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Article
Open AccessThromboxane prostanoid signaling in macrophages attenuates lymphedema and facilitates lymphangiogenesis in mice
Accumulating evidence suggests that prostaglandin E2, an arachidonic acid (AA) metabolite, enhances lymphangiogenesis in response to inflammation. However, thromboxane A2 (TXA2), another AA metabolite, is not wel...
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Article
Open AccessMorphological differences in the calcaneus among extant great apes investigated by three-dimensional geometric morphometrics
Investigating the morphological differences of the calcaneus in humans and great apes is crucial for reconstructing locomotor repertories of fossil hominins. However, morphological variations in the calcaneus ...
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Article
Open AccessVEGFR1-tyrosine kinase signaling in pulmonary fibrosis
Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3. Idiopathic pulm...
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Article
Open AccessVEGF Receptor 1-Expressing Macrophages Recruited from Bone Marrow Enhances Angiogenesis in Endometrial Tissues
Angiogenesis is critical in maintenance of endometrial tissues. Here, we examined the role of VEGF receptor 1 (VEGFR1) signaling in angiogenesis and tissue growth in an endometriosis model. Endometrial fragmen...
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Article
Vascular endothelial growth factor receptor 1 (VEGFR1) tyrosine kinase signaling facilitates granulation tissue formation with recruitment of VEGFR1+ cells from bone marrow
Vascular endothelial growth factor (VEGF)-A facilitates wound healing. VEGF-A binds to VEGF receptor 1 (VEGFR1) and VEGFR2 and induces wound healing through the receptor’s tyrosine kinase (TK) domain. During b...
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Article
Open AccessReconstructing the Neanderthal brain using computational anatomy
The present study attempted to reconstruct 3D brain shape of Neanderthals and early Homo sapiens based on computational neuroanatomy. We found that early Homo sapiens had relatively larger cerebellar hemispheres ...
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Chapter
Digital Reconstruction of Neanderthal and Early Homo sapiens Endocasts
Endocranial morphology is currently the most useful source of information available for estimating the brain morphology and, hence, possible differences in cognitive ability in fossil hominins. Recently, compu...
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Chapter
The Evolution of the Parietal Lobes in the Genus Homo
The parietal areas have always been of major interest in paleoneurology because of their remarkable variation among hominids. In neuroanatomy, difficulties in defining their blurred boundaries and their comple...
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Article
Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the upregulation of epidermal growth factor expression on VEGFR1+CXCR4+ cells recruited from bone marrow
Angiogenesis is essential for gastric ulcer healing. Recent results suggest that vascular endothelial growth factor receptor 1 (VEGFR1), which binds to VEGF, promotes angiogenesis. In the present study, we in...
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Chapter
A Geometric Morphometric Study of Neurocranial Shape Variations in the Crania of Modern Japanese
We analyzed the morphological variability of the cranial shape among the modern Japanese population using landmark-based geometric morphometrics. The sample comprised 56 cranial specimens of the modern Japanes...
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Chapter
Application of Sliding Landmark Method for Morphological Analysis of Modern Japanese Neurocranial Shape
We apply the sliding semi-landmark method for the analysis of morphological variability in the modern Japanese population. Specifically, we prepare two kinds of template landmark configurations that will be pr...
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Chapter
Statistical Interpolation of Missing Parts in Human Crania Using Regularized Multivariate Linear Regression Analysis
Anatomically-accurate interpolation of missing parts in fossil crania is important for correct estimation of brain morphology based on cranial shape information. In the present study, we attempted to establish...
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Article
Open AccessThymic large cell neuroendocrine carcinoma: report of a resected case - a case report
Thymic large cell neuroendocrine carcinomas (LCNECs) are very rare. We here describe a case in which the tumor could be completely resected. A 55-year-old male was admitted to our hospital for treatment of an ...
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Article
Clinical report on a computer-controlled hand-actuated stapling system for general lung surgery: the first application in Japan
Computer-controlled stapling systems can improve lung tissue approximation during thoracic surgery. We report our experience with a handy system with computer-controlled placement of staples for lung resection...
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Article
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes
The mechanisms through which hematopoietic cytokines accelerate revascularization are unknown. Here, we show that the magnitude of cytokine-mediated release of SDF-1 from platelets and the recruitment of nonen...
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Article
Cyclooxygenase-2 and adenylate cyclase/protein kinase A signaling pathway enhances angiogenesis through induction of vascular endothelial growth factor in rat sponge implants
Angiogenesis is reportedly enhanced by prostaglandins (PGs). In the present experiment, we tested whether or not COX-2 and adenylate cyclase/protein kinase A (AC/PKA)-dependent VEGF induction enhanced angiogen...
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Article
Costs and benefits for water strider (Aquarius paludum) females of carrying guarding, reproductive males
We describe the mating system of Aquarius paludum insularis based on field observations and test hypotheses about the effects of body size, hunger level and post-copulatory guarding on reproductive performance. T...
