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Article
METTL14/YTHDC1-Mediated m6A Modification in Hippocampus Improves Pentylenetetrazol-Induced Acute Seizures
Epilepsy is a common neurological disorder which can cause significant morbidity and mortality. N6-methyladenosine (m6A), the most common chemical epigenetic modification among mRNA post-transcriptional modifi...
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Article
Open AccessPotential impact of blood cholesterol guidelines on statin treatment in the U.S. population using interrupted time series analysis
The 2013 ACC/AHA Guideline was a paradigm shift in lipid management and identified the four statin-benefit groups. Many have studied the guideline’s potential impact, but few have investigated its potential long-...
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Article
Open AccessSUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1–involved EMT in hepatocellular carcinoma
The protein annexin A6 (AnxA6) is involved in numerous membrane-related biological processes including cell migration and invasion by interacting with other proteins. The dysfunction of AnxA6, including protei...
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Article
Microglia enhance post-anesthesia neuronal activity by shielding inhibitory synapses
Microglia are resident immune cells of the central nervous system and play key roles in brain homeostasis. During anesthesia, microglia increase their dynamic process surveillance and interact more closely wit...
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Article
Open AccessAsialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes multi-organ damage, which includes hepatic dysfunction, as observed in over 50% of COVID-19 patients. Angiotensin I converting enzyme (peptid...
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Article
Time optimal controls for Hilfer fractional evolution equations
This article investigates time optimal controls for the Cauchy problem of Hilfer fractional evolution equations. At first, by employing the fixed point technique and the operator semigroup theory, an existence...
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Article
CS/CoFe2O4 nanocomposite as a high-effective and steady chainmail catalyst for tetracycline degradation with peroxymonosulfate activation: performance and mechanism
Tetracycline becomes a crucial measure for managing and treating communicable diseases in both human and animal sectors due to its beneficial antibacterial properties and cost-effectiveness. However, it is imp...
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Article
The driving factors and spatial evolution of industrial water pollution governance efficiency in the Yangtze River Delta urban agglomeration in China
In order to explore the effective path to improve the efficiency of industrial water pollution governance efficiency (WGE), this study takes 27 prefecture-level cities in the Yangtze River Delta urban agglomerati...
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Article
Unique genes carried by abundant species enhance CH4 emissions during the growing season at the Tibetan Plateau
• CH4 emission rates followed an increased pattern during the growing season at Tibetan Plateau.
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Article
Future negative time perspective and risk-taking behaviors among chinese adolescents: A longitudinal moderated mediation model
The association between future time perspective and risk-taking behaviors has received extensive empirical attention. However, the underlying mechanisms that link future negative time perspective (FNTP) to ris...
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Article
Exploration and analysis of differentially expressed genes in Epstein–Barr virus negative and positive plasmablastic lymphoma
Plasmablastic lymphoma (PBL) is a subtype of diffuse large B-cell lymphoma (DLBCL) often associated with Epstein–Barr virus (EBV) infection. Despite recent advances in treatment, PBL still has a poor prognosis...
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Article
Open AccessVOC species controlling O3 formation in ambient air and their sources in Kaifeng, China
The concentration of ozone has been in a rising crescendo in the last decade while the fine particles (PM2.5) is gradually decreasing but still at a high level in central China. Volatile organic compounds (VOCs) ...
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Article
Open AccessDifferential correlation between time in range and eGFR or albuminuria in type 2 diabetes
As a CGM-derived indicator, ‘time in range’ (TIR) is emerging as a key indicator for accurate assessment of glycaemic control. However, there is few report focusing on the correlation of TIR with albumuria and...
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Article
Open AccessA dominant variant in apoptosis-related gene XKR8 is relevant to hereditary auditory neuropathy
Auditory neuropathy is an unusual type of hearing loss. At least 40% of patients with this disease have underlying genetic causes. However, in many hereditary auditory neuropathy cases, etiology remains undete...
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Article
Nuclear respiratory factor 1 promotes the progression of EBV-associated gastric cancer and maintains EBV latent infection
This study aimed to investigate the association of Epstein-Barr virus (EBV) with nuclear respiratory factor 1 (NRF1) and the biological function of NRF1 in EBV-associated gastric cancer (EBVaGC). Western blot ...
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Article
High Qualities of Relationships with Parents and Teachers Contribute to the Development of Adolescent Life Satisfaction Through Resilience: A Three-Wave Prospective Longitudinal Study
Life satisfaction (LS) is a core dimension of subjective well-being and is linked to many life outcomes in adolescents. Among other indicators of optimal functioning in youth, LS has been understudied; not unt...
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Article
Community structure and network interaction of aerobic methane-oxidizing bacteria in Chongqing’s central urban area in the Three Gorges Reservoir, China
A reservoir is an important source of methane (CH4), which is consumed by aerobic methane-oxidizing bacteria (MOB), representing the main CH4 sink in water. The central urban area of Chongqing in the Three Gorges...
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Article
Experimental investigation on erosion progression and strength reduction of gap-graded cohesionless soil subjected to suffusion
Suffusion is a typical mode of internal erosion that leads to the deterioration of earthen structures. A stress-controlled experimental apparatus has been developed, which is adopted to investigate the charact...
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Article
Why victimized by peer promotes cyberbullying in college students? Testing a moderated mediation model in a three-wave longitudinal study
Cyberbullying is a major youth social problem over the world and it has been associated with a variety of negative outcomes. However, few studies investigated how offline peer victimization affects cyberbullyi...
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Article
Single image dehazing via cycle-consistent adversarial networks with a multi-scale hybrid encoder-decoder and global correlation loss
Deep learning technologies have been resha** the research of image dehazing in recent years with superior performance. Due to the difficulty to obtain the real hazy and corresponding clear image pairs in the...
