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Article
Open AccessAuxiliary roles of nardilysin in the early diagnosis of acute coronary syndrome: a prospective cohort study, the Nardi-ACS study
Acute coronary syndrome (ACS) includes myocardial infarction (MI) and unstable angina (UA). MI is defined by elevated necrosis markers, preferably high-sensitivity cardiac troponins (hs-cTn). However, it takes...
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Article
Open AccessNardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis
Brown adipose tissue (BAT) dissipates chemical energy as heat through uncoupling protein 1 (UCP1). The induction of mitochondrial reactive oxygen species (ROS) in BAT was recently identified as a mechanism tha...
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Article
Open AccessSerum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke
Acute ischemic stroke (AIS) is a serious cause of mortality and disability. AIS is a serious cause of mortality and disability. Early diagnosis of atherosclerosis, which is the major cause of AIS, allows thera...
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Article
Open AccessGenome-wide profiling of nardilysin target genes reveals its role in epigenetic regulation and cell cycle progression
Post-translational histone modifications, such as acetylation and methylation, are prerequisites for transcriptional regulation. The metalloendopeptidase nardilysin (Nrdc) is a H3K4me2-binding protein that con...
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Article
Open AccessCritical roles of nardilysin in the maintenance of body temperature homoeostasis
Body temperature homoeostasis in mammals is governed centrally through the regulation of shivering and non-shivering thermogenesis and cutaneous vasomotion. Non-shivering thermogenesis in brown adipose tissue ...
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Article
Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system
Nardilysin (NRDc) enhances the shedding of ectodomains from neuronal membrane proteins. The null mutant described here reveals that nardilysin is necessary for myelination in both central and peripheral nervou...
