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Article
Open AccessCorrection to: Tumor budding and fibrotic focus—proposed grading system for tumor budding in invasive carcinoma no special type of the breast
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Chapter and Conference Paper
Development of an Advanced Landslide Simulation Using Clustering Technology
Vegetation has been used as an ecological measure to mitigate landslides. Some computational studies have focused on soil enforcement by plant roots. Generally, root system architecture is important on the rel...
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Article
Open AccessTreatment with trastuzumab deruxtecan in patients with HER2-positive breast cancer and brain metastases and/or leptomeningeal disease (ROSET-BM)
Therapeutic options for breast cancer patients with brain metastases (BM)/leptomeningeal carcinomatosis (LMC) are limited. Here, we report on the effectiveness and safety of trastuzumab deruxtecan (T-DXd) in h...
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Article
Cellulase production on easy-to-handle solid media containing agricultural waste and its application for enzymatic hydrolysis of cellulosic biomass
The process of bioethanol production has several economic drawbacks such as the cost of enzymes, i.e., cellulase, which hydrolyze cellulose to produce fermentable sugars. In this study, to reduce the productio...
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Article
Open AccessTumor budding and fibrotic focus—proposed grading system for tumor budding in invasive carcinoma no special type of the breast
Tumor budding grade is a very useful histological prognostic indicator for colorectal cancer patients. Recently, it has been also reported as a significant prognostic indicator in invasive breast carcinoma pat...
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Chapter and Conference Paper
Computational Study on Dynamic Stall and Flow Control in a Pitching Airfoil
Dynamic stall phenomenon on a Boeing Vetrol-VR-7 airfoil, oscillating at quarter chord with reduced frequency of 0.1, is investigated at three different slot configurations—leading edge, trailing edge and comb...
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Article
Open AccessNeoadjuvant chemotherapy with trastuzumab, docetaxel, and carboplatin administered every 3 weeks for Japanese women with HER2-positive primary breast cancer: efficacy and safety
This phase II neoadjuvant study evaluated the efficacy and safety of a triweekly regimen of docetaxel and carboplatin in combination with trastuzumab (TCbH) in Japanese women with human epidermal growth factor...
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Article
Open AccessGenome-wide identification of thyroid hormone receptor targets in the remodeling intestine during Xenopus tropicalis metamorphosis
Thyroid hormone (T3) affects development and metabolism in vertebrates. We have been studying intestinal remodeling during T3-dependent Xenopus metamorphosis as a model for organ maturation and formation of adult...
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Article
Open AccessOptical imaging of tumor vascularity associated with proliferation and glucose metabolism in early breast cancer: clinical application of total hemoglobin measurements in the breast
Near-infrared optical imaging targeting the intrinsic contrast of tissue hemoglobin has emerged as a promising approach for visualization of vascularity in cancer research. We evaluated the usefulness of diffu...
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Article
Open AccessThyroid hormone receptor actions on transcription in amphibia: The roles of histone modification and chromatin disruption
Thyroid hormone (T3) plays diverse roles in adult organ function and during vertebrate development. The most important stage of mammalian development affected by T3 is the perinatal period when plasma T3 level...
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Article
Open AccessHistone H3K79 methyltransferase Dot1L is directly activated by thyroid hormone receptor during Xenopus metamorphosis
Thyroid hormone (T3) is important for adult organ function and vertebrate development. Amphibian metamorphosis is totally dependent on T3 and offers a unique opportunity to study how T3 controls postembryonic ...
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Article
A false positive for metastatic lymph nodes in the axillary region of a breast cancer patient following mastectomy
Recent advanced imaging modalities such as positron emission tomography (PET) detect malignancies using 2-[18F]-fluoro-2-deoxy-d-glucose (18-FDG) with high accuracy, and they contribute to decisions regarding dia...
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Article
BiClamp forceps significantly shorten the operation time for breast surgery
A novel approach was introduced for breast surgery using the BiClamp, a new bipolar thermal energy device, to avoid complications and to shorten the time required for the dissection of the axillary lymph nodes.
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Article
Open AccessPossible involvement of regulatory T cells in tumor onset and progression in primary breast cancer
The FOXP3 mRNA expression and the other regulatory T cell-related molecules were investigated and compared with clinicopathological parameters in human primary breast cancer.
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Article
Successful treatment of leptomeningeal metastases from breast cancer using the combination of trastuzumab and capecitabine: a case report
We report a case of metastatic breast cancer with leptomeninges and multiple bone metastases that showed an excellent response to the combination of trastuzumab and capecitabine; therapeutic effect was evaluat...
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Article
Functional inactivation of CD4+CD25high regulatory T cells using low dose human/mouse chimeric anti-CD25 monoclonal antibody enhanced lymphokine-activated killer cells activity
Functional modulation of regulatory T cells (T-regs) is one possible approach to cancer immunotherapy. In this study, we investigated whether low-dose basiliximab, a chimeric anti-CD25 monoclonal antibody, cou...
