocarcinomas (GEACs). This study aims to figure out the optimal...
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Article
Open AccessNLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis
Members of the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) family regulate various physiological and pathological processes. However, none have been shown ...
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Article
Secondary Metabolites of Chaetomium angustispirale
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Article
Open AccessGlycemic control and clinical outcomes in diabetic patients with heart failure and reduced ejection fraction: insight from ventricular remodeling using cardiac MRI
Glycemic control, as measured by glycosylated hemoglobin (HbA1c), is an important biomarker to evaluate diabetes severity and is believed to be associated with heart failure development. Type 2 diabetes mellit...
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Article
Open AccessThe additive effect of metabolic syndrome on left ventricular impairment in patients with obstructive coronary artery disease assessed by 3.0 T cardiac magnetic resonance feature tracking
Metabolic syndrome (MetS) can increase the risk of morbidity and mortality of cardiovascular disease and obstructive coronary artery disease (OCAD), which usually have a poor prognosis. This study aimed to exp...
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Article
Open AccessOsteoarthritis and hypertension: observational and Mendelian randomization analyses
The association between osteoarthritis (OA) and hypertension is a subject of ongoing debate in observational research, and the underlying causal relationship between them remains elusive.
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Article
Open AccessFast pseudorandom quantum state generators via inflationary quantum gates
We propose a mechanism for reaching pseudorandom quantum states, computationally indistinguishable from Haar random, with shallow log-n depth quantum circuits, where n is the number of qudits. We argue that ...
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Article
Optimization Design of the Multi-Layer Cross-Sectional Layout of An Umbilical Based on the GA-GLM
Marine umbilical is one of the key equipment for subsea oil and gas exploitation, which is usually integrated by a great number of different functional components with multi-layers. The layout of these compone...
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Article
Notably Accelerated Nano-Bainite Transformation via Increasing Undissolved Carbides Content on GCr15Si1Mo Bearing Steel
In this study, a high-carbon nano-bainitic GCr15Si1Mo bearing steel was investigated. Specifically, the effects of content and size of undissolved carbides on the microstructure and transformation kinetics of ...
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Article
Open AccessTargeting P2Y14R protects against necroptosis of intestinal epithelial cells through PKA/CREB/RIPK1 axis in ulcerative colitis
Purinergic signaling plays a causal role in the pathogenesis of inflammatory bowel disease. Among purinoceptors, only P2Y14R is positively correlated with inflammatory score in mucosal biopsies of ulcerative coli...
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Article
Open AccessThe worsening effect of paroxysmal atrial fibrillation on left ventricular function and deformation in type 2 diabetes mellitus patients: a 3.0 T cardiovascular magnetic resonance feature tracking study
Atrial fibrillation (AF) has been linked to an increased risk of cardiovascular death, overall mortality and heart failure in patients with type 2 diabetes mellitus (T2DM). The present study investigated the a...
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Article
Flotation separation of feldspar from quartz using sodium fluosilicate as a selective depressant
The physical and chemical properties of feldspar and quartz are highly similar, thus they cannot be easily separated effectively. In this work, the flotation separation of feldspar from quartz using sodium flu...
