-
Article
Open AccessA streamlined approach for intelligent ship object detection using EL-YOLO algorithm
Maritime objects frequently exhibit low-quality and insufficient feature information, particularly in complex maritime environments characterized by challenges such as small objects, waves, and reflections. Th...
-
Article
COVID-19 in patients with myasthenia gravis: a single-center retrospective study in China
Coronavirus disease 2019 (COVID-19) has been a great concern since 2019. Patients with myasthenia gravis (MG) may be at higher risk of COVID-19 and a more severe disease course. We examined the associations be...
-
Article
Open AccessImprovement of plant resistance to geminiviruses via protein de-S-acylation
Geminiviruses are an important group of viruses that infect a variety of plants and result in heavy agricultural losses worldwide. The homologs of C4 (or L4) in monopartite geminiviruses and AC4 (or AL4) in bi...
-
Article
Porous Structures of C-Shaped Polypropylene Fibers and Oil-Absorbing Performance of Their Spun-Bond Non-woven Fabrics
Spun-bond non-woven fabrics (NWFs) made of porous C-shaped polypropylene fibers were applied in rapid oil absorption and effective on-line oil spillage monitoring. It is of great interest to further optimize t...
-
Article
Open AccessClinical and genetic interpretation of uncertain DMD missense variants: evidence from mRNA and protein studies
Pathogenic missense variants in the dystrophin (DMD) gene are rarely reported in dystrophinopathies. Most DMD missense variants are of uncertain significance and their pathogenicity interpretation remains complic...
-
Article
Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake
Ghrelin, produced mainly by gastric X/A-like cells, triggers a hunger signal to the central nervous system to stimulate appetite. It remains unclear whether X/A-like cells sense gastric distention and thus reg...
-
Article
Open AccessWhat should we expect when two myositis-specific antibodies coexist in a patient
The coexistence of two myositis-specific autoantibodies (MSA) is considered extremely rare. We describe three patients with both anti-signal recognition particle (SRP) antibodies and another MSA in serum.
-
Article
Open AccessBrain MRI correlations with disease burden and biomarkers in Fabry disease
To quantitatively evaluate cerebral small vessel disease (CSVD) in brain magnetic resonance imaging (MRI) and its correlation with disease burden and markers in Fabry disease, a rare X-linked lysosomal storage...
-
Article
Comparison between ESD and RFA in patients with total or near-total circumferential early esophageal squamous cell neoplasia
Patients with early esophageal squamous cell neoplasias (ESCNs) that are totally or nearly totally circumferential face challenges in their clinical work. Endoscopic submucosal dissection (ESD) frequently lead...
-
Article
Open AccessWater channel protein AQP1 in cytoplasm is a critical factor in breast cancer local invasion
Metastasis of breast cancer grows from the local invasion to the distant colonization. Blocking the local invasion step would be promising for breast cancer treatment. Our present study demonstrated AQP1 was a...
-
Article
Open AccessThe alternative splicing of intersectin 1 regulated by PTBP1 promotes human glioma progression
Intersectin 1 (ITSN1) contains two isoforms: ITSN1-S and ITSN1-L, which are highly regulated by alternative splicing. Our previous results showed that the two isoforms of ITSN1 displayed opposite functions: IT...
-
Article
Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases
There is increasing evidence for the role of inflammation in the pathogenesis of mitochondrial diseases (MDs). However, the mechanisms underlying mutation-induced inflammation in MD remain elusive. Our previou...
-
Chapter and Conference Paper
A Boosting Algorithm for Training from Only Unlabeled Data
Unlabeled-unlabeled (UU) learning was proposed to cope with the high cost of data annotation and some realistic cases, in which we cannot get labeled data. It allows us to train a classifier with only unlabele...
-
Article
Open AccessEndocytic protein intersectin1-S shuttles into nucleus to suppress the DNA replication in breast cancer
Breast cancer is the most common type of cancer worldwide. However, the well-known molecular biomarkers are not enough to meet the needs of precision medicine. In search for novel targets in this regard, we re...
-
Article
Experimental study of the dynamic response and failure mode of anti-dip rock slopes
The mechanisms and characteristics of earthquake-triggered anti-dip rock landslides remain largely unknown. In this study, the dynamic response characteristics and failure process of anti-dip layered rock slop...
-
Article
A novel defensin-like peptide contributing to antimicrobial and antioxidant capacity of the tick Dermacentor silvarum (Acari: Ixodidae)
Defensins are the most diverse groups of antimicrobial peptides in invertebrate animals. In ticks, defensins show great potential as targets for tick control, and display future prospect for therapeutic drug d...
-
Article
Open AccessAquaporin 1 promotes sensitivity of anthracycline chemotherapy in breast cancer by inhibiting β-catenin degradation to enhance TopoIIα activity
Anthracyclines are a class of conventional and commonly used frontline chemotherapy drugs to treat breast cancer. However, the anthracycline-based regimens can only reduce breast cancer mortality by 20–30%. Fu...
-
Article
Open AccessLate-onset multiple acyl-CoA dehydrogenase deficiency mimicking myositis in an elderly patient: a case report
Late-onset multiple acyl-CoA dehydrogenase deficiency (MADD) is a rare and treatable inherited lipid storage myopathy. Here, we report an elderly patient with MADD mimicking myositis.
-
Article
Open AccessFactors associated with refractory autoimmune necrotizing myopathy with anti-signal recognition particle antibodies
Autoimmune necrotizing myopathy with anti-signal recognition particle antibodies (ANM-SRP) is regarded as refractory myositis, whereby some patients respond poorly to conventional immunosuppression and require...
-
Article
Estimation of soil organic carbon losses and counter approaches from organic materials in black soils of northeastern China
The northeast plain of China is one of three extensive regions with black soil rich in organic matter in the northern hemisphere. The replacement of natural grassland with cropland has resulted in massive loss...
