58 Result(s)

Article

TNIP3 protects against pathological cardiac hypertrophy by stabilizing STAT1

Pathological cardiac hypertrophy is one of the major risk factors of heart failure and other cardiovascular diseases. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown....

Hongjie Shi, Yongjie Yu, Dajun Li, Kun Zhu, Xu Cheng, Tengfei Ma… in Cell Death & Disease (2024)

Article

ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway

The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral am...

**ze Li, Yingli Yan, Yang Fu, Zhe Chen… in Cellular & Molecular Biology Letters (2024)

Article

Single-cell multi-omics analysis of lineage development and spatial organization in the human fetal cerebellum

Human cerebellum encompasses numerous neurons, exhibiting a distinct developmental paradigm from cerebrum. Here we conducted scRNA-seq, scATAC-seq and spatial transcriptomic analyses of fetal samples from gest...

Fuqiang Yang, Ziqi Zhao, Dan Zhang, Yu **ong, **nran Dong, Yuchen Wang… in Cell Discovery (2024)

Article

The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging

The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% ...

Zoltan Ungvari, Adam G. Tabák, Roza Adany, György Purebl, Csilla Kaposvári… in GeroScience (2024)

Article

MET fusions are targetable genomic variants in the treatment of advanced malignancies

Targeted therapy for malignancies has developed rapidly in recent years, benefiting patients harboring genetic mutations sensitive to relevant tyrosine kinase inhibitors (TKIs). With the development of targete...

Dantong Sun, **aoming **ng, Yongjie Wang, Helei Hou in Cell Communication and Signaling (2024)

Article

Author Correction: Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing

Ziqi Zhao, Dan Zhang, Fuqiang Yang, Mingrui Xu, Shaoli Zhao, Taotao Pan… in Cell Research (2023)

Article

ATXN3 promotes prostate cancer progression by stabilizing YAP

Prostate cancer (PC) is the most common neoplasm and is the second leading cause of cancer-related deaths in men worldwide. The Hippo tumor suppressor pathway is highly conserved in mammals and plays an import...

Longxiang Wu, Zhenyu Ou, Peihua Liu, Cheng Zhao… in Cell Communication and Signaling (2023)

Article

Brain nuclear receptors and cardiovascular function

Brain–heart interaction has raised up increasing attentions. Nuclear receptors (NRs) are abundantly expressed in the brain, and emerging evidence indicates that a number of these brain NRs regulate multiple as...

Mengjie Wang, Yongjie Yang, Yong Xu in Cell & Bioscience (2023)

Article

SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis

Pro-opiomelanocortin (POMC) neurons play a sexually dimorphic role in body weight and glucose balance. However, the mechanisms for the sex differences in POMC neuron functions are not fully understood.

Meng Yu, Jonathan C. Bean, Hailan Liu, Yang He, Yongjie Yang, **ng Cai… in Cell & Bioscience (2022)

Article

Single-cell dissection of remodeled inflammatory ecosystem in primary and metastatic gallbladder carcinoma

Gallbladder carcinoma (GBC) is the most common biliary tract malignancy with the lowest survival rate, primarily arising from chronic inflammation. To better characterize the progression from inflammation to c...

**ang Wang, Chunliang Liu, Jianan Chen, Lei Chen, **anwen Ren… in Cell Discovery (2022)

Article

The alternative splicing of intersectin 1 regulated by PTBP1 promotes human glioma progression

Intersectin 1 (ITSN1) contains two isoforms: ITSN1-S and ITSN1-L, which are highly regulated by alternative splicing. Our previous results showed that the two isoforms of ITSN1 displayed opposite functions: IT...

Chungen Lan, Huikun Zhang, Kezhen Wang, **aoli Liu, Yawen Zhao… in Cell Death & Disease (2022)

Article

Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing

The differences in size and function between primate and rodent brains, and the association of disturbed excitatory/inhibitory balance with many neurodevelopmental disorders highlight the importance to study p...

Ziqi Zhao, Dan Zhang, Fuqiang Yang, Mingrui Xu, Shaoli Zhao, Taotao Pan… in Cell Research (2022)

Article

NOX activation in reactive astrocytes regulates astrocytic LCN2 expression and neurodegeneration

Reactive astrocytes (RA) secrete lipocalin-2 (LCN2) glycoprotein that regulates diverse cellular processes including cell death/survival, inflammation, iron delivery and cell differentiation. Elevated levels o...

Ruijia Liu, Jun Wang, Yang Chen, Jenelle M. Collier, Okan Capuk… in Cell Death & Disease (2022)

Article

METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism

N6-methyladenine (m6A) is the most predominant RNA modification, which has been shown to be related to many types of cancers. However, understanding of its role in prostate cancer (PCa) is largely unknown. Her...

Yongjie Wang, Junfei Chen, Wei-Qiang Gao, Ru Yang in Cell Death Discovery (2022)

Article

Rcl1 suppresses tumor progression of hepatocellular carcinoma: a comprehensive analysis of bioinformatics and in vitro experiments

RNA 3’-terminal phosphate cyclase-like protein (Rcl1) is involved in pre-rRNA processing, but its implication in cancers remains unclear.

Yu Jiaze, Hou Sinan, Yang Minjie, Zhou Yongjie, Du Nan… in Cancer Cell International (2022)