477 Result(s)
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Article
Cross-species genomics matches driver mutations and cell compartments to model ependymoma
Ependymoma is a type of neural tumour that arises throughout the central nervous system. Using comparative transcriptomics in mouse and human tumours, Johnson et al. home in on mutations that are specific to indi...
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Open AccessApproaching the ideal elastic limit of metallic glasses
The ideal elastic limit is the upper bound to the stress and elastic strain a material can withstand. This intrinsic property has been widely studied for crystalline metals, both theoretically and experimental...
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Quantum teleportation and entanglement distribution over 100-kilometre free-space channels
Quantum teleportation of independent qubits and entanglement distribution have been demonstrated over free-space channels of about 100 kilometres, representing an important step towards a global quantum network.
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Open AccessSensitive Real-Time Monitoring of Refractive Indexes Using a Novel Graphene-Based Optical Sensor
Based on the polarization-sensitive absorption of graphene under conditions of total internal reflection, a novel optical sensor combining graphene and a microfluidic structure was constructed to achieve the s...
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Open AccessInterferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals
The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C...
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Open AccessGenome of the Chinese tree shrew
Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as model...
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Article
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
Algorithms designed to identify canonical yeast prions predict that around 250 human proteins, including several RNA-binding proteins associated with neurodegenerative disease, harbour a distinctive prion-like...
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Open AccessSelf-assembled foam-like graphene networks formed through nucleate boiling
Self-assembled foam-like graphene (SFG) structures were formed using a simple nucleate boiling method, which is governed by the dynamics of bubble generation and departure in the graphene colloid solution. The...
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Open AccessIdentification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that varian...
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Open AccessDraft genome of the wheat A-genome progenitor Triticum urartu
The genome sequence and its analysis of the diploid wild wheat Triticum urartu (progenitor of the wheat A genome) represent a tool for studying the complex, polyploid wheat genomes and should be a valuable resour...
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Open AccessAegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation
Sequencing and analysing the diploid genome and transcriptome of Aegilops tauschii provide new insights into the role of this genome in enabling the adaptation of bread wheat and are a step towards understanding ...
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Open AccessALKBH4-dependent demethylation of actin regulates actomyosin dynamics
Regulation of actomyosin dynamics by post-transcriptional modifications in cytoplasmic actin is still poorly understood. Here we demonstrate that dioxygenase ALKBH4-mediated demethylation of a monomethylated s...
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Open AccessDraft genome sequence of the mulberry tree Morus notabilis
Human utilization of the mulberry–silkworm interaction started at least 5,000 years ago and greatly influenced world history through the Silk Road. Complementing the silkworm genome sequence, here we describe ...
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Open AccessIsotopic evidence for continental ice sheet in mid-latitude region in the supergreenhouse Early Cretaceous
Cretaceous represents one of the hottest greenhouse periods in the Earth's history, but some recent studies suggest that small ice caps might be present in non-polar regions during certain periods in the Early...
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Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase
SAMHD1 is a dGTP-activated deoxynucleoside triphosphate triphosphohydrolase (dNTPase) whose dNTPase activity has been linked to HIV/SIV restriction. The mechanism of its dGTP-activated dNTPase function remains...
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Open AccessThe natural compound magnolol inhibits invasion and exhibits potential in human breast cancer therapy
Invasion and metastasis are the main causes of treatment failure and death in breast cancer. Thus, novel invasion-based therapies such as those involving natural agents are urgently required. In this study, we...
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Open AccessDewetting Properties of Metallic Liquid Film on Nanopillared Graphene
In this work, we report simulation evidence that the graphene surface decorated by carbon nanotube pillars shows strong dewettability, which can give it great advantages in dewetting and detaching metallic nan...
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Open AccessThe DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth
Adenylate kinase 2 (AK2), which balances adenine nucleotide pool, is a multi-functional protein. Here we show that AK2 negatively regulates tumour cell growth. AK2 forms a complex with dual-specificity phospha...
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Article
Helicobacter pylori CagA promotes Snail-mediated epithelial–mesenchymal transition by reducing GSK-3 activity
Cytotoxin-associated gene A (CagA) is an oncoprotein and a major virulence factor of H. pylori. CagA is delivered into gastric epithelial cells via a type IV secretion system and causes cellular transformation. T...
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Open AccessThe complex jujube genome provides insights into fruit tree biology
The jujube (Ziziphus jujuba Mill.), a member of family Rhamnaceae, is a major dry fruit and a traditional herbal medicine for more than one billion people. Here we present a high-quality sequence for the complex ...
