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Open AccessThe antagonistic effect of FTO on METTL14 promotes AKT3 m6A demethylation and the progression of esophageal cancer
As the most abundant modification in eukaryotic messenger RNAs (mRNAs), N6-methyladenosine (m6A) plays vital roles in many biological processes.
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Open AccessExperimental study on deterioration of bedrock strength and P-wave velocity by pressurized seawater
Bedrock has to be excavated before the construction of rock-socketed pile foundations for offshore wind power turbines, leading to the exposure of fresh and dry rocks to seawater. The pile-rock interface is pa...
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Open AccessCorrection to: ED50 of Propofol Combined with Nalbuphine on the Sedative Effect in Painless Hysteroscopy
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Open AccessApplication of opioid-free general anesthesia for gynecological laparoscopic surgery under ERAS protocol: a non-inferiority randomized controlled trial
Enhanced recovery after surgery (ERAS) is now widely used in various surgical fields including gynecological laparoscopic surgery, but the advantages of opioid-free anesthesia (OFA) in gynecological laparoscop...
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Article
Optimization of the digital image correlation method for deformation measurement of geomaterials
For the application of the digital image correlation (DIC) method in the deformation measurement of geomaterials, the conventional approaches can hardly realize optimized results in terms of precision and spee...
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Investigation on the Collapse Mechanism of Overlying Clay Layer Based on the Unified Strength Theory
Water and sand gushing will lead to the destruction of upper cohesive soil that further form cavity, and the ground collapse caused by the development of soil cavity adversely affects the geotechnical building...
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Article
Propofol Protects Against Erastin-Induced Ferroptosis in HT-22 Cells
Propofol is a short-acting intravenous anesthetic that is widely used in clinical treatment. Previous articles have indicated that propofol is a therapeutic target for anti-apoptosis, anti-inflammation, anti-l...
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Open AccessA novel epithelial–mesenchymal transition gene signature for the immune status and prognosis of hepatocellular carcinoma
This study clarified whether EMT-related genes can predict immunotherapy efficacy and overall survival in patients with HCC.
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Open AccessComparison of Two Ultrasound-guided Plane Blocks for Pain and Postoperative Opioid Requirement in Lumbar Spine Fusion Surgery: A Prospective, Randomized, and Controlled Clinical Trial
The erector spinae plane (ESP) block and thoracolumbar interfascial plane (TLIP) block were two novel plane blocks. The purpose of this study was to investigate TLIP block and ESP block on the effect of analge...
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Article
Open AccessED50 of Propofol Combined with Nalbuphine on the Sedative Effect in Painless Hysteroscopy
Nalbuphine has gradually become a commonly used clinical analgesic drug for painless hysteroscopy. The aim of our study was to identify the median effective dose (ED50) of propofol combined with nalbuphine for...
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Article
Open AccessEffects of lidocaine, dexmedetomidine, and their combination infusion on postoperative nausea and vomiting following laparoscopic hysterectomy: a randomized controlled trial
A few studies have reported that administration of lidocaine and dexmedetomidine relieves the incidence of postoperative nausea and vomiting (PONV). We explored whether combined infusion of lidocaine plus dexm...
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Open AccessEffects of intravenous lidocaine, dexmedetomidine, and their combination on IL-1, IL-6 and TNF-α in patients undergoing laparoscopic hysterectomy: a prospective, randomized controlled trial
Surgical-related inflammatory responses have negative effects on postoperative recovery. Intravenous (IV) lidocaine and dexmedetomidine inhibits the inflammatory response. We investigated whether the co-admini...
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Experimental Investigation of the Deformation and Failure Behavior of a Tunnel Excavated in Mixed Strata Using Transparent Soft Rock
To investigate the deformation and failure behavior of a tunnel excavated in mixed strata, transparent soft rock test and numerical simulations were performed. The distribution features of displacement and fai...
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Open AccessEffects of intravenous infusion of lidocaine and dexmedetomidine on inhibiting cough during the tracheal extubation period after thyroid surgery
Intravenous lidocaine and dexmedetomidine treatments have been proposed as methods for inhibiting cough. We compared the efficacy of intravenous lidocaine and dexmedetomidine treatments on inhibiting cough dur...
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Open AccessDetermination of the median effective dose (ED50) of bupivacaine and ropivacaine unilateral spinal anesthesia
Unilateral spinal anesthesia (USpA) has been reported to potentiate spinal anaesthesia and is used in geriatric patients. The purpose of this study was to determine the median effective dose (ED50) of 0.5% hypoba...
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Tramadol differentially regulates M1 and M2 macrophages from human umbilical cord blood
Tramadol is an analgesic drug and relieves pain through activating μ-opioid receptors and inhibiting serotonin and noradrenaline reuptake. Emerging evidence shows that it also stimulates immune cells, includin...
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Open AccessSevoflurane decreases self-renewal capacity and causes c-Jun N-terminal kinase–mediated damage of rat fetal neural stem cells
Increasing studies have demonstrated that sevoflurane can induce neurotoxicity in the develo** brains. JNK normally promotes apoptosis. It was hypothesized that sevoflurane affected the proliferation and dif...
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Identification of miRNAs Involved in the Protective Effect of Sevoflurane Preconditioning Against Hypoxic Injury in PC12 Cells
The mechanism of sevoflurane preconditioning-induced neuroprotection is poorly understood. This study was aimed at identifying microRNAs (miRNAs) involved in the protective effect of sevoflurane preconditionin...
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Endoplasmic Reticulum Stress is Involved in the Neuroprotective Effect of Propofol
Propofol is a common clinically used intravenous anaesthetic agent with antioxidative property. It has been thought to have neuroprotection in vitro and in vivo. However, the underlying mechanisms remain uncl...