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Article
Accelerating the development of Fe–Co–Ni–Cr system HEAs with high hardness by deep learning based on Bayesian optimization
Machine learning (ML) is progressively supplanting conventional trial-and-error approaches for designing alloys with desirable properties. In this study, four ML regression models were utilized to identify hig...
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Article
Open AccessHOXD10 attenuates renal fibrosis by inhibiting NOX4-induced ferroptosis
In chronic kidney disease (CKD), renal fibrosis is an unavoidable result of various manifestations. However, its pathogenesis is not yet fully understood. Here, we revealed the novel role of Homeobox D10 (HOXD...
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Article
Open AccessGlobal fungal-host interactome map** identifies host targets of candidalysin
Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we perfo...
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Article
Urine-derived stem cell therapy for diabetes mellitus and its complications: progress and challenges
Diabetes mellitus (DM) is a chronic and relentlessly progressive metabolic disease characterized by a relative or absolute deficiency of insulin in the body, leading to increased production of advanced glycosy...
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Article
Rethinking orthographic neighbor in Chinese two-character word recognition: Insights from a megastudy
The influence of orthographic neighbors on visual word recognition is well established in alphabetic scripts. To determine the universality of this effect across writing systems, researchers have been keen on ...
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Article
Vapor–Liquid and Chemical Equilibrium for Esterification of Acetic Acid + Isopropanol with [HSO3-bmim][HSO4] at 101.33 kPa
Vapor–liquid equilibrium data of binary systems (water + acetic acid, isopropanol + water, and acetic acid + isopropyl acetate), and ternary systems (water + acetic acid + 1-sulfobutyl-3-methylimidazolium hydr...
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Article
Fecal antibiotic resistance genes were transferred through the distribution of soil-lettuce-snail food chain
Massive antibiotic resistance genes (ARG) were detected in the soil modified by manure, which may affect human life safety through the food chain. However, the transmission of ARGs through the soil–plant-anima...
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Article
Open AccessSafety of oral propranolol for neonates with problematic infantile hemangioma: a retrospective study in an Asian population
Although the efficacy of propranolol in the treatment of infantile hemangioma (IH) has been well established, clinical data on the safety and tolerability of propranolol in neonates are still lacking. In this ...
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Article
Analysis and optimization of tolerance design for an internal thread grinder
Machining accuracy is an important index for evaluating the performance of machine tools. To improve the machining accuracy and efficiency of an internal thread grinding machine and reduce the cost, this paper...
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Article
Open AccessA nomogram for predicting sclerotherapy response for treatment of lymphatic malformations in children
In this manuscript, we purposed to identify the prognostic factors for treatment of lymphatic malformations in children using polidocanol foam combined with **yangmycin and to construct nomogram for predicti...
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Article
Salinomycin suppresses T24 cells by regulating KDM1A and the unfolded protein response pathway
In recent years, salinomycin has been shown to exert an anticancer effect in a variety of tumors; however, its function and mechanism in bladder cancer (BC) remain unclear. This study examined the effect of sa...
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Article
Open AccessInnate immune responses against the fungal pathogen Candida auris
Candida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial outbreaks worldwide. Although considerable progress has increased our understanding of the biological and clinical aspects o...
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Article
Facial anatomical site-related variation in short-term outcomes of laser treatment for congenital melanocytic nevi
Laser treatment for congenital melanocytic nevi (CMN) is controversial. Correlations between anatomical distribution of facial CMN and efficacy of laser treatment have not been characterized.
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Article
Open AccessDecreased angiotensin receptor 1 expression in ± AT1 Knockout mice testis results in male infertility and GnRH reduction
This study aimed to detect the effect of angiotensin receptor 1 (AT1) knock out (KO) on spermatogenesis and hypothalamic-pituitary–gonadal (HPG) axis hormone expression.
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Article
Open AccessErythema induratum of Bazin as an indicative manifestation of cavitary tuberculosis in an adolescent: a case report
Erythema induratum of Bazin (EIB) is a rare cutaneous manifestation of tuberculosis (TB) that frequently occurs in middle-aged women. The clinical manifestations of EIB can mimic various skin diseases, easily ...
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Article
Open AccessSNP-mediated lncRNA-ENTPD3-AS1 upregulation suppresses renal cell carcinoma via miR-155/HIF-1α signaling
Over the last decade, more than 10 independent SNPs have been discovered to be associated with the risk of renal cell carcinoma among different populations. However, the biological functions of them remain poo...
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Article
Open AccessAssociation between different peritoneal dialysis catheter placement methods and short‐term postoperative complications
Considering that current peritoneal dialysis has its own shortcomings, In this study, the Seldinger technique was modified to explore the relationship between different catheter placement methods of peritoneal...
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Article
PIM1 inhibition attenuated endotoxin-induced acute lung injury through modulating ELK3/ICAM1 axis on pulmonary microvascular endothelial cells
The dysfunction of pulmonary microvascular endothelial cells (PMVECs) is one of the critical characteristics of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) induced by severe infection. PIM...
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Article
Open AccessNovel genetic alteration in congenital melanocytic nevus: MAP2K1 germline mutation with BRAF somatic mutation
Congenital melanocytic nevus (CMN) represent a benign proliferative skin disease in the epidermis and dermis. CMN are historically known to be associated with activating NRAS or BRAF mutations. Melanoma freque...
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Article
Open AccessGiant congenital melanocytic nevus of the scalp: from clinical-histological to molecular diagnosis
Congenital melanocytic nevus (CMN) is a benign proliferative skin disease in the epidermis and dermis. Large to giant CMNs are estimated to be associated with an increased lifetime risk of malignancy. It is ne...
