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Article

Targeting P2Y₁₄R protects against necroptosis of intestinal epithelial cells through PKA/CREB/RIPK1 axis in ulcerative colitis

Purinergic signaling plays a causal role in the pathogenesis of inflammatory bowel disease. Among purinoceptors, only P2Y₁₄R is positively correlated with inflammatory score in mucosal biopsies of ulcerative coli...

Chunxiao Liu, Hui Wang, Lu Han, Yifan Zhu, Shurui Ni, **gke Zhi… in Nature Communications (2024)