538 Result(s)

Article

An artificial intelligence system for comprehensive pathologic outcome prediction in early gastric cancer through endoscopic image analysis (with video)

Accurate prediction of pathologic results for early gastric cancer (EGC) based on endoscopic findings is essential in deciding between endoscopic and surgical resection. This study aimed to develop an artifici...

Seunghan Lee, Jiwoon Jeon, **bae Park, Young Hoon Chang, Cheol Min Shin… in Gastric Cancer (2024)

Article

Persistent poverty disparities in incidence and outcomes among oral and pharynx cancer patients

Disparities in oral cavity and pharyngeal cancer based on race/ethnicity and socioeconomic status have been reported, but the impact of living within areas that are persistently poor at the time of diagnosis a...

Shama Karanth, Shilpi Mistry, Meghann Wheeler, Tomi Akinyemiju… in Cancer Causes & Control (2024)

Article

Intravesical instillation-based mTOR-STAT3 dual targeting for bladder cancer treatment

Recent intravesical administration of adenoviral vectors, either as a single injection or in combination with immune checkpoint inhibitors, exemplified by cretostimogene grenadenorepvec and nadofaragene firade...

Dae Hoon Lee, Jung Ki Yoo, Ki Hwan Um… in Journal of Experimental & Clinical Cancer … (2024)

Article

Prediction of TKI response in EGFR-mutant lung cancer patients-derived organoids using malignant pleural effusion

Patient-derived organoids (PDOs) are valuable in predicting response to cancer therapy. PDOs are ideal models for precision oncologists. However, their practical application in guiding timely clinical decision...

Sang-Hyun Lee, Kyuhwan Kim, Eunyoung Lee, Kyungmin Lee… in npj Precision Oncology (2024)

Article

Generation of sarconoids from angiosarcoma patients as a systematic-based rational approach to treatment

Angiosarcoma is a rare subtype of malignant neoplasm originating from vascular or lymphatic endothelial cells; its low incidence has posed significant challenges for comprehensive investigations into its patho...

Da Jung Jung, Jae Hee Byeon, Young Chul Kim… in Journal of Hematology & Oncology (2024)

Article

Epithelial−mesenchymal transition induced by tumor cell-intrinsic PD-L1 signaling predicts a poor response to immune checkpoint inhibitors in PD-L1-high lung cancer

We investigated the role of tumor cell-intrinsic PD-L1 signaling in the epithelial−mesenchymal transition (EMT) in non-small-cell lung cancer (NSCLC) and the role of EMT as a predictive biomarker for immune ch...

Hyein Jeong, Jaemoon Koh, Sehui Kim, Seung Geun Song… in British Journal of Cancer (2024)

Article

Single-cell transcriptome analysis reveals subtype-specific clonal evolution and microenvironmental changes in liver metastasis of pancreatic adenocarcinoma and their clinical implications

Intratumoral heterogeneity (ITH) and tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) play important roles in tumor evolution and patient outcomes. However, the precise characterization ...

Joo Kyung Park, Hyoung-oh Jeong, Hyemin Kim, ** Ho Choi, Eun Mi Lee… in Molecular Cancer (2024)

Article

Single-cell RNA sequencing reveals myeloid and T cell co-stimulation mediated by IL-7 anti-cancer immunotherapy

Immune checkpoint inhibitors unleash inhibitory signals on T cells conferred by tumors and surrounding stromal cells. Despite the clinical efficacy of checkpoint inhibitors, the lack of target expression and p...

Hye Hyeon Eum, Dasom Jeong, Nayoung Kim, Areum Jo, Minsu Na… in British Journal of Cancer (2024)

Article

RNA expression of 6 genes from metastatic mucosal gastric cancer serves as the global prognostic marker for gastric cancer with functional validation

Molecular analysis of advanced tumors can increase tumor heterogeneity and selection bias. We developed a robust prognostic signature for gastric cancer by comparing RNA expression between very rare early gast...

Yun-Suhk Suh, Jieun Lee, Joshy George, Donghyeok Seol… in British Journal of Cancer (2024)

Article

Long-term oncologic outcomes of unselected triple-negative breast cancer patients according to BRCA1/2 mutations

Triple-negative breast cancer (TNBC) patients are more likely to have BRCA1/2 mutations, with a prevalence rate of about 10–20%. Although several studies have analyzed the oncologic outcomes between BRCA1/2 carri...

Woong Ki Park, Soo Yeon Chung, You ** Jung, Changhee Ha… in npj Precision Oncology (2024)

Article

Outcomes of sentinel node biopsy according to MRI response in an association with the subtypes in cN1–3 breast cancer after neoadjuvant systemic therapy, multicenter cohort study

This study investigated the feasibility of sentinel lymph node biopsy (SLNB) after neoadjuvant systemic therapy (NAST) in patients with initially high nodal burden.

Soong June Bae, Jung Whan Chun, Sae Byul Lee, Jai Min Ryu… in Breast Cancer Research (2024)

Article

Relationship of FDG PET/CT imaging features with tumor immune microenvironment and prognosis in colorectal cancer: a retrospective study

Imaging features of colorectal cancers on 2-deoxy-2-[¹⁸F]fluoro-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT) have been considered to be affected by tumor characteristics and tumor imm...

Jeong Won Lee, Hyein Ahn, Ik Dong Yoo, Sun-pyo Hong, Moo-Jun Baek… in Cancer Imaging (2024)

Article

Selective omission of sentinel lymph node biopsy in mastectomy for ductal carcinoma in situ: identifying eligible candidates

Sentinel lymph node biopsy (SLNB) is recommended for patients with ductal carcinoma in situ (DCIS) undergoing mastectomy, given the concerns regarding upstaging and technical difficulties of post-mastectomy SL...

Soong June Bae, Yoonwon Kook, Ji Soo Jang, Seung Ho Baek… in Breast Cancer Research (2024)

Article

Association of preoperative sarcopenia with the long-term prognosis of patients with bladder cancer undergoing radical cystectomy

This retrospective study aimed to assess the correlation between preoperative sarcopenia and long-term oncologic outcomes in patients undergoing radical cystectomy for bladder cancer.

Sangmin Lee, Youngjoon Yoon, Jungyo Suh… in Journal of Cancer Research and Clinical On… (2024)

Article

ASO Visual Abstract: Risk Factor Analysis of Lymph Node Metastasis for Rectal Neuroendocrine Tumor: Who Needs a Radical Resection for the Rectal Neuroendocrine Tumor 1–2 cm in Size?

** Sun Choi MD, Min Jung Kim MD, PhD, Rumi Shin MD, PhD… in Annals of Surgical Oncology (2024)

Article

AF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis

Neuroblastoma is the most common extracranial malignant tumor of childhood, accounting for 15% of all pediatric cancer deaths. Despite significant advances in our understanding of neuroblastoma biology, five-y...

Babak Oskouian, Joanna Y. Lee, Shahab Asgharzadeh, Ranjha Khan, Meng Zhang… in Oncogene (2024)

Article

Ovarian Suppression: Early Menopause and Late Effects

Around 90% of breast tumours are diagnosed in the early stage, with approximately 70% being hormone receptor-positive. The cornerstone of adjuvant therapy for early-stage hormone receptor-positive breast cance...

Chiara Molinelli MD, Flavia Jacobs MD… in Current Treatment Options in Oncology (2024)

Article

Factors associated with engraftment success of patient-derived xenografts of breast cancer

Patient-derived xenograft (PDX) models serve as a valuable tool for the preclinical evaluation of novel therapies. They closely replicate the genetic, phenotypic, and histopathological characteristics of prima...

Jongwon Lee, GunHee Lee, Hye Seon Park, Byung-Kwan Jeong… in Breast Cancer Research (2024)

Article

Transgelin-2, a novel cancer stem cell-related biomarker, is a diagnostic and therapeutic target for biliary tract cancer

Biliary tract cancer (BTC) is a relatively rare but aggressive gastrointestinal cancer with a high mortality rate. Cancer stem cell (CSC) populations play crucial roles in tumor biology and are responsible for...

Jung Hyun Jo, Soo Been Park, Joowon Chung, Taeyun Oh, Hee Seung Lee… in BMC Cancer (2024)

Article

Retraction Note: Lymphatic metastasis-related TBL1XR1 enhances stemness and metastasis in gastric cancer stem-like cells by activating ERK1/2-SOX2 signaling

Jun Lu, Hee** Bang, Su Mi Kim, Soo-Jeong Cho, Hassan Ashktorab, Duane T. Smoot… in Oncogene (2024)