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Article
Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein
RNA interference (RNAi) is a conserved sequence-specific gene regulatory mechanism1,2,3 mediated by the RNA-induced silencing complex (RISC), which is composed of a single-stranded guide RNA and an Argonaute prot...
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Article
A possible hydrolysis mechanism of β-naphthyl acetate catalyzed by antibodies
The mechanism of ester hydrolysis has been extensively studied; however, the precise function of active-site residues in promoting catalysis is unclear. We describe here the structural models for the complex o...
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Article
Structural analysis and molecular modeling of two anti-trichosanthin IgE clones from phage antibody library
Recently we constructed a murine IgE phage surface display library and screened out two IgE (Fab) clones with specific binding activity to Trichosanthin (TCS). In this work, the V ɛ and V κ genes of the two clone...