5,259 Result(s)
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Zhen-** Zhang
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Article
Open AccessNon-Abelian braiding of Fibonacci anyons with a superconducting processor
Quantum many-body systems with a non-Abelian topological order can host anyonic quasiparticles. It has been proposed that anyons could be used to encode and manipulate information in a topologically protected ...
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Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction
Cardiac fibrosis is a pathological scarring process that impairs cardiac function. N-acetyltransferase 10 (Nat10) is recently identified as the key enzyme for the N4-acetylcytidine (ac4C) modification of mRNAs...
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Efficacy and Safety of Bufei Jiedu Granules in Treating Multidrug-Resistant Pulmonary Tuberculosis: A Multi-center, Double-Blinded and Randomized Controlled Trial
To assess the efficacy and safety of Bufei Jiedu (BFJD) ranules as adjuvant therapy for patients with multidrug-resistant pulmonary tuberculosis (MDR-PTB).
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Absence of ultrasonic-vibration-induced plasticity in metallic glacial glasses
Metallic glasses (MGs) have been found to exhibit unexpected ultrasonic-vibration-induced plasticity (UVIP), which provides a promising way to realize room temperature processing and molding of MGs. However, w...
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Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Open AccessPerformance improvements in complementary metal oxide semiconductor devices and circuits based on fin field-effect transistors using 3-nm ferroelectric Hf0.5Zr0.5O2
In this work, a conventional HfO2 gate dielectric layer is replaced with a 3-nm ferroelectric (Fe) HZO layer in the gate stacks of advanced fin field-effect transistors (FinFETs). Fe-induced characteristics, e.g....
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Liquiritin inhibits TGF-β1-induced epithelial mesenchymal transition and extracellular matrix deposition in human renal proximal tubular epithelial cells by suppressing the MAPK signaling
Excessive extracellular matrix (ECM) deposition leads to renal fibrosis, a typical hallmark of chronic kidney disease. Liquiritin is a flavonoid extracted from the rhizome part of Glycyrrhiza glabra and has an...
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A Variance-Based Sensitivity Analysis Approach for Identifying Interactive Exposures
Chemical mixtures can significantly affect human health, but understanding the interactions among various chemical exposures and identifying influential ones in relation to some health outcomes are difficult. ...
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Article
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway
Refractory wounds are a severe complication of diabetes mellitus that often leads to amputation because of the lack of effective treatments and therapeutic targets. The pathogenesis of refractory wounds is com...
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A deep learning model for translating CT to ventilation imaging: analysis of accuracy and impact on functional avoidance radiotherapy planning
Radiotherapy planning incorporating functional lung images has the potential to reduce pulmonary toxicity. Free-breathing 4DCT-derived ventilation image (CTVI) may help quantify lung function. This study intro...
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Abnormal phosphorylation / dephosphorylation and Ca2+ dysfunction in heart failure
Heart failure (HF) can be caused by a variety of causes characterized by abnormal myocardial systole and diastole. Ca2+ current through the L-type calcium channel (LTCC) on the membrane is the initial trigger sig...
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Open AccessTranscriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity
Aging and obesity pose significant threats to public health and are major contributors to muscle atrophy. The trends in muscle fiber types under these conditions and the transcriptional differences between dif...
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miR-338-5p regulated the NF-κB/MAPK pathway to alleviate inflammation and oxidative stress by targeting IL-6 in rats with atrial fibrillation
The aim of this study was to investigate the functional effect of miR-338-5p targeting IL-6 on NF-κB/MAPK pathway-mediated inflammation and oxidative stress in atrial fibrillation (AF) rats. AF model rats were...
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Open AccessA broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug
SARS-CoV-2 infection is initiated by Spike glycoprotein binding to the human angiotensin-converting enzyme 2 (ACE2) receptor via its receptor binding domain. Blocking this interaction has been proven to be an ...
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Open AccessDuck STING mediates antiviral autophagy directing the interferon signaling pathway to inhibit duck plague virus infection
Migratory birds are important vectors for virus transmission, how migratory birds recognize viruses and viruses are sustained in birds is still enigmatic. As an animal model for waterfowl among migratory birds...
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Coupling effect of freezing-thawing cycles and dynamic loading on the accumulative deformation and microstructure of foam concrete
Foam concrete is characterized by lightweight, self-compacting and high flowability, thereby widely used as a subgrade bed filler. High-speed railway subgrades usually experience inhomogeneous deformation due ...
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Open AccessNicotinate-curcumin improves NASH by inhibiting the AKR1B10/ACCα-mediated triglyceride synthesis
Nonalcoholic steatohepatitis (NASH) is a prevalent chronic liver condition. However, the potential therapeutic benefits and underlying mechanism of nicotinate-curcumin (NC) in the treatment of NASH remain unce...
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Open AccessDevelopment of a Pt(II) compound based on indocyanine green@human serum albumin nanoparticles: integrating phototherapy, chemotherapy and immunotherapy to overcome tumor cisplatin resistance
Cisplatin resistance is the main cause for the failure of cancer therapy. To solve the problem, we proposed to develop a novel human serum albumin (HSA) nanoplatform to integrate chemotherapy, photothermal the...
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Ensemble successor representations for task generalization in offline-to-online reinforcement learning
In reinforcement learning (RL), training a policy from scratch with online experiences can be inefficient because of the difficulties in exploration. Recently, offline RL provides a promising solution by givin...
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Article
Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06
Two new aromatic tenvermectins (TVMs), 13-oleandrosyl-oleandrosyloxy ST906 (1) and aromatic TVM B (2), were isolated from the fermentation broth of Streptomyces avermitilis HU02-06. Their structures were establis...
