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Article
Open AccessProdrug-conjugated tumor-seeking commensals for targeted cancer therapy
Prodrugs have been explored as an alternative to conventional chemotherapy; however, their target specificity remains limited. The tumor microenvironment harbors a range of microorganisms that potentially serv...
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Article
Molecular dynamic study of heterocyclic compounds and carbon nanotube
This manuscript uses molecular dynamics simulations to research the self-assembly process between heterocyclic compounds and carbon nanotubes. These results show that multiple polybenzothiazole chains self-cur...
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Article
Open AccessPyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway
DNA damage and oxidative stress induced by chemotherapy are important factors in the onset of premature ovarian insufficiency (POI). Studies have shown that mitochondria derived from mesenchymal stem cells (MS...
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Article
Demystifying Benevolent Leadership: When Subordinates Feel Obligated to Undertake Illegitimate Tasks
Drawing on social exchange theory and benevolent leadership literature, we show how the largesse associated with benevolent leadership can cause subordinates to feel obliged to undertake illegitimate tasks ass...
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Article
Open AccessCircRNA ITCH Inhibits Epithelial–Mesenchymal Transformation and Promotes Apoptosis in Papillary Thyroid Carcinoma via miR-106a-5p/JAZF1 Axis
Circular RNA ITCH (circ-ITCH) is implicated in papillary thyroid carcinoma (PTC) development. Nevertheless, the more detailed molecular mechanism remains uncovered. The transcriptional level of circ-ITCH was t...
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Article
Microbial engineering strategies to utilize waste feedstock for sustainable bioproduction
The desire to move from a fossil fuel-based ‘take–make–dispose’ economy to a bio-based circular economy has generated great interest in microbial metabolic engineering for its ability to create cell factories ...
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Article
Open AccessMicrobiome convergence enables siderophore-secreting-rhizobacteria to improve iron nutrition and yield of peanut intercropped with maize
Intercrop** has the potential to improve plant nutrition as well as crop yield. However, the exact mechanism promoting improved nutrient acquisition and the role the rhizosphere microbiome may play in this p...
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Article
Open AccessMultiple venous thromboembolisms in a pregnant patient carrying a novel mutation in SERPINC1 (p.M313T) that causes a transient antithrombin deficiency: a case report
Congenital antithrombin deficiency is an autosomal dominant disease that results in deep venous thrombosis and pulmonary embolism, which is mainly caused by mutations in the antithrombin gene (SERPINC1). Since SE...
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Article
Open AccessVascular endothelial growth factor induces the migration of human airway smooth muscle cells by activating the RhoA/ROCK pathway
Airway remodeling due to increased airway smooth muscle cell (ASMC) mass, likely due to enhanced proliferation, hypertrophy, and migration, has been proven to be highly correlated with decreased lung function ...
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Article
Open AccessGenetic parameters, reciprocal cross differences, and age-related heterosis of egg-laying performance in chickens
Egg-laying performance is economically important in poultry breeding programs. Crossbreeding between indigenous and elite commercial lines to exploit heterosis has been an upward trend in traditional layer bre...
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Article
Open Access**nyang tablet ameliorates sepsis-induced myocardial dysfunction by regulating Beclin-1 to mediate macrophage autophagy and M2 polarization through LncSICRNT1 targeting E3 ubiquitin ligase TRAF6
**nyang Tablet (XYT) has emerged as a potential intervention to counter sepsis-induced myocardial dysfunction (SMID) by influencing macrophage autophagy and M2 polarization. This study aimed to unravel the und...
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Article
Open AccessThe mRNA-lncRNA landscape of multiple tissues uncovers key regulators and molecular pathways that underlie heterosis for feed intake and efficiency in laying chickens
Heterosis is routinely exploited to improve animal performance. However, heterosis and its underlying molecular mechanism for feed intake and efficiency have been rarely explored in chickens. Feed efficiency c...
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Article
Open AccessO-GlcNAcylation Modification in Immune Cells: Potential Therapeutic Implications of Sepsis
O-GlcNAc modification is a glycosylation modification that is commonly observed in nuclear and organelle proteins of cells. In recent years, several studies have shown that O-GlcNAc modification plays an impor...
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Article
Open AccessPhysicochemical and Functional Similarity Assessment Between Proposed Bevacizumab Biosimilar BAT1706 and Reference Bevacizumab
BAT1706 is a proposed biosimilar of bevacizumab, a vascular endothelial growth factor A (VEGF-A)-targeting biologic used to treat several different cancers, including metastatic colorectal cancer. A comprehens...
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Article
GABA responds to low phosphorus stress by interfering with endogenous auxin levels in apple
As the immobility of inorganic phosphorus (P) in soil, the acquisition of P by sessile plants is limited. γ-Aminobutyric acid (GABA) as a signal molecule and a metabolite can regulate plants to cope with vario...
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Article
Role of adrenal venous sampling in the differential diagnosis and treatment protocol of ACTH-independent Cushing’s syndrome with bilateral adrenal lesions
The diagnosis and management of adrenocorticotropic hormone-independent Cushing’s syndrome (AICS) with bilateral adrenal lesions remain challenging. Some studies have explored the value of adrenal vein samplin...
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Article
Effect of alkaline electrolyte concentration on energy storage of core–shell structured MoSe2-PANI as supercapacitor electrode materials
Molybdenum selenide (MoSe2) has attracted considerable attention for supercapacitor due to its comparatively high conductivity and large capacity compared to other transition metal dichalcogenides (TMDs). Therefo...
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Article
Open AccessEffect of platelet concentrates for pain and symptom management in oral lichen planus: an evidence-based systematic review
Platelet Concentrate (PC) injection therapy has shown potential as a local therapy for oral lichen planus (OLP). However, its safety and efficacy have not yet been fully established. Our research compared the ...
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Article
Open AccessCorrelation between negative life events and suicide attempts among Yi adolescents with HIV/AIDS in Liangshan Prefecture
To investigate the incidence of suicide attempts among adolescents with HIV/AIDS in Liangshan Prefecture, Sichuan Province, as well as the correlation between negative life events, sleep, exercise, drug therap...
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Article
Open AccessCombined analysis of the proteome and metabolome provides insight into microRNA-1174 function in Aedes aegypti mosquitoes
Pathogenic viruses can be transmitted by female Aedes aegypti (Ae. aegypti) mosquitoes during blood-meal acquisition from vertebrates. Silencing of mosquito- and midgut-specific microRNA (miRNA) 1174 (miR-1174) i...
