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  1. Article

    Open Access

    Mechanical activities of self-beating cardiomyocyte aggregates under mechanical compression

    Since the discovery of synchronous pulsations in cardiomyocytes (CMs), electrical communication between CMs has been emphasized; however, recent studies suggest the possibility of mechanical communication. Her...

    Ken Nakano, Naoya Nanri, Yoshinari Tsukamoto, Mitsuru Akashi in Scientific Reports (2021)

  2. Article

    Open Access

    Vascularized cardiac tissue construction with orientation by layer-by-layer method and 3D printer

    Herein, we report the fabrication of native organ-like three-dimensional (3D) cardiac tissue with an oriented structure and vascular network using a layer-by-layer (LbL), cell accumulation and 3D printing tech...

    Yoshinari Tsukamoto, Takami Akagi, Mitsuru Akashi in Scientific Reports (2020)

  3. Article

    Open Access

    Engraftment and morphological development of vascularized human iPS cell-derived 3D-cardiomyocyte tissue after xenotransplantation

    One of the major challenges in cell-based cardiac regenerative medicine is the in vitro construction of three-dimensional (3D) tissues consisting of induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) a...

    Hirokazu Narita, Fumiaki Shima, Junya Yokoyama, Shigeru Miyagawa in Scientific Reports (2017)