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Article
Open AccessSystem-wide identification of novel de-ubiquitination targets for USP10 in gastric cancer metastasis through multi-omics screening
Ubiquitin-specific peptidase 10 (USP10), a typical de-ubiquitinase, has been found to play a double-edged role in human cancers. Previously, we reported that the expression of USP10 was negatively correlated w...
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Article
Open AccessImproving access to primary health care through financial innovation in rural China: a quasi-experimental synthetic difference-in-differences approach
Inadequate financing constrains primary healthcare (PHC) capacity in many low- and middle-income countries, particularly in rural areas. This study evaluates an innovative PHC financing reform in rural China t...
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Article
Open AccessNumerical simulation of multi-field coupling in geothermal reservoir heat extraction of enhanced geothermal systems
The coupled analysis of multi-field heat and mass transfer in geothermal reservoirs is a pivotal concern within the realm of geothermal rock exploitation. It holds significant implications for the assessment o...
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Article
Review of 2D Bi2X3 (X = S, Se, Te): from preparation to photodetector
Detector has become an indispensable part of human beings. The increasing demand for photodetectors with high performance has promoted the research of novel materials. At the same time, with the development of...
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Article
Open AccessCentral role of d-band energy level in Cu-based intermetallic alloys
Cu-Au intermetallic alloys are classic paradigms in the history of alloy theory for studying order-disorder transition, phase stability, and so on. However, density functional theory with a generalized gradien...
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Article
Highly efficient 1D p-Te/2D n-Bi2Te3 heterojunction self-driven broadband photodetector
Broadband photodetectors with self-driven functions have attracted intensive scientific interest due to their low energy consumption and high optical gain. However, high-performance broadband self-driven photo...
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Article
Open AccessPropranolol inhibits EMT and metastasis in breast cancer through miR-499-5p-mediated Sox6
This study will focus on 4T1 cells, a murine mammary adenocarcinoma cell line, as the primary research subject. We aim to investigate the inhibitory effects and mechanisms of propranolol on epithelial–mesenchy...
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Article
The formation mechanism of twin type shear bands in β-HMX: molecular rotation and translation
Molecular dynamics simulations are performed to clarify the deformation mechanism of β-HMX crystal in the \({P2}_{1}/n\) ...
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Article
Deep learning-based automated steel surface defect segmentation: a comparative experimental study
The use of machine vision and deep learning for intelligent industrial inspection has become increasingly important in automating the production processes. Despite the fact that machine vision approaches are u...
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Article
Open AccessAssociation between personality characteristics and sleep quality among Chinese middle-aged and older adults: evidence from China family panel studies
Poor sleep quality will have adverse effects on physical and mental health, quality of life and other aspects of middle-aged and older adults. Sleep quality is affected by many factors. Whether the sleep quali...
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Article
Open AccessChronic endometritis incidence in infertile women with and without polycystic ovary syndrome: a propensity score matched study
Polycystic ovary syndrome (PCOS) is known to be associated with chronic low-grade inflammation and endometrial dysfunction. Chronic endometritis (CE) is a type of local inflammation that can contribute to endo...
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Article
Slaking characteristics and rock–mortar interface durability of red-bed mudrock subjected to wet–dry cycles: a case study in the Three Gorges Area, China
The red-bed mudrock of the Middle Triassic Badong Formation in the Three Gorges Area of the Yangtze River is prone to slaking and failure when exposed to wet–dry cycles, resulting in frequent bank collapse in ...
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Article
Open AccessActivation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity
Inhibition of T cell infiltration dampens antitumor immunity and causes resistance to immune checkpoint blockade (ICB) therapy. By in vivo CRISPR screening in B16F10 melanoma in female mice, here we report tha...
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Article
Open AccessGreatly enhanced tunneling electroresistance in ferroelectric tunnel junctions with a double barrier design
We propose that the double barrier effect is expected to enhance the tunneling electroresistance (TER) in the ferroelectric tunnel junctions (FTJs). To demonstrate the feasibility of this mechanism, we design ...
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Article
Open AccessAssociation between malnutrition and stroke-associated pneumonia in patients with ischemic stroke
Malnutrition is associated with a high risk of mortality in adults with ischemic stroke (IS). This study aimed to investigate the relationship between malnutrition and the risk of stroke-associated pneumonia (...
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Article
Behavior and mechanisms of ciprofloxacin adsorption on aged polylactic acid and polyethlene microplastics
Microplastics (MPs) and antibiotics are emerging pollutants in aquatic environments. MPs can absorb antibiotics, resulting in compound pollution. Batch adsorption experiments were used to investigate the adsor...
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Article
Targeted labeling with tissue marking dyes guided by magnifying endoscopy of endoscopic submucosal dissection specimen improves the accuracy of endoscopic and histopathological diagnosis of early gastric cancer: a before–after study
Although histopathological evaluation after endoscopic submucosal dissection (ESD) is critical to assess the accuracy of endoscopic diagnosis, it is still challenging to perform precise endoscopic to pathologi...
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Chapter and Conference Paper
Learning Video Localization on Segment-Level Video Copy Detection with Transformer
At present, research on segment-level video copy detection algorithms mainly focuses on end-to-end optimization from key frame selection and feature extraction to similarity pattern detection, causing the depl...
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Chapter
Shenzhen Jiedian Technology Co., Ltd. v. Shenzhen Laidian Technology Co., Ltd and Anker Innovations Co., Ltd.
When dividing the technical features of the claims, the technical unit that can achieve a relatively independent technical function should generally be treated as a technical feature, and it is inappropriate t...
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Chapter and Conference Paper
Heterogeneous Avatar Synthesis Based on Disentanglement of Topology and Rendering
There are obviously structural and color discrepancies among different heterogeneous domains. In this paper, we explore the challenging heterogeneous avatar synthesis (HAS) task considering topology and render...
