159 Result(s)

Article

Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer’s Disease

Neuroinflammation and endothelial cell apoptosis are prominent features of blood–brain barrier (BBB) disruption, which have been described in Alzheimer’s disease (AD) and can predict cognitive decline. Recent ...

**ao-Fang Wang, **ao-Hong **ang, **g Wei, Peng-Bo Zhang, Qin Xu… in Neurochemical Research (2024)

Article

Functional role of P2X7 purinergic receptor in cancer and cancer-related pain

Numerous studies have revealed that the ATP-gated ion channel purinergic 2X7 receptor (P2X7R) plays an important role in tumor progression and the pathogenesis of cancer pain. P2X7R requires activation by extr...

Yong-sheng Xu, Jun **ang, Si-jian Lin in Purinergic Signalling (2024)

Article

Rosmarinic acid ameliorated oxidative stress, neuronal injuries, and mitochondrial dysfunctions mediated by polyglutamine and ɑ-synuclein in Caenorhabditis elegans models

Numerous natural antioxidants have been developed into agents for neurodegenerative diseases (NDs) treatment. Rosmarinic acid (RA), an excellent antioxidant, exhibits neuroprotective activity, but its anti-NDs...

Yun Chen, Ruina Xu, Qiaoxing Liu, Yanting Zeng, Weitian Chen… in Molecular Neurobiology (2024)

Article

Loss of CHCHD2 Stability Coordinates with C1QBP/CHCHD2/CHCHD10 Complex Impairment to Mediate PD-Linked Mitochondrial Dysfunction

Novel CHCHD2 mutations causing C-terminal truncation and interrupted CHCHD2 protein stability in Parkinson's disease (PD) patients were previously found. However, there is limited understanding of the underlying ...

Yan-Lin Ren, Zheng Jiang, Jia-Yi Wang, Qin He, Si-Xu Li… in Molecular Neurobiology (2024)

Article

Neuroticism and openness exhibit an anti-correlation pattern to dissociable default mode network: using resting connectivity and structural equation modeling analysis

The default mode network (DMN) can be subdivided into ventral and dorsal subsystems, which serve affective cognition and mental sense construction, respectively. An internally dissociated pattern of anti-corre...

Shengwen Zhi, Wentao Zhao, Yifei Huang, Yue Li, **ao Wang… in Brain Imaging and Behavior (2024)

Article

An ACC–VTA–ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences

The central mechanisms underlying pain chronicity remain elusive. Here, we identify a reciprocal neuronal circuit in mice between the anterior cingulate cortex (ACC) and the ventral tegmental area (VTA) that m...

Qian Song, Anqi Wei, Huadong Xu, Yuhao Gu, Yong Jiang, Nan Dong… in Nature Neuroscience (2024)

Article

Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial

Perioperative chemotherapy is the standard treatment for locally advanced gastric or gastro-esophageal junction cancer, and the addition of programmed cell death 1 (PD-1) inhibitor is under investigation. In t...

Shu-Qiang Yuan, Run-Cong Nie, Ying **, Cheng-Cai Liang, Yuan-Fang Li… in Nature Medicine (2024)

Article

PDGFβ receptor-targeted delivery of truncated transforming growth factor β receptor type II for improving the in vitro and in vivo anti-renal fibrosis activity via strong inactivation of TGF-β1/Smad signaling pathway

Truncated transforming growth factor β receptor type II (tTβRII), serving as a trap for binding excessive transforming growth factor β1 (TGF-β1) by means of competing with wild-type TβRII, is a promising stra...

Bing Wang, **aohua Wang, Yixin Dong… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2024)

Article

Enterochromaffin Cell: Friend or Foe for Human Health?

Yang Yu, Yong-Chang Li, Fu-Chao Zhang, Guang-Yin Xu in Neuroscience Bulletin (2023)

Article

Imbalance of multiple neurotransmitter pathways leading to depression-like behavior and cognitive dysfunction in the triple transgenic mouse model of Alzheimer disease

Depression is among the most frequent psychiatric comorbid conditions in Alzheimer disease (AD). However, pharmacotherapy for depressive disorders in AD is still a big challenge, and the data on the efffcacy o...

Meng Zhang, Li-yuan Liu, Yong Xu, Wen-zhi Wang, Nian-zhuang Qiu… in Metabolic Brain Disease (2023)

Article

The Aging Biomarker Consortium represents a new era for aging research in China

Jie Ren, Moshi Song, Weiqi Zhang, Jian-** Cai, Feng Cao, Zhongwei Cao… in Nature Medicine (2023)

Article

Activity-Dependent Phosphorylation of CDKL5 at Serine 407 Regulates Synaptogenesis and Plasticity

Mengying Jiang, Qiwu Xu, Can Yang, Dan Li, Ji-Wei Liu… in Neuroscience Bulletin (2023)

Article

Correlation Analysis of Molecularly-Defined Cortical Interneuron Populations with Morpho-Electric Properties in Layer V of Mouse Neocortex

Cortical interneurons can be categorized into distinct populations based on multiple modalities, including molecular signatures and morpho-electrical (M/E) properties. Recently, many transcriptomic signatures ...

Jun-Wei Cao, **ao-Yi Mao, Liang Zhu, Zhi-Shuo Zhou, Shao-Na Jiang… in Neuroscience Bulletin (2023)

Article

Resveratrol and Sir2 Reverse Sleep and Memory Defects Induced by Amyloid Precursor Protein

Resveratrol (RES), a natural polyphenolic phytochemical, has been suggested as a putative anti-aging molecule for the prevention and treatment of Alzheimer’s disease (AD) by the activation of sirtuin 1 (Sirt1/...

Yu** Hao, Lingzhan Shao, Jianan Hou, Yan Zhang, Yuqian Ma… in Neuroscience Bulletin (2023)