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Article
Open AccessAF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis
Neuroblastoma is the most common extracranial malignant tumor of childhood, accounting for 15% of all pediatric cancer deaths. Despite significant advances in our understanding of neuroblastoma biology, five-y...
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Correction to: Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway
The authors would like to note an omission of disclosure in this paper. Author JDS is cofounder, equity-holder, and consultant of GILTRx Therapeutics.
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Open AccessIdentification of cell context-dependent YAP-associated proteins reveals β1 and β4 integrin mediate YAP translocation independently of cell spreading
Yes-associated protein (YAP) is a transcriptional regulator and mechanotransducer, relaying extracellular matrix (ECM) stiffness into proliferative gene expression in 2D culture. Previous studies show that YAP...
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Open AccessYAP-independent mechanotransduction drives breast cancer progression
Increased tissue stiffness is a driver of breast cancer progression. The transcriptional regulator YAP is considered a universal mechanotransducer, based largely on 2D culture studies. However, the role of YAP...
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Article
Open AccessMatrix mechanical plasticity regulates cancer cell migration through confining microenvironments
Studies of cancer cell migration have found two modes: one that is protease-independent, requiring micron-sized pores or channels for cells to squeeze through, and one that is protease-dependent, relevant for ...
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Article
Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway
Neuroblastoma is a childhood malignancy that accounts for approximately 15% of childhood cancer deaths. Only 20–35% of children with metastatic neuroblastoma survive with standard therapy. Identification of mo...
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Article
Massively parallel X-ray holography
Advances in the development of free-electron lasers offer the realistic prospect of nanoscale imaging on the timescale of atomic motions. We identify X-ray Fourier-transform holography1,2,3 as a promising but, so...
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Article
PKCα Mediates Maternal Touch Regulation of Growth-Related Gene Expression in Infant Rats
During short-term periods of separation of rat pups from their mothers, the loss of certain sensory signals suppresses the increase in ornithine decarboxylase (ODC) gene expression induced by the growth-promot...
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Ceramide, Aging and Cellular Senescence
Cellular senescence is defined as the finite life span of mammalian cells in culture and has been investigated for the last thirty years. Research employing mammalian cells as well as cells from lower organism...
