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  1. Article

    Open Access

    The antagonistic effect of FTO on METTL14 promotes AKT3 m6A demethylation and the progression of esophageal cancer

    As the most abundant modification in eukaryotic messenger RNAs (mRNAs), N6-methyladenosine (m6A) plays vital roles in many biological processes.

    Ran Wei, Fangfang Zhao, Lingsuo Kong in Journal of Cancer Research and Clinical On… (2024)

  2. Article

    Open Access

    Experimental study on deterioration of bedrock strength and P-wave velocity by pressurized seawater

    Bedrock has to be excavated before the construction of rock-socketed pile foundations for offshore wind power turbines, leading to the exposure of fresh and dry rocks to seawater. The pile-rock interface is pa...

    Qi Zhang, Chenhao Zhang, Yifeng Lin in Geomechanics and Geophysics for Geo-Energy… (2023)

  3. Article

    Open Access

    Correction to: ED50 of Propofol Combined with Nalbuphine on the Sedative Effect in Painless Hysteroscopy

    Chen Chen, Weixiang Tang, Wei Ye, Weiwei Zhong, Yuanhai Li in Pain and Therapy (2023)

  4. Article

    Open Access

    Application of opioid-free general anesthesia for gynecological laparoscopic surgery under ERAS protocol: a non-inferiority randomized controlled trial

    Enhanced recovery after surgery (ERAS) is now widely used in various surgical fields including gynecological laparoscopic surgery, but the advantages of opioid-free anesthesia (OFA) in gynecological laparoscop...

    Liang Chen, Wensheng He, Xue Liu, Fahui Lv, Yuanhai Li in BMC Anesthesiology (2023)

  5. No Access

    Article

    Optimization of the digital image correlation method for deformation measurement of geomaterials

    For the application of the digital image correlation (DIC) method in the deformation measurement of geomaterials, the conventional approaches can hardly realize optimized results in terms of precision and spee...

    YuanHai Li, **aoJie Tang, HongHu Zhu in Acta Geotechnica (2022)

  6. No Access

    Article

    Investigation on the Collapse Mechanism of Overlying Clay Layer Based on the Unified Strength Theory

    Water and sand gushing will lead to the destruction of upper cohesive soil that further form cavity, and the ground collapse caused by the development of soil cavity adversely affects the geotechnical building...

    Fan Chen, Yingchao Wang, Yuanhai Li, Wen Jiang in KSCE Journal of Civil Engineering (2022)

  7. No Access

    Article

    Propofol Protects Against Erastin-Induced Ferroptosis in HT-22 Cells

    Propofol is a short-acting intravenous anesthetic that is widely used in clinical treatment. Previous articles have indicated that propofol is a therapeutic target for anti-apoptosis, anti-inflammation, anti-l...

    Wenting Xuan, **nyi Lu, Zeyong Yang, Jun Li in Journal of Molecular Neuroscience (2022)

  8. Article

    Open Access

    A novel epithelial–mesenchymal transition gene signature for the immune status and prognosis of hepatocellular carcinoma

    This study clarified whether EMT-related genes can predict immunotherapy efficacy and overall survival in patients with HCC.

    Yanlong Shi, **gyan Wang, Guo Huang, Jun Zhu, Haokun Jian in Hepatology International (2022)

  9. Article

    Open Access

    Comparison of Two Ultrasound-guided Plane Blocks for Pain and Postoperative Opioid Requirement in Lumbar Spine Fusion Surgery: A Prospective, Randomized, and Controlled Clinical Trial

    The erector spinae plane (ESP) block and thoracolumbar interfascial plane (TLIP) block were two novel plane blocks. The purpose of this study was to investigate TLIP block and ESP block on the effect of analge...

    Lizhen Wang, Ying Wu, Lianjie Dou, Ke Chen, Yuesheng Liu, Yuanhai Li in Pain and Therapy (2021)

  10. Article

    Open Access

    ED50 of Propofol Combined with Nalbuphine on the Sedative Effect in Painless Hysteroscopy

    Nalbuphine has gradually become a commonly used clinical analgesic drug for painless hysteroscopy. The aim of our study was to identify the median effective dose (ED50) of propofol combined with nalbuphine for...

    Chen Chen, Weixiang Tang, Wei Ye, Weiwei Zhong, Yuanhai Li in Pain and Therapy (2021)

  11. Article

    Open Access

    Effects of lidocaine, dexmedetomidine, and their combination infusion on postoperative nausea and vomiting following laparoscopic hysterectomy: a randomized controlled trial

    A few studies have reported that administration of lidocaine and dexmedetomidine relieves the incidence of postoperative nausea and vomiting (PONV). We explored whether combined infusion of lidocaine plus dexm...

    Siqi Xu, Shengbin Wang, Shenghong Hu, **a Ju, Qing Li, Yuanhai Li in BMC Anesthesiology (2021)

  12. Article

    Open Access

    Effects of intravenous lidocaine, dexmedetomidine, and their combination on IL-1, IL-6 and TNF-α in patients undergoing laparoscopic hysterectomy: a prospective, randomized controlled trial

    Surgical-related inflammatory responses have negative effects on postoperative recovery. Intravenous (IV) lidocaine and dexmedetomidine inhibits the inflammatory response. We investigated whether the co-admini...

    Siqi Xu, Shenghong Hu, **a Ju, Yuanhai Li, Qing Li, Shengbin Wang in BMC Anesthesiology (2021)

  13. No Access

    Article

    Experimental Investigation of the Deformation and Failure Behavior of a Tunnel Excavated in Mixed Strata Using Transparent Soft Rock

    To investigate the deformation and failure behavior of a tunnel excavated in mixed strata, transparent soft rock test and numerical simulations were performed. The distribution features of displacement and fai...

    Yuanhai Li, Shuo Yang, **aojie Tang, Yanfeng Ding in KSCE Journal of Civil Engineering (2020)

  14. Article

    Open Access

    Effects of intravenous infusion of lidocaine and dexmedetomidine on inhibiting cough during the tracheal extubation period after thyroid surgery

    Intravenous lidocaine and dexmedetomidine treatments have been proposed as methods for inhibiting cough. We compared the efficacy of intravenous lidocaine and dexmedetomidine treatments on inhibiting cough dur...

    Shenghong Hu, Yuanhai Li, Shengbin Wang, Siqi Xu, **a Ju, Li Ma in BMC Anesthesiology (2019)

  15. Article

    Open Access

    Determination of the median effective dose (ED50) of bupivacaine and ropivacaine unilateral spinal anesthesia

    Unilateral spinal anesthesia (USpA) has been reported to potentiate spinal anaesthesia and is used in geriatric patients. The purpose of this study was to determine the median effective dose (ED50) of 0.5% hypoba...

    WeiBing Wang, YuanHai Li, AiJiao Sun, Hong** Yu, **gChun Dong in Der Anaesthesist (2017)

  16. No Access

    Article

    Tramadol differentially regulates M1 and M2 macrophages from human umbilical cord blood

    Tramadol is an analgesic drug and relieves pain through activating μ-opioid receptors and inhibiting serotonin and noradrenaline reuptake. Emerging evidence shows that it also stimulates immune cells, includin...

    Jun Zhang, Liang Chen, Yunyun Sun, Yuanhai Li in Inflammopharmacology (2017)

  17. Article

    Open Access

    Sevoflurane decreases self-renewal capacity and causes c-Jun N-terminal kinase–mediated damage of rat fetal neural stem cells

    Increasing studies have demonstrated that sevoflurane can induce neurotoxicity in the develo** brains. JNK normally promotes apoptosis. It was hypothesized that sevoflurane affected the proliferation and dif...

    Zeyong Yang, **g**g Lv, **ngxing Li, Qiong Meng, Qiling Yang in Scientific Reports (2017)

  18. No Access

    Article

    Identification of miRNAs Involved in the Protective Effect of Sevoflurane Preconditioning Against Hypoxic Injury in PC12 Cells

    The mechanism of sevoflurane preconditioning-induced neuroprotection is poorly understood. This study was aimed at identifying microRNAs (miRNAs) involved in the protective effect of sevoflurane preconditionin...

    Yingying Sun, Yuanhai Li, Lei Liu, Yiqiao Wang in Cellular and Molecular Neurobiology (2015)

  19. No Access

    Article

    Endoplasmic Reticulum Stress is Involved in the Neuroprotective Effect of Propofol

    Propofol is a common clinically used intravenous anaesthetic agent with antioxidative property. It has been thought to have neuroprotection in vitro and in vivo. However, the underlying mechanisms remain uncl...

    Likui Wang, Weixiang Tang, Tongcui Jiang, Peng Lu, Yuanhai Li in Neurochemical Research (2014)