-
Article
Open AccessThe development of a novel zeolite-based assay for efficient and deep plasma proteomic profiling
Plasma proteins are considered the most informative source of biomarkers for disease diagnosis and monitoring. Mass spectrometry (MS)-based proteomics has been applied to identify biomarkers in plasma, but the...
-
Article
Open AccessMagmatic-hydrothermal fluid evolution of the tin-polymetallic metallogenic systems from the Weilasituo ore district, Northeast China
The large Weilasituo Sn-polymetallic deposit is a recent exploration discovery in the southern Great **ng’an Range, northeast China. The ore cluster area shows horizontal mineralization zoning, from the inner ...
-
Article
Research on accelerating the corrosion of 7B04 aluminium alloy in the Lacticaseibacillus paracasei environment
Microbially influenced corrosion is one of the main issues of concern in industries due to its significant economic impact. In this work, we focused on Lacticaseibacillus paracasei, a typical microorganism identi...
-
Article
The role of mantle melting in granite-associated hydrothermal systems: He–Ar isotopes in fluids responsible for Sn–Ag–Pb–Zn mineralization in northeast China
The relationship between Sn–Ag mineralization and mantle magmatism is a topic of high interest in current ore deposit research. Here, we investigate porphyry-, skarn-, and cassiterite-sulfide type Sn-polymetal...
-
Article
Nonlinear decay behavior of small strain dynamic shear modulus of lime-treated expansive soil
Expansive soil is a kind of problematic soil with poor engineering properties, and it needs to be treated before reusing it as engineering construction material. The soil under dynamic load in engineering ofte...
-
Article
Failure Evolution Characteristics and Resistivity Damage Model of Expansive Clay with Filled Fissures under Uniaxial Compression
The fissure in expansive soil is an important factor to control the failure and stability of expansive soil foundation, slope, and underground engineering. This study utilizes the uniaxial compression–resistiv...
-
Article
Open AccessHuman umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT/GSK-3β/β-TrCP/Nrf2 axis
Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) engraftment is a promising therapy for acute ischemic stroke (AIS). However, the harsh ischemic microenvironment limits the therapeutic efficacy of ...
-
Article
Open AccessDown-regulation of PBK inhibits proliferation of human endometrial stromal cells in thin endometrium
Thin endometrium (TE) is a challenging clinical issue in the reproductive medicine characterized by inadequate endometrial thickness, poor response to estrogen and no effective treatments currently. At present...
-
Article
Open AccessAuthor Correction: Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
-
Article
An efficient multi-objective optimization method based on the adaptive approximation model of the radial basis function
Considering the high computational cost caused by solving multi-objective optimization (MOO) problems, an efficient multi-objective optimization method based on the adaptive approximation model is developed. F...
-
Article
Open AccessTGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats
Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) plays an important role in mediating inflammatory responses during ischemic stroke. Bile acid receptor Takeda-G...
-
Article
Mineralogical Characteristics and in-situ Sulfur Isotopic Analysis of Gold-Bearing Sulfides from the Qilishan Gold Deposit in the Jiaodong Peninsula, China
Large-scale gold mineralization during the Early Cretaceous is identified in the Jiaodong Peninsula of China. Sources of ore-forming fluids remain debated. We study the Qilishan gold deposit in the northwester...
-
Article
Open AccessSingle-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic osteosarcoma lesions, 11 major ce...
-
Article
An Energy Efficient Clustering Algorithm Based on Annulus Division Applied in Wireless Sensor Networks
Energy efficiency and energy balance are two important performance indexes in wireless sensor networks which determine the lifetime of networks. This paper proposes a protocol, termed as annulus division based...
-
Article
Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation
Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC), which has a male predominance, lacks effective therapeutic options. Previously, the cardiac glycoside analogue bufalin has been found to inhib...
-
Article
An improved calculation model for predicting the coefficient of restitution and maximum impact force of rockfalls
Rockfalls, which are a common natural hazard, collide and continuously bounce along slope surfaces during their movement; the coefficient of restitution (COR) and impact force are two important characteristic ...
-
Article
Open AccessAdenosine A2A Receptors in Bone Marrow-Derived Cells Attenuate Cognitive Impairment in Mice After Chronic Hypoperfusion White Matter Injury
The mechanism of cognitive dysfunction caused by ischemic white matter lesions is unclear. To explore the effect and mechanism of different cell-derived adenosine A2A receptor (A2AR) in cognitive impairment cause...
-
Article
Open AccessDoped holographic fermionic system
We construct a two-current model. It includes two gauge fields, which introduce the do** effect, and a neutral scalar field. And then we numerically construct an AdS black brane geometry with scalar hair. Ov...
-
Article
Open AccessΔNp63α-induced DUSP4/GSK3β/SNAI1 pathway in epithelial cells drives endometrial fibrosis
Epithelial homeostasis plays an essential role in maintaining endometrial function. But the epithelial role in endometrial fibrosis has been less studied. Previously, we showed that ectopic expression of ΔNp63...
-
Article
Cue–target onset asynchrony modulates interaction between exogenous attention and audiovisual integration
Previous studies have shown that exogenous attention decreases audiovisual integration (AVI); however, whether the interaction between exogenous attention and AVI is influenced by cue–target onset asynchrony (...
