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Article
Dose–response relationship between arsenic in drinking water and mortality of urinary cancers in Taiwan
Ingested arsenic is carcinogenic to the human urinary tract, but uncertainties remain regarding the dose–response relationship. To assess dose–response relationships between arsenic ingestion and urinary cance...
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Article
Open AccessRisk of diabetes mellitus based on the interactive association between G6PD rs72554664 polymorphism and sex in Taiwan Biobank individuals
The presence of glucose-6-phosphate dehydrogenase (G6PD) deficiency may increase the risk of type 2 diabetes mellitus (T2DM), with differing prevalence between males and females. Although G6PD deficiency is an X-...
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Article
Open AccessMetabolic syndrome risk in adult coffee drinkers with the rs301 variant of the LPL gene
Metabolic syndrome (MetS), a cluster of metabolic and cardiovascular risk factors is influenced by environmental, lifestyle, and genetic factors. We explored whether coffee consumption and the rs301 variant of...
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Article
Open AccessSusceptibility to eye diseases in relation to age and kidney failure among Taiwanese adults
The kidney and eyes share common pathways and are thought to be closely connected. Chronic kidney disease and major eye diseases, such as cataract and glaucoma, are strongly associated with age. However, furth...
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Article
Open AccessThe association between smoking cessation and lifestyle/genetic variant rs6265 among the adult population in Taiwan
Recent studies showed significant associations between socio-demographic, lifestyle factors, polymorphic variant rs6265, and smoking cessation behaviours. We examined rs6265 TT, TC and CC genotypes and their a...
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Article
Risk of gout in Taiwan Biobank participants pertaining to their sex and family history of gout among first-degree relatives
Family history of gout and sex are independently associated with gout. However, there is a paucity of research regarding the joint role of both factors in gout pathogenesis. Therefore, we assessed the independ...
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Article
Spine, hip, and femoral neck bone mineral density in relation to vegetarian type and status among Taiwanese adults
We determined the association of vegetarian type and status with bone mineral density (BMD) Z-scores at the spine, hip, and femoral neck. Compared to non-vegetarians, current vegetarians, especially vegans, lacto...
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Article
Open AccessAssociation between ESR1 rs2234693 single nucleotide polymorphism and uterine fibroids in Taiwanese premenopausal and postmenopausal women
Uterine fibroids (UFs) are uterine smooth muscle neoplasms that affect women, especially during the reproductive stage. Both genetic and lifestyle factors affect the onset of the disease. We examined the assoc...
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Article
Open AccessPublisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries
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Article
Open AccessStroke genetics informs drug discovery and risk prediction across ancestries
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-an...
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Article
Open AccessALDH7A1 rs12514417 polymorphism may increase ischemic stroke risk in alcohol-exposed individuals
Epidemiological studies have identified common risk factors for cerebral stroke worldwide. Some of these factors include hypertension, diabetes, smoking, excessive drinking, and dyslipidemia. It is important t...
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Article
Relationship between Coffee Consumption and Osteoporosis Risk Determined by the ESR1 Polymorphism rs2982573
The development of osteoporosis is partly explained by interactions between genetic and lifestyle or environmental factors.
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Article
Open AccessRisk of uterine leiomyoma based on BET1L rs2280543 single nucleotide polymorphism and vegetarian diet
Bet1 Golgi vesicular membrane trafficking protein-like (BET1L) rs2280543 single nucleotide polymorphism (SNP) and diet have been independently associated with uterine leiomyoma (UL). However, whether the SNP a...
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Article
Open AccessInteraction between a diabetes-related methylation site (TXNIP cg19693031) and variant (GLUT1 rs841853) on fasting blood glucose levels among non-diabetics
Type 2 diabetes mellitus (T2DM) is caused by a combination of environmental, genetic, and epigenetic factors including, fasting blood glucose (FBG), genetic variant rs841853, and cg19693031 methylation. We eva...
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Article
Open AccessRisk of gallstones based on ABCG8 rs11887534 single nucleotide polymorphism among Taiwanese men and women
Gallstones are abnormal masses caused by impaired metabolism of cholesterol, bilirubin, or bile salts in the gallbladder or biliary tract. ATP-binding cassette subfamily G member 8 (ABCG8) is a protein that re...
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Article
Open AccessRisk of HBV infection among male and female first-time blood donors born before and after the July 1986 HBV vaccination program in Taiwan
In July 1984, Taiwan officially began a nationwide hepatitis B virus (HBV) vaccination program where only infants born to HBsAg-positive mothers were vaccinated free of charge until June 1986. However, from Ju...
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Article
Open AccessAssociation between hypertension and coffee drinking based on CYP1A2 rs762551 single nucleotide polymorphism in Taiwanese
Hypertension increases the likelihood of cardiovascular diseases (CVDs). Cytochrome P450 1A2 (CYP1A2) single nucleotide polymorphism (SNP) is related to caffeine metabolism and the risk of CVD among coffee dri...
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Article
Open AccessAssociation of ADH1B polymorphism and alcohol consumption with increased risk of intracerebral hemorrhagic stroke
Alcohol consumption is one of the modifiable risk factors for intracerebral hemorrhage, which accounts for approximately 10–20% of all strokes worldwide. We evaluated the association of stroke with genetic pol...
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Article
Open AccessRisk of gout among Taiwanese adults with ALDH-2 rs671 polymorphism according to BMI and alcohol intake
Gout stems from both modifiable and genetic sources. We evaluated the risk of gout among Taiwanese adults with aldehyde dehydrogenase-2 (ALDH2) rs671 single nucleotide polymorphism (SNP) according to body mass...
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Article
Open AccessInteractive association between dietary fat and sex on CDH13 cg02263260 methylation
DNA methylation of Cadherin 13 (CDH13), a tumor suppressor gene is associated with gene repression and carcinogenesis. We determined the relation of dietary fat and sex with CDH13 cg02263260 methylation in Tai...
