-
Article
Potent and specific antibiotic combination therapy against Clostridioides difficile
Keratinicyclins and keratinimicins are recently discovered glycopeptide antibiotics. Keratinimicins show broad-spectrum activity against Gram-positive bacteria, while keratinicyclins form a new chemotype by vi...
-
Article
Open AccessFreshwater microalgae Nannochloropsis limnetica for the production of β-galactosidase from whey powder
This study investigated the first-ever reported use of freshwater Nannochloropsis for the bioremediation of dairy processing side streams and co-generation of valuable products, such as β-galactosidase enzyme. In...
-
Article
Open AccessGrowth and fatty acid profile of Nannochloropsis oceanica cultivated on nano-filtered whey permeate
Nano-filtered whey permeate (WP), a major by-product of dairy industry, is produced by membrane filtration of whey. The oleaginous microalga Nannochloropsis oceanica was successfully cultivated on WP without sali...
-
Article
Open AccessCognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study
Cognitive dysfunction is one of the common symptoms in patients with major depressive disorder (MDD). Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) have...
-
Article
Effects of Bifidobacterium breve 207-1 on regulating lifestyle behaviors and mental wellness in healthy adults based on the microbiome-gut-brain axis: a randomized, double-blind, placebo-controlled trial
Our study aimed to explore the efficacy of Bifidobacterium breve 207-1 on specific neurotransmitters and hormones and the ability to regulate lifestyle behaviors in healthy adults.
-
Article
Open AccessCorrection: Preeclampsia impedes foetal kidney development by delivering placenta-derived exosomes to glomerular endothelial cells
-
Article
Open AccessHomotherapy for heteropathy: therapeutic effect of Butein in NLRP3-driven diseases
Aberrant inflammatory responses drive the initiation and progression of various diseases, and hyperactivation of NLRP3 inflammasome is a key pathogenetic mechanism. Pharmacological inhibitors of NLRP3 represen...
-
Article
A framework for implementing patient-reported outcomes in clinical care: the PROTEUS-practice guide
-
Article
COOT–SVR model: estimation of the capillary water absorption of building stones
The examination of a rock's capillary water absorption ( \(\mathrm{CWA}\) CWA ...
-
Article
Stay a While: the Retention of Immigrants in Rural Canada
In an effort to shift migration flows away from traditional immigrant destinations in favour of smaller regions throughout Canada, regionalization has been one of the most critical trends in Canadian immigrati...
-
Article
High-resolution modelling identifies the Bering Strait’s role in amplified Arctic warming
The Arctic region has warmed nearly four times faster than the global average since 1979, with far-reaching global implications. However, model projections of Arctic warming rates are uncertain and one key com...
-
Article
Open AccessAssociation of PM2.5 chemical constituents with general, abdominal and visceral obesity and mediation roles of physical activity
The association between exposure to PM2.5 chemical constituents and obesity remains to be elucidated, as most studies have used a single measure of obesity. This study aimed to investigate the associations of exp...
-
Article
Negative life events and suicidality among adolescents in Western China: the mediating effect of depressive symptoms and the moderating effect of self-esteem
To investigate the mediating role of depressive symptoms in the relationship between negative life events (NLEs) and suicidality, as well as to test the moderating effect of self-esteem in the mediation model.
-
Article
Open AccessMulti-purpose RNA language modelling with motif-aware pretraining and type-guided fine-tuning
Pretrained language models have shown promise in analysing nucleotide sequences, yet a versatile model excelling across diverse tasks with a single pretrained weight set remains elusive. Here we introduce RNAE...
-
Article
Open AccessExosomal encapsulation of miR-3198 promotes proliferation and migration of trophoblasts in preeclampsia
Preeclampsia (PE) is a vascular remodeling disorder cloesly linked to trophoblast dysfunction, involving defects in their proliferation, migration, and apoptosis. Maternal exosomal microRNAs (miRNAs) have been...
-
Article
Non-thyroidal disease syndrome in patients with systemic lupus erythematosus: relation to disease inflammatory activity
To identify risk factors for the development of non-thyroidal illness syndrome (NTIS) in patients with systemic lupus erythematosus (SLE).
-
Article
Open AccessCorrection: Inhibition of mTOR Alleviates Early Brain Injury After Subarachnoid Hemorrhage Via Relieving Excessive Mitochondrial Fission
-
Article
Translation model based on discrete Fourier transform and Skip** Sub-Layer methods
Machine translation quality has seen tremendous improvement since the development of neural machine translation. However, translation models are memory intensive, with expensive hardware facilities and slow tr...
-
Article
Open AccessConserved methylation signatures associate with the tumor immune microenvironment and immunotherapy response
Aberrant DNA methylation is a major characteristic of cancer genomes. It remains unclear which biological processes determine epigenetic reprogramming and how these processes influence the variants in the canc...
-
Article
Open AccessSynergistic inhibition effects of andrographolide and baicalin on coronavirus mechanisms by downregulation of ACE2 protein level
The SARS-CoV-2 virus, belonging to the Coronavirus genus, which poses a threat to human health worldwide. Current therapies focus on inhibiting viral replication or using anti-inflammatory/immunomodulatory compou...
