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Article
Open AccessAF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis
Neuroblastoma is the most common extracranial malignant tumor of childhood, accounting for 15% of all pediatric cancer deaths. Despite significant advances in our understanding of neuroblastoma biology, five-y...
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Article
A novel NPHP4 homozygous missense variant identified in infertile brothers with multiple morphological abnormalities of the sperm flagella
Asthenozoospermia is an important cause of male infertility, and the most serious type is characterized by multiple morphological abnormalities of the sperm flagella (MMAF). However, the precise etiology of MM...
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Article
Open AccessComparative study of microscale and macroscale technique for encapsulation of Calotropis gigantea extract in metal-conjugated nanomatrices for invasive ductal carcinoma
The encapsulation of plant extract in nanomatrices has limitations due to its adhesion to walls, size control, high cost and long durations that results in low yield. Macroscale and microscale level techniques...
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Article
DNAzyme signal amplification based on Au@Ag core–shell nanorods for highly sensitive SERS sensing miRNA-21
Here, we developed a surface-enhanced Raman scattering (SERS) sensor based on functionalized Au@Ag core–shell nanorods (Au@Ag NRs) and cascade DNAzyme amplifier (CSA) for sensitive and accurate determination o...
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Chapter
Transcriptional Control Leading to Clinical Outcomes in Breast Cancer Cases
Transcription is an important event that use information from a gene and make its protein. Specific transcription factors are involved in the process that plays a role in generating gene expression. One of the...
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Article
Inactivation of testis-specific gene C4orf46 is dispensable for spermatogenesis and fertility in mouse
Several genes have been reported to be involved in spermatogenesis but their functional importance in male fertility is yet needed to be elucidated. Therefore, in current research, we focused to explore the in...
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Article
Correlation of MSH2 exonic deletions and protein downregulation with breast cancer biomarkers and outcome in Pakistani women/patients
Mismatch repair (MMR) pathway is one of the underlying mechanisms of predisposition to breast cancer (BC). The present study explored the association of MSH2 exonic deletions, respective survival analysis, pro...
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Article
Evolutionarily conserved and testis-specific gene, 4930524B15Rik, is not essential for mouse spermatogenesis and fertility
Thousands of genes are involved in spermatogenesis, however, the functional roles of most these genes for male fertility remain to be discovered. This research focused to explore the function of evolutionarily...
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Article
A highly sensitive DNAzyme-based SERS biosensor for quantitative detection of lead ions in human serum
Lead ions (Pb2+), one form of the toxic heavy metal, have drawn significant attention due to their harmful effects on human health and the environment. Although many analytical techniques have been developed over...
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Article
Microfluidic platform for encapsulation of plant extract in chitosan microcarriers embedding silver nanoparticles for breast cancer cells
In this study, the controlled synthesis of microcarriers and CpE loading were aimed to achieve by microfluidic system. The effect of temperature on chitosan in the stabilization of silver nanoparticles, microc...
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Article
Au@Ag core-shell nanoparticles for microRNA-21 determination based on duplex-specific nuclease signal amplification and surface-enhanced Raman scattering
A novel surface-enhanced Raman scattering (SERS) analysis strategy has been designed combining Au@DTNB@Ag core-shell nanoparticles (DTNB attachment on gold nanoparticles, then encapsulated in Ag shell nanoparticl...
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Article
The deubiquitinating gene Usp29 is dispensable for fertility in male mice
The balanced actions between ubiquitination and deubiquitination precisely control the levels of various proteins vital for spermatogenesis. Ubiquitin-specific processing proteases (USPs) are the largest famil...
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Article
CDKN2A/P16INK4A variants association with breast cancer and their in-silico analysis
CDKN2A was first identified as melanoma predisposition tumour suppressor gene and has been successively studied. The previous researches have not established any noteworthy association with breast cancer. Therefo...
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Article
Open AccessThe evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice
There are more than 2300 genes that are predominantly expressed in mouse testes. The role of hundreds of these genes has been studied in mouse spermatogenesis but still there are many genes whose function is u...
