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  1. Article

    Open Access

    A deep dive into burn-mediated ARDS severity assessment: a retrospective study on hematological markers

    Acute Respiratory Distress Syndrome (ARDS) is a critical form of Acute Lung Injury (ALI), challenging clinical diagnosis and severity assessment. This study evaluates the potential utility of various hematolog...

    Jeongsoo Park, Dohern Kym, Jun Hur, Jaechul Yoon, Myong** Kim in Scientific Reports (2024)

  2. Article

    Open Access

    Big data insights into the diagnostic values of CBC parameters for sepsis and septic shock in burn patients: a retrospective study

    Sepsis and septic shock are prevalent and life-threatening complications in burn patients. Despite their severity, existing diagnostic methods are limited. This study aims to evaluate the efficacy of Complete ...

    Myong** Kim, Dohern Kym, Jongsoo Park, Jaechul Yoon, Yong Suk Cho in Scientific Reports (2024)

  3. Article

    Open Access

    Pioneering predictions of AKI and AKIN severity in burn patients: a comprehensive CBC approach

    This study aims to evaluate the utility of complete blood count (CBC) markers, in conjunction with the acute kidney injury network (AKIN) criteria, for the early detection, severity assessment, and prediction ...

    Jongsoo Park, Dohern Kym, Myong** Kim, Yong Suk Cho, Jun Hur in Scientific Reports (2024)

  4. Article

    Open Access

    Evaluating clinical heterogeneity and predicting mortality in severely burned patients through unsupervised clustering and latent class analysis

    Burn injuries often result in a high level of clinical heterogeneity and poor prognosis in patients with severe burns. Clustering algorithms, which are unsupervised methods that can identify groups with simila...

    Sungmin Kim, Jaechul Yoon, Dohern Kym, Jun Hur, Myong** Kim in Scientific Reports (2023)

  5. Article

    Open Access

    YAP inhibits ERα and ER+ breast cancer growth by disrupting a TEAD-ERα signaling axis

    Hippo signaling restricts tissue growth by inhibiting the transcriptional effector YAP. Here we uncover a role of Hippo signaling and a tumor suppressor function of YAP in estrogen receptor positive (ER+) breast ...

    Xu Li, Shu Zhuo, Ting Zhuang, Yong Suk Cho, Guo** Wu, Yuchen Liu in Nature Communications (2022)

  6. Article

    Open Access

    Trajectories of longitudinal biomarkers for mortality in severely burned patients

    This study aimed to investigate the differences in the trajectory of blood biomarkers routinely assessed through forward- and backward-looking approaches among burn patients. This cohort study included patient...

    Jaechul Yoon, Dohern Kym, Jae Hee Won, Jun Hur, Haejun Yim in Scientific Reports (2020)

  7. Article

    Open Access

    A population-based epidemiology of Wilson’s disease in South Korea between 2010 and 2016

    Very few population-based studies have examined the epidemiology of Wilson’s disease (WD). We investigated the epidemiology of WD using the National Health Insurance Service (NHIS) database in South Korea. We ...

    Eun Ju Choe, Jong Won Choi, Min** Kang, Yong Kang Lee, Han Ho Jeon in Scientific Reports (2020)

  8. Article

    Open Access

    Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K

    Hippo (Hpo) signaling pathway controls tissue growth by regulating the subcellular localization of Yorkie (Yki)/Yap via a cytoplasmic kinase cassette containing an upstream kinase Hpo/MST1/2 and a downstream k...

    Yong suk Cho, Jian Zhu, Shuangxi Li, Bing Wang, Yuhong Han in Nature Communications (2018)