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Article
Open AccessFreshwater microalgae Nannochloropsis limnetica for the production of β-galactosidase from whey powder
This study investigated the first-ever reported use of freshwater Nannochloropsis for the bioremediation of dairy processing side streams and co-generation of valuable products, such as β-galactosidase enzyme. In...
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Article
Open AccessAlterations in immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients receiving HER2-targeted neo-adjuvant therapy
The phase II neo-adjuvant clinical trial ICORG10-05 (NCT01485926) compared chemotherapy in combination with trastuzumab, lapatinib or both in patients with HER2+ breast cancer. We studied circulating immune ce...
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Article
Open AccessMechanism of lactose assimilation in microalgae for the bioremediation of dairy processing side-streams and co-production of valuable food products
This study investigated the mechanism of lactose assimilation in Nannochloropsis oceanica for dairy-wastewater bioremediation and co-production of valuable feed/food ingredients in a circular dairy system (β-gala...
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Article
Open AccessTargeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis
Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and se...
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Article
Open AccessMagnesium Chloride promotes Osteogenesis through Notch signaling activation and expansion of Mesenchymal Stem Cells
Mesenchymal stem cells (MSC) are osteoblasts progenitors and a variety of studies suggest that they may play an important role for the health in the field of bone regeneration. Magnesium supplementation is gai...
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Article
Open AccessMetabolic risk management, physical exercise and lifestyle counselling in low-active adults: controlled randomized trial (BELLUGAT)
The primary aim of this study is to evaluate the effectiveness of different doses (intensity) of supervised exercise training — concomitant with lifestyle counselling — as a primary care intervention tool for ...
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Article
Open AccessA method for isolation of cone photoreceptors from adult zebrafish retinae
Cone photoreceptors are specialised sensory retinal neurons responsible for photopic vision, colour perception and visual acuity. Retinal degenerative diseases are a heterogeneous group of eye diseases in whic...
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Article
Vitamin D enhances reactive oxygen intermediates production in phagocytic cells in term and preterm infants
Newborn infants are endotoxin tolerant which may be responsible for their increased susceptibility to bacterial sepsis. Vitamin D has an immunomodulatory effect and newborn infants are at risk of vitamin D def...
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Article
Muscle development and body growth in larvae and early post-larvae of shi drum, Umbrina cirrosa L., reared under different larval photoperiod: muscle structural and ultrastructural study
Shi drum specimens were maintained under four different photoperiod regimes: a natural photoperiod regime (16L:8D), constant light (24L), equal durations of light and dark (12L:12D) and a reduced number of day...
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Article
Spectral signatures of hydrilla from a tank and field setting
The invasion of hydrilla in many waterways has caused significant problems resulting in high maintenance costs for eradicating this invasive aquatic weed. Present identification methods employed for detecting ...
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Article
Open AccessAn imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models
Many factors influence breast cancer progression, including the ability of progenitor cells to sustain or increase net tumour cell numbers. Our aim was to define whether alterations in putative progenitor popu...
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Article
Steroid hormone progesterone induces cell proliferation and abnormal mitotic processes in rat liver
The aim of this study was to evaluate the acute hepatic effects exerted by the steroid hormone progesterone (PR) in the rat. Although the liver is not a target tissue for this hormone, a number of hepatic act...
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Effects of the Inhibition of Nitric Oxide Synthase and Lipoxygenase on the Development of Endotoxin-Induced Uveitis
The anti-inflammatory effect of the inhibition of nitric oxide synthase (NOS) or 5lipoxygenase (5-LO), and a concomitant inhibition of both pathways were investigated on the endotoxin-induced uveitis (EIU) mod...
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Chapter
Ultraviolet Light-Induced Damage in Rabbit Corneal Epithelial Cells in Vitro
The variations of the spectral irradial of sunlight and the increasing use of artificial sources of light that emits UV-radiation, have increased the incidence of nocive effects of UV-radiation. Preliminary st...
