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Open AccessA deep dive into burn-mediated ARDS severity assessment: a retrospective study on hematological markers
Acute Respiratory Distress Syndrome (ARDS) is a critical form of Acute Lung Injury (ALI), challenging clinical diagnosis and severity assessment. This study evaluates the potential utility of various hematolog...
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Article
Open AccessBig data insights into the diagnostic values of CBC parameters for sepsis and septic shock in burn patients: a retrospective study
Sepsis and septic shock are prevalent and life-threatening complications in burn patients. Despite their severity, existing diagnostic methods are limited. This study aims to evaluate the efficacy of Complete ...
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Article
Open AccessPioneering predictions of AKI and AKIN severity in burn patients: a comprehensive CBC approach
This study aims to evaluate the utility of complete blood count (CBC) markers, in conjunction with the acute kidney injury network (AKIN) criteria, for the early detection, severity assessment, and prediction ...
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Article
Open AccessEvaluating clinical heterogeneity and predicting mortality in severely burned patients through unsupervised clustering and latent class analysis
Burn injuries often result in a high level of clinical heterogeneity and poor prognosis in patients with severe burns. Clustering algorithms, which are unsupervised methods that can identify groups with simila...
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Article
Open AccessYAP inhibits ERα and ER+ breast cancer growth by disrupting a TEAD-ERα signaling axis
Hippo signaling restricts tissue growth by inhibiting the transcriptional effector YAP. Here we uncover a role of Hippo signaling and a tumor suppressor function of YAP in estrogen receptor positive (ER+) breast ...
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Article
Open AccessTrajectories of longitudinal biomarkers for mortality in severely burned patients
This study aimed to investigate the differences in the trajectory of blood biomarkers routinely assessed through forward- and backward-looking approaches among burn patients. This cohort study included patient...
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Article
Open AccessA population-based epidemiology of Wilson’s disease in South Korea between 2010 and 2016
Very few population-based studies have examined the epidemiology of Wilson’s disease (WD). We investigated the epidemiology of WD using the National Health Insurance Service (NHIS) database in South Korea. We ...
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Article
Open AccessRegulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K
Hippo (Hpo) signaling pathway controls tissue growth by regulating the subcellular localization of Yorkie (Yki)/Yap via a cytoplasmic kinase cassette containing an upstream kinase Hpo/MST1/2 and a downstream k...