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Article
Activity-Dependent Phosphorylation of CDKL5 at Serine 407 Regulates Synaptogenesis and Plasticity
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Article
Open AccessThe effect of intensive family-centered health education on the awareness rate, diagnosis, and treatment of post-stroke depression in community families
To investigate the effects of intensive family-centered health education on the awareness rate, diagnosis, and treatment of post-stroke depression (PSD) in community families.
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Article
Open AccessResequencing 545 ginkgo genomes across the world reveals the evolutionary history of the living fossil
As Charles Darwin anticipated, living fossils provide excellent opportunities to study evolutionary questions related to extinction, competition, and adaptation. Ginkgo (Ginkgo biloba L.) is one of the oldest liv...
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Article
Chromosome level comparative analysis of Brassica genomes
We provided a chromosome-length assembly of B. nigra and show the comprehensive chromosome-scale variations among Brassica genomes.
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Article
Open AccessGenome-wide Target Enrichment-aided Chip Design: a 66 K SNP Chip for Cashmere Goat
Compared with the commercially available single nucleotide polymorphism (SNP) chip based on the Bead Chip technology, the solution hybrid selection (SHS)-based target enrichment SNP chip is not only design-fle...
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Article
Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering
Excess ammonia in the blood can cause neurologic dysfunction and seizures. Although previous studies have suggested astrocyte swelling and brain edema are associated with hyperammonemia, the authors show that ...
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Article
Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture
Acupuncture can locally reduce pain, but it has remained unclear how it might work. Goldman et al. find that acupuncture elevates local tissue adenosine levels in a mouse model. The anti-nociceptive effect of acu...
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Article
Adenosine is crucial for deep brain stimulation–mediated attenuation of tremor
Deep brain stimulation (DBS) is a widely used neurosurgical approach to treating tremor and other movement disorders1,2,3. In addition, the use of DBS in a number of psychiatric diseases, including obsessive-comp...
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Article
Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
Although astrocytes are the most abundant cell type in the brain, evidence for their activation during physiological sensory activity is lacking. Here we show that whisker stimulation evokes increases in astro...
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Article
An astrocytic basis of epilepsy
Hypersynchronous neuronal firing is a hallmark of epilepsy, but the mechanisms underlying simultaneous activation of multiple neurons remains unknown. Epileptic discharges are in part initiated by a local depo...
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Article
P2X7 receptor inhibition improves recovery after spinal cord injury
Secondary injury exacerbates the extent of spinal cord insults, yet the mechanistic basis of this phenomenon has largely been unexplored. Here we report that broad regions of the peritraumatic zone are charact...
