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Article
Open AccessDemonstration of Physicochemical and Functional Similarity of the Biosimilar BAT1806/BIIB800 to Reference Tocilizumab
Tocilizumab is an immunoglobulin G1 monoclonal antibody targeting the interleukin-6 receptor (IL-6R). BAT1806/BIIB800 (tocilizumab-bavi) has been developed as a biosimilar to the reference product tocilizumab ...
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Article
Open AccessIdentification and characterization of Varicella Zoster Virus circular RNA in lytic infection
This study investigates the role of circular RNAs (circRNAs) in the context of Varicella-Zoster Virus (VZV) lytic infection. We employ two sequencing technologies, short-read sequencing and long-read sequencin...
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Article
Open AccessValue of radiological depth of invasion in non-pT4 Oral tongue squamous cell carcinoma: implication for preoperative MR T-staging
The prognostic stratification for oral tongue squamous cell carcinoma (OTSCC) is heavily based on postoperative pathological depth of invasion (pDOI). This study aims to propose a preoperative MR T-staging sys...
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Article
Removal of cadmium from aqueous solution by magnetic biochar: adsorption characteristics and mechanism
Experiments were conducted to investigate the potential of the efficient resource utilization of waste cow manure and corn straw in an agricultural ecosystem. In this study, a magnetic cow manure and straw bio...
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Article
Open AccessZSP1601, a novel pan-phosphodiesterase inhibitor for the treatment of NAFLD, A randomized, placebo-controlled phase Ib/IIa trial
Non-alcoholic fatty liver disease is a growing health burden with limited treatment options worldwide. Herein we report a randomized, double-blind, placebo-controlled, multiple-dose trial of a first-in-class p...
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Article
Basketball assisted teaching in instructional videos based on Mobile Edge Computing
Many teachers are limited by the teaching contents in physical education, which makes it impossible to show students some skilled movements, so students do not have enough time to learn about those abstract an...
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Article
Impact of China’s carbon emissions trading scheme on urban air quality: a time-varying DID model
Using panel data for 277 Chinese cities, this paper applies a time-varying difference-in-differences (DID) model to empirically test the impact of China’s carbon emissions trading scheme (ETS) on urban air qua...
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Article
Open AccessPhysicochemical and Functional Similarity Assessment Between Proposed Bevacizumab Biosimilar BAT1706 and Reference Bevacizumab
BAT1706 is a proposed biosimilar of bevacizumab, a vascular endothelial growth factor A (VEGF-A)-targeting biologic used to treat several different cancers, including metastatic colorectal cancer. A comprehens...
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Article
Refractive status and retinal morphology in children with a history of intravitreal ranibizumab for retinopathy of prematurity
This study investigated the characteristics of refractive status, visual acuity, and retinal morphology in children with a history of receiving intravitreal ranibizumab for retinopathy of prematurity (ROP). Ch...
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Article
Prediction of electronic structure and thermoelectric performance of bulk and monolayer BiSbSeTe2
Thermoelectric materials have many advantages, such as long service life, small size, light weight and so on. High efficient thermoelectric conversion materials are used in navigation satellites and play an im...
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Article
Open AccessElectro-acupuncture reduced steatosis on MRI-PDFF in patients with non-alcoholic steatohepatitis: a randomized controlled pilot clinical trial
Non-alcoholic steatohepatitis (NASH) had not yet been approved therapy. Electro-acupuncture (EA) has been reported to have potential efficacy. However, high-quality clinical evidence was still lacking.
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Article
Open AccessAn enhanced whale optimization algorithm with improved dynamic opposite learning and adaptive inertia weight strategy
Whale Optimization Algorithm (WOA), as a newly proposed swarm-based algorithm, has gradually become a popular approach for optimization problems in various engineering fields. However, WOA suffers from the poo...
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Article
Prognosis of Liver Transplantation for Hepatocellular Carcinoma in Terms of Different Criteria: A Single Center Experience
Patients undergoing liver transplantation for hepatocellular carcinoma (HCC) within the Milan criteria have an excellent outcome. We developed a program to analyze and prove that the Milan criteria can be expa...
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Article
Open AccessComparison of reader agreement, correlation with liver biopsy, and time-burden sampling strategies for liver proton density fat fraction measured using magnetic resonance imaging in patients with obesity: a secondary cross-sectional study
The magnetic resonance imaging (MRI)-based proton density fat fraction (PDFF) has become popular for quantifying liver fat content. However, the variability of the region-of-interest (ROI) sampling strategy ma...
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Article
Characteristics and formation mechanism of siltstone-mudstone rhythmic sedimentary sections in the Lower Silurian Longmaxi Formation in the Changning area, South Sichuan Basin, southwest China
The Lower Member of the Longmaxi Formation is generally dominated by siliceous shale, but recently we found some siltstone-mudstone rhythm sections developed in the Lower Member of the Longmaxi Formation. The ...
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Article
Open AccessLipidomics reveals that sustained SREBP-1-dependent lipogenesis is a key mediator of gefitinib-acquired resistance in EGFR-mutant lung cancer
Patients with EGFR mutations in non-small cell lung cancer (NSCLC) have been greatly benefited from gefitinib, however, the therapeutic has failed due to the presence of acquired resistance. In this study, we ...
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Article
Open AccessSubstantially enhanced plasticity of bulk metallic glasses by densifying local atomic packing
Introducing regions of looser atomic packing in bulk metallic glasses (BMGs) was reported to facilitate plastic deformation, rendering BMGs more ductile at room temperature. Here, we present a different alloy ...
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Article
Long-term survival in patients with distal cholangiocarcinoma after pancreaticoduodenectomy combined with portal vein system resection and reconstruction
Pancreaticoduodenectomy combined with portal vein resection for distal cholangiocarcinoma is rarely reported because it is a rare disease. We developed a program to evaluate the vascular invasion type, operati...
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Article
Open AccessPrognostic impact of lymph node parameters in distal cholangiocarcinoma after pancreaticoduodenectomy
Pancreaticoduodenectomy is the only definitively curative therapy for the long-term survival of distal cholangiocarcinoma patients. Lymph node metastasis is widely accepted as an important prognostic factor fo...
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Article
The Clinical Value and Appropriateness Criteria of Upper Abdominal Magnetic Resonance Examinations in Patients Before and After Bariatric Surgery: a Study of 837 Images
The abdominal magnetic resonance (MR) examinations have been increasingly applied in patients with obesity. However, few studies analyzed the appropriateness of this examination. This study is aimed to evaluat...
