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Article
Open AccessZinc Deficiency as a General Feature of Cancer: a Review of the Literature
Trace elements are minerals that are present in very low concentrations in the human body and yet are crucial for a wide range of physiological functions. Zinc, the second most abundant trace element, is obtai...
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Article
Open AccessDemographic and clinical characteristics of patients with zinc deficiency: analysis of a nationwide Japanese medical claims database
Zinc deficiency, affecting more than 2 billion people globally, poses a significant public health burden due to its numerous unfavorable effects, such as impaired immune function, taste and smell disorders, pn...
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Article
Open AccessObservation of Bose-Einstein condensates of excitons in a bulk semiconductor
An unambiguous observation of the Bose-Einstein condensation (BEC) of excitons in a photoexcited bulk semiconductor and elucidation of its inherent nature have been longstanding problems in condensed matter ph...
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Article
Open AccessAssociation between induction of the self-management system for preventing readmission and disease severity and length of readmission in patients with heart failure
We recently developed the self-management system using the HF points and instructions to visit hospitals or clinics when the points exceed the pre-specified levels. We found that the self-management system dec...
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Article
A case of granulocyte colony-stimulating factor-producing intrahepatic sarcomatoid cholangiocarcinoma
Here, we report a rare case of intrahepatic sarcomatoid cholangiocarcinoma that expressed granulocyte colony-stimulating factor (G-CSF). An 87-year-old man who presented with a continuous high-grade fever and ...
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Article
Clinical effectiveness and adverse events associated with tolvaptan in patients above 90 years of age with acute decompensated heart failure
With the aging society, the number of very-elderly (VE) patients with acute decompensated heart failure (ADHF) is increasing. Although tolvaptan is recommended for patients with ADHF in whom conventional diure...
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Article
Cor triatriatum dexter associated with atrial septal defect and mitral valve regurgitation
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Article
Clinical characteristics and outcomes of patients with venous thromboembolism according to diagnosis on weekends versus on weekdays
There are uncertainties on the influence of the days of diagnosis in a week (weekends versus weekdays) on clinical outcomes in patients with acute venous thromboembolism (VTE), including pulmonary embolism (PE...
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Article
Multiplicity Adjustment and Sample Size Calculation in Clinical Trials with Multiple Endpoints: An Industry Survey of Current Practices in Japan
Two issues in clinical trials with multiple endpoints were surveyed: (1) the terminology of multiple endpoints, the relationship between rare events and endpoints, and the differences in multiplicity adjustmen...
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Article
Association with left atrial volume index and long-term prognosis in patients without systolic dysfunction nor atrial fibrillation: an observational study
The prognostic impact of left atrial size in patients without systolic dysfunction nor atrial fibrillation (AF) has not been fully elucidated in Japan. We retrospectively analyzed data obtained from 4444 conse...
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Article
Oviposition inhibitor in umbelliferous medicinal plants for the common yellow swallowtail (Papilio machaon)
Umbelliferous medicinal plants, such as Angelica acutiloba Kitagawa and Angelica dahurica Bentham et Hooker filius ex Franchet et Savatier, account for a large percentage of crude drug consumption in Japan. The m...
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Chapter
Digital Reconstruction of Neanderthal and Early Homo sapiens Endocasts
Endocranial morphology is currently the most useful source of information available for estimating the brain morphology and, hence, possible differences in cognitive ability in fossil hominins. Recently, compu...
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Article
Open AccessGenome-wide profiling of nardilysin target genes reveals its role in epigenetic regulation and cell cycle progression
Post-translational histone modifications, such as acetylation and methylation, are prerequisites for transcriptional regulation. The metalloendopeptidase nardilysin (Nrdc) is a H3K4me2-binding protein that con...
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Article
A case of cutaneous polyarteritis nodosa with PR3-ANCA
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Chapter and Conference Paper
An Analysis of Students’ Learning Behaviors Using Variable-Speed Playback Functionality on Online Educational Platforms
The goal of this study is to clarify how students’ learning styles give effects to their learning experience and behaviors while visual contents presented at high speed. In our experiment, participants (10 vis...
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Chapter and Conference Paper
Learning by Tangible Learning System in Science Class
Tangible User Interfaces are one of the ideas to develop a learning materials as an invisible computing system. First, we developed a tangible learning system for learning Solar System that allows the users th...
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Article
Current Practice on Multiplicity Adjustment and Sample Size Calculation in Multi-arm Clinical Trials: An Industry Survey in Japan
This study provides the results of a survey on the current practice of multiplicity adjustment and sample size calculation in multi-arm clinical trials.
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Article
Comparative analysis of the constituents in Saposhnikoviae Radix and Glehniae Radix cum Rhizoma by monitoring inhibitory activity of nitric oxide production
During the development of natural herbal medicines in Japan, Glehniae Radix cum Rhizoma (Hamabofu in Japanese) has been used as a substitute for Saposhnikoviae Radix (Bofu). Bofu and Hamabofu are blended diffe...
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Article
Non-solar-induced elastotic bands on the forearm
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Chapter
A Geometric Morphometric Study of Neurocranial Shape Variations in the Crania of Modern Japanese
We analyzed the morphological variability of the cranial shape among the modern Japanese population using landmark-based geometric morphometrics. The sample comprised 56 cranial specimens of the modern Japanes...
