Immunotherapy of Cancer
An Innovative Treatment Comes of Age
Page
%P
21 Result(s)
within
Yoshiyuki Yamaguchi
-
Article
Open AccessClinical and epigenetic features of colorectal cancer patients with somatic POLE proofreading mutations
Mutations in the POLE gene result in an ultra-hypermutated phenotype in colorectal cancer (CRC); however, the molecular characterisation of epigenetic alterations remains unclear. We examined the genetic and epig...
-
Article
Open AccessNrf2 gene mutation and single nucleotide polymorphism rs6721961 of the Nrf2 promoter region in renal cell cancer
Nuclear factor erythroid 2–related factor 2 (Nrf2) is involved in cell proliferation by promotion of metabolic activity. It is also the major regulator of antioxidants and has a pivotal role in tumor cell prol...
-
Article
Open AccessThe relationship between peripheral neuropathy and efficacy in second-line chemotherapy for unresectable advanced gastric cancer: a prospective observational multicenter study protocol (IVY)
Paclitaxel is used in second-line conventional chemotherapies to manage patients with unresectable advanced gastric cancer (GC). Paclitaxel-induced peripheral neuropathy is a known adverse event leading to tre...
-
Article
Significance of sarcopenia as a prognostic factor for metastatic urothelial carcinoma patients treated with systemic chemotherapy
Recently, numerous studies have reported an association between sarcopenia and poor outcomes in various kinds of malignancies. We investigated whether sarcopenia predicts the survival of patients with metastat...
-
Article
Open AccessEvaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device
Migration of cancer cell correlates with distant metastasis and local invasion, which are good targets for cancer treatment. An optically accessible device “TAXIScan” was developed, which provides considerably...
-
Book
-
Chapter and Conference Paper
Externally Pressurized Gas Journal Bearings with Asymmetric Gas Supply (Verification of Availability of Gas Pressure Control Using a Small Size Test Rig)
Externally pressurized gas journal bearings with an asymmetric gas supply mechanism have been developed by authors. This bearing has a large load capacity compared with conventional symmetric gas supply bearin...
-
Article
Open AccessThe Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells
Activation of Rho, one of the small GTPases, and its major downstream target Rho-kinase (ROCK) promotes the development and metastasis of cancer. We previously showed that elevation of Rho and ROCK expression ...
-
Article
Open AccessSafety analysis of two different regimens of uracil–tegafur plus leucovorin as adjuvant chemotherapy for high-risk stage II and III colon cancer in a phase III trial comparing 6 with 18 months of treatment: JFMC33-0502 trial
The JFMC33-0502 trial is a phase III clinical study designed to determine the most appropriate duration of postoperative adjuvant chemotherapy with uracil–tegafur (UFT) plus leucovorin in patients with stage ...
-
Article
Regulating surgical oncotaxis to improve the outcomes in cancer patients
Excessive surgical stress and postoperative complications cause a storm of perioperative cytokine release, which has been shown to enhance tumor metastasis in experimental models. We have named this phenomenon...
-
Article
Open AccessIncreased expression of system large amino acid transporter (LAT)-1 mRNA is associated with invasive potential and unfavorable prognosis of human clear cell renal cell carcinoma
The system L amino acid transporter (LAT) has an important role in the transport of various amino acids, and there have been reports about the relation of this system to cancer. Although LATs are highly expres...
-
Chapter
Adoptive Immunotherapy of Cancer Using Autologous Lymphocytes
Adoptive immunotherapy (AIT) of cancer using lymphocytes is a highly promising modality for eradicating cancer. The AIT strategy is less dependently of cancer-associated immune dysfunction, which exists in tum...
-
Article
Open AccessPossible involvement of regulatory T cells in tumor onset and progression in primary breast cancer
The FOXP3 mRNA expression and the other regulatory T cell-related molecules were investigated and compared with clinicopathological parameters in human primary breast cancer.
-
Article
Functional inactivation of CD4+CD25high regulatory T cells using low dose human/mouse chimeric anti-CD25 monoclonal antibody enhanced lymphokine-activated killer cells activity
Functional modulation of regulatory T cells (T-regs) is one possible approach to cancer immunotherapy. In this study, we investigated whether low-dose basiliximab, a chimeric anti-CD25 monoclonal antibody, cou...
-
Article
A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer
Matrix metalloproteinase-9 (MMP-9, gelatinase B) plays a key role in cancer invasion and metastasis by degradating the extracellular matrix (ECM) and basement membrane barriers. A cytosine (C)-thymidine (T) s...
-
Article
A single nucleotide polymorphism in the MMP-1 promoter is correlated with histological differentiation of gastric cancer
Matrix metalloproteinase-1 (MMP-1) plays a key role in cancer invasion and metastasis by degradation of extracellular matrix (ECM) and basement membrane barriers. The 1G/2G single nucleotide polymorphism (SNP)...
-
Article
Adoptive immunotherapy of cancer using activated Autologous lymphocytes-current status and new strategies-
After the discovery of interleukin-2 (IL-2), lymphokine-activated killer (LAK) cells, tumor-infiltrating lymphocytes (TILs), and cytotoxic T lymphocytes (CTLs) sensitized with the mixed lymphocyte-tumor cultur...
-
Article
The role of lymphocyte surface binding sites for wheat germ agglutinin in the negative regulation of cancer patients
The role of lymphocyte surface binding sites for wheat germ agglutinin (WGA) in the negative regulation of cancer patients was investigated. The number of WGA binding sites on the surface of each lymphocyte ra...
-
Article
The expression and biological activity of IL-2 receptor on a human pancreas cancer cell line
To ascertain whether the tumor cells can regulate the host immune systems through the production of the cytokines or their receptors, we examined the expressions of tumor necrosis factorα (TNFα), tumor necrosis f...
-
Article
Effects of the oral or intratumoral administration of OK432 on the immuno-reactivities of regional lymph nodes in gastric cancer patients
The effects of OK432, a streptococcal preparation, administered either orally (PO-OK432) or intratumorally (IT-OK432) on the immuno-reactivities of regional lymph nodes were investigated in gastric cancer pati...
